G1 to S cell cycle control (Gallus gallus)
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e
u
G2 Phase-M phase
p
origin recognition complex
Checkpoint
e
Rb
DNA replication
p
inactive
G1/S transition Phase
phosphorylation of proteins
involved in G1/S transition
p
u
G1 Cyclin
Dependant Cyclases
p
p
DNA polymerases
G1/S Cell Cycle
u
E2f
b
cak
Cyclin Es
G1/S transition Cyclin
Dependent Kinases
TTTCC/GCGC
G1 Phase
b
Cell cycle DNA replication genes
dp1
p
Degradation
Cyclin Ds
MYT1
CyclinD
CCND3
CDKN1C
MYC
CCND2
MCM5
E2f
CCNA1
ORC3L
MCM7
RB1
E2F4
CyclinD
ORC2L
CDC25A
PRIM1
CREB3L4
CDKN2C
TPTE
ORC6L
POLE
WEE1
TP53
CDKN1B
E2F3
MCM2
CCNG2
TFDP1
ATM
MCM4
PCNA
ORC1L
CDC45L
TFDP1
CDK7
Cdk
RCJMB04_30p22
ORC5L
CCNE1
MDM2
TP53
CREB3L3
RPA1
CDK4
CDKN2B
CDK6
MNAT1
CCNE2
CDKN1A
POLE2
E2f
CCNE1
CCNH
CREB3L1
RB1
RB1
TFDP2
E2F6
CDK
CDK4
CREB1
POLA2
CDK6
CCNB1
MCM3
CREBL1
CCND1
CDK7
GADD45A
TPTE
CDK2
RBL1
MCM6
CDKN2D
Cdk
E2F1
RPA3
RCJMB04_6d17
PRIM2
CREB3
CDK
CCNE1
E2F2
ORC4L
CDKN2A
Description
No description
Comments
GenMAPP notes
Adapted from
http://www.genomeknowledge.org/
, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP45(r20771)
with a 66% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
95750
view
13:54, 19 January 2018
Mkutmon
Homology conversion update
74229
view
16:23, 8 April 2014
Egonw
Removed a data source where no ID was given.
68801
view
17:14, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67271
view
10:29, 26 June 2013
Christine Chichester
Ontology Term : 'G1/S DNA damage checkpoint pathway' added !
47792
view
16:31, 6 April 2012
Khanspers
updated xrefs
40934
view
22:52, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35830
view
22:15, 17 February 2010
Khanspers
Added lit ref
35829
view
22:14, 17 February 2010
Khanspers
Modified description
33865
view
17:48, 9 December 2009
MaintBot
Automatic update of empty xrefs
33510
view
15:16, 30 November 2009
MaintBot
Removed group label
31551
view
21:52, 13 August 2009
MaintBot
Fixed text labels
30409
view
21:12, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATM
GeneProduct
395401 (Entrez Gene)
CCNA1
GeneProduct
418901 (Entrez Gene)
CCNB1
GeneProduct
CCND1
GeneProduct
396341 (Entrez Gene)
CCND2
GeneProduct
374047 (Entrez Gene)
CCND3
GeneProduct
419928 (Entrez Gene)
CCNE1
GeneProduct
426117 (Entrez Gene)
CCNE2
GeneProduct
420231 (Entrez Gene)
CCNG2
GeneProduct
422512 (Entrez Gene)
CCNH
GeneProduct
427328 (Entrez Gene)
CDC25A
GeneProduct
420375 (Entrez Gene)
CDC45L
GeneProduct
416776 (Entrez Gene)
CDK
GeneProduct
CDK2
GeneProduct
CDK4
GeneProduct
CDK6
GeneProduct
420558 (Entrez Gene)
CDK7
GeneProduct
771294 (Entrez Gene)
CDKN1A
GeneProduct
CDKN1B
GeneProduct
769872 (Entrez Gene)
CDKN1C
GeneProduct
CDKN2A
GeneProduct
395077 (Entrez Gene)
CDKN2B
GeneProduct
395076 (Entrez Gene)
CDKN2C
GeneProduct
429104 (Entrez Gene)
CDKN2D
GeneProduct
CREB1
GeneProduct
395099 (Entrez Gene)
CREB3
GeneProduct
427417 (Entrez Gene)
CREB3L1
GeneProduct
423198 (Entrez Gene)
CREB3L3
GeneProduct
428333 (Entrez Gene)
CREB3L4
GeneProduct
CREBL1
GeneProduct
Cdk
GeneProduct
CyclinD
GeneProduct
E2F1
GeneProduct
396142 (Entrez Gene)
E2F2
GeneProduct
E2F3
GeneProduct
420824 (Entrez Gene)
E2F4
GeneProduct
769430 (Entrez Gene)
E2F6
GeneProduct
E2f
GeneProduct
GADD45A
GeneProduct
693255 (Entrez Gene)
MCM2
GeneProduct
416027 (Entrez Gene)
MCM3
GeneProduct
422043 (Entrez Gene)
MCM4
GeneProduct
426764 (Entrez Gene)
MCM5
GeneProduct
418058 (Entrez Gene)
MCM6
GeneProduct
424295 (Entrez Gene)
MCM7
GeneProduct
MDM2
GeneProduct
395609 (Entrez Gene)
MNAT1
GeneProduct
423521 (Entrez Gene)
MYC
GeneProduct
420332 (Entrez Gene)
MYT1
GeneProduct
419249 (Entrez Gene)
ORC1L
GeneProduct
424640 (Entrez Gene)
ORC2L
GeneProduct
424077 (Entrez Gene)
ORC3L
GeneProduct
421822 (Entrez Gene)
ORC4L
GeneProduct
424307 (Entrez Gene)
ORC5L
GeneProduct
417714 (Entrez Gene)
ORC6L
GeneProduct
415749 (Entrez Gene)
PCNA
GeneProduct
373984 (Entrez Gene)
POLA2
GeneProduct
POLE2
GeneProduct
423567 (Entrez Gene)
POLE
GeneProduct
416997 (Entrez Gene)
PRIM1
GeneProduct
426646 (Entrez Gene)
PRIM2
GeneProduct
421878 (Entrez Gene)
RB1
GeneProduct
386582 (Entrez Gene)
RBL1
GeneProduct
419126 (Entrez Gene)
RCJMB04_30p22
GeneProduct
420206 (Entrez Gene)
RCJMB04_6d17
GeneProduct
419566 (Entrez Gene)
RPA1
GeneProduct
417563 (Entrez Gene)
RPA3
GeneProduct
420578 (Entrez Gene)
TFDP1
GeneProduct
418739 (Entrez Gene)
TFDP2
GeneProduct
424780 (Entrez Gene)
TP53
GeneProduct
396200 (Entrez Gene)
TPTE
GeneProduct
418885 (Entrez Gene)
WEE1
GeneProduct
423045 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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