Methylation (Gallus gallus)
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SAM synthesis (co-substrate)
S-methylation
O-methylation
N-methylation
MAT1A
S-Adenosylhomocysteine
S-Adenosylhomocysteine
S-Adenosylmethionine
MAT2B
INMT
S-methylated substrate
MAT2A
ATP
Phosphate
S-Adenosylhomocysteine
O-methylated substrate
TPMT
PNMT
Substrate
N-methylated substrate
S-Adenosylmethionine
Phosphate
S-Adenosylmethionine
COMT
NNMT
L-Methionine
HNMT
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP704(r30265)
with a 55% conversion rate.
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Bibliography
Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008
PubMed
Europe PMC
Scholia
Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
118251
view
12:04, 26 May 2021
Eweitz
Modified title
106110
view
12:01, 16 August 2019
MaintBot
HMDB identifier normalization
68791
view
17:13, 8 July 2013
MaintBot
Updated to 2013 gpml schema
58768
view
22:15, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
40922
view
22:51, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33853
view
17:43, 9 December 2009
MaintBot
Automatic update of empty xrefs
33448
view
14:59, 30 November 2009
MaintBot
Removed group label
30334
view
20:47, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATP
Metabolite
HMDB00538 (HMDB)
COMT
GeneProduct
ENSGALG00000002024 (Ensembl Chicken)
HNMT
GeneProduct
ENSGALG00000012377 (Ensembl Chicken)
INMT
GeneProduct
L-Methionine
Metabolite
HMDB00696 (HMDB)
MAT1A
GeneProduct
ENSGALG00000002479 (Ensembl Chicken)
MAT2A
GeneProduct
MAT2B
GeneProduct
ENSGALG00000001750 (Ensembl Chicken)
N-methylated substrate
Metabolite
NNMT
GeneProduct
O-methylated substrate
Metabolite
PNMT
GeneProduct
776803 (Entrez Gene)
Phosphate
Metabolite
HMDB01429 (HMDB)
S-Adenosylhomocysteine
Metabolite
HMDB00939 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB01185 (HMDB)
S-methylated substrate
Metabolite
Substrate
Metabolite
TPMT
GeneProduct
ENSGALG00000012687 (Ensembl Chicken)
Annotated Interactions
No annotated interactions
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