Complement activation, classical pathway (Bos taurus)
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Ions
Proteolytic Cleavage
Cytoplasm
C1 complex
antigen/antibody
complex
Plasma
Membrane
Complex
Formation
Prevents Complement Attack
aggregated IgG,
IgM-antigen complex,
polyanions, RNA, DNA
lipopolysaccharides
Membrane
attack complex
C1QB
MASP1
C1R
C1QA
C3
C4B
C7
C5
C9
H2O
C1QC
C1S
C6
C8A
C2
C4A
CD55
C8B
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP545(r21826)
with a 82% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN; ''Opportunities for new therapies based on the natural regulators of complement activation.''; Ann N Y Acad Sci, 2005
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
117490
view
11:01, 21 May 2021
Eweitz
Modified title
105970
view
11:50, 16 August 2019
MaintBot
HMDB identifier normalization
89917
view
13:31, 6 October 2016
Mkutmon
Ontology Term : 'immune response pathway' added !
89916
view
13:31, 6 October 2016
Mkutmon
Ontology Term : 'classical complement pathway' added !
89915
view
13:31, 6 October 2016
Mkutmon
Ontology Term : 'innate immune response pathway' added !
89914
view
13:30, 6 October 2016
Mkutmon
Modified description
80673
view
15:21, 30 June 2015
Mkutmon
homology conversion
63463
view
17:19, 10 May 2013
MaintBot
Updated to 2013 gpml schema
40598
view
19:34, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33835
view
00:30, 9 December 2009
MaintBot
Automatic update of empty xrefs
33622
view
10:02, 1 December 2009
MaintBot
Removed group label
31636
view
22:24, 13 August 2009
MaintBot
Fixed text labels
30546
view
21:58, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
C1QA
GeneProduct
534961 (Entrez Gene)
update: C1QA HUMAN
C1QB
GeneProduct
617435 (Entrez Gene)
C1QC
GeneProduct
509968 (Entrez Gene)
update C1QC HUMAN
C1R
GeneProduct
511581 (Entrez Gene)
C1S
GeneProduct
767827 (Entrez Gene)
C2
GeneProduct
515440 (Entrez Gene)
C3
GeneProduct
280677 (Entrez Gene)
C4A
GeneProduct
280678 (Entrez Gene)
C4B
GeneProduct
C5
GeneProduct
512045 (Entrez Gene)
C6
GeneProduct
507749 (Entrez Gene)
C7
GeneProduct
507339 (Entrez Gene)
C8A
GeneProduct
527391 (Entrez Gene)
C8B
GeneProduct
513217 (Entrez Gene)
C9
GeneProduct
526766 (Entrez Gene)
CD55
GeneProduct
518609 (Entrez Gene)
H2O
Metabolite
HMDB02111 (HMDB)
MASP1
GeneProduct
522347 (Entrez Gene)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions