Cell cycle (Gallus gallus)
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1
proteolysis
DNA
+p
S
+u
+p
+p
Apoptosis
p21
+p
+u
Securin
+p
+p
Separin
+u
e
+p
Growth Factor
withdrawal
e
+p
G2
(Start)
+p
e
G1
ORC (Origin
Recognition complex)
DNA damage checkpoint
DNA
Histone Deacetylases
M
+p
MAPK
+p
Condensin
DNA biosynthesis
+p
Ubiquitin
p16,15,18,19
pathway
HDAC
Growth Factor
+u
mediated
-p
+p
+p
+p
R-point
MCM (Mini-Chromosome
Maintenance) complex
S-phase proteins
+u
-p
p27,57
+p
+p
signaling
Transcription Factor E2F
e
e
ATM
SMC1L1
PRKDC
TFDP1
ORC5L
ORC2L
TGFB1
HDAC4
CCNE2
TBC1D8
BUB3
CDC20
CDC2
UBE2F
CDH1
HDAC2
PKMYT1
E2F1
E2F
WEE1
ARF
14-3-3
HDAC5
APC/C
E2F4
CDC25C
CDK2
MPEG1
GADD45A
MCM3
MAD2L1
CDC14C
MCM5
MDM2
CDKN1B
DBF4
ORC
ORC4L
BUB1
PLK1
CDKN1A
TP53
CDKN2A
MAD2L2
CCNE1
HDAC6
CCND3
CDK6
E2F2
PTTG2
MCM
CHEK2
CCNA2
GeneProduct
HDAC8
CDC45L
HDAC7A
SCF
CCNB1
MCM7
E2F3
SCF
CDC2
SKP2
PCNA
CCNA1
APC/C
ATR
SKP2
SMAD4
BUB1B
RCJMB04_5e12
RB1
CCNB3
HDAC1
CDC14A
CDC25A
ORC1L
MCM2
CCNB2
GSK3B
MEN
CCNA1
CDK4
EP300
CCNA2
MAD1L1
PTTG3
RBL1
CDC25B
RCJMB04_30p22
ORC6L
ABL1
CDK2
CDK2
MCM4
CCNH
CDC6
PTTG1
CDC7
CHEK1
RB1
CCND2
RB1
SMAD3
HDAC3
E2F6
ORC3L
RBL1
ESPL1
MCM6
Description
No description
Comments
GenMAPP notes
Adapted from:
http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
GenMAPP remarks
Right-click here to see notes
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP179(r30295)
with a 62% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
109474
view
11:09, 18 March 2020
L Dupuis
Converted interaction lines to graphical lines where applicable
86991
view
14:37, 15 July 2016
Mkutmon
Ontology Term : 'cell cycle pathway' added !
72064
view
17:30, 24 October 2013
MaintBot
removed data source from nodes without identifier
68856
view
17:20, 8 July 2013
MaintBot
Updated to 2013 gpml schema
62677
view
18:31, 1 May 2013
MaintBot
Updated Ensembl and UniProt data source
40994
view
22:56, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35366
view
09:15, 12 February 2010
MartijnVanIersel
Modified description
33916
view
18:05, 9 December 2009
MaintBot
Automatic update of empty xrefs
33514
view
15:18, 30 November 2009
MaintBot
Removed group label
31554
view
21:53, 13 August 2009
MaintBot
Fixed text labels
30413
view
21:14, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
14-3-3
GeneProduct
ABL1
GeneProduct
417181 (Entrez Gene)
ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/C
GeneProduct
ARF
GeneProduct
ATM
GeneProduct
395401 (Entrez Gene)
ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATR
GeneProduct
424777 (Entrez Gene)
ATR; ataxia telangiectasia and Rad3 related
BUB1
GeneProduct
421226 (Entrez Gene)
BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1B
GeneProduct
378922 (Entrez Gene)
BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3
GeneProduct
423949 (Entrez Gene)
BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1
GeneProduct
418901 (Entrez Gene)
CCNA1; cyclin A1
CCNA2
GeneProduct
396172 (Entrez Gene)
CCNA2; cyclin A2
CCNB1
GeneProduct
CCNB1; cyclin B1
CCNB2
GeneProduct
415400 (Entrez Gene)
CCNB2; cyclin B2
CCNB3
GeneProduct
CCNB3; cyclin B
CCND2
GeneProduct
374047 (Entrez Gene)
CCND2; cyclin D2
CCND3
GeneProduct
419928 (Entrez Gene)
CCND3; cyclin D3
CCNE1
GeneProduct
426117 (Entrez Gene)
CCNE1; cyclin E
CCNE2
GeneProduct
420231 (Entrez Gene)
CCNE2; cyclin E
CCNH
GeneProduct
427328 (Entrez Gene)
CCNH; cyclin H
CDC14A
GeneProduct
424466 (Entrez Gene)
CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14C
GeneProduct
427473 (Entrez Gene)
CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20
GeneProduct
424563 (Entrez Gene)
CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2
GeneProduct
396252 (Entrez Gene)
CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25A
GeneProduct
420375 (Entrez Gene)
CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25B
GeneProduct
CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25C
GeneProduct
CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC45L
GeneProduct
416776 (Entrez Gene)
CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6
GeneProduct
CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7
GeneProduct
424507 (Entrez Gene)
CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1
GeneProduct
415860 (Entrez Gene)
CDK2
GeneProduct
CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4
GeneProduct
CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6
GeneProduct
420558 (Entrez Gene)
CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1A
GeneProduct
CDKN1B
GeneProduct
769872 (Entrez Gene)
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2A
GeneProduct
395077 (Entrez Gene)
CHEK1
GeneProduct
CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2
GeneProduct
768913 (Entrez Gene)
CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4
GeneProduct
420536 (Entrez Gene)
ASK; activator of S phase kinas
E2F
GeneProduct
E2F1
GeneProduct
396142 (Entrez Gene)
E2F1; E2F transcription factor 1
E2F2
GeneProduct
E2F2; E2F transcription factor 2
E2F3
GeneProduct
420824 (Entrez Gene)
E2F3; E2F transcription factor 3
E2F4
GeneProduct
769430 (Entrez Gene)
E2F4; E2F transcription factor 4 p107/p130-binding
E2F6
GeneProduct
E2F6; E2F transcription factor 6
EP300
GeneProduct
418000 (Entrez Gene)
EP300; E1A binding protein p300
ESPL1
GeneProduct
425536 (Entrez Gene)
ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45A
GeneProduct
693255 (Entrez Gene)
GSK3B
GeneProduct
418335 (Entrez Gene)
GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProduct
GeneProduct
HDAC1
GeneProduct
373961 (Entrez Gene)
HDAC1; histone deacetylase 1
HDAC2
GeneProduct
395635 (Entrez Gene)
HDAC2; histone deacetylase 2
HDAC3
GeneProduct
395506 (Entrez Gene)
HDAC3; histone deacetylase 3
HDAC4
GeneProduct
374207 (Entrez Gene)
HDAC4; histone deacetylase 4
HDAC5
GeneProduct
HDAC5; histone deacetylase 5
HDAC6
GeneProduct
HDAC6; histone deacetylase 6
HDAC7A
GeneProduct
426885 (Entrez Gene)
HDAC7A; histone deacetylase 7
HDAC8
GeneProduct
422182 (Entrez Gene)
HDAC8; histone deacetylase
MAD1L1
GeneProduct
427658 (Entrez Gene)
MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1
GeneProduct
422675 (Entrez Gene)
MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2
GeneProduct
419493 (Entrez Gene)
MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCM
GeneProduct
MCM2
GeneProduct
416027 (Entrez Gene)
MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3
GeneProduct
422043 (Entrez Gene)
MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4
GeneProduct
426764 (Entrez Gene)
MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5
GeneProduct
418058 (Entrez Gene)
MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6
GeneProduct
424295 (Entrez Gene)
MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7
GeneProduct
MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2
GeneProduct
395609 (Entrez Gene)
MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MEN
GeneProduct
MPEG1
GeneProduct
ORC
GeneProduct
ORC1L
GeneProduct
424640 (Entrez Gene)
ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2L
GeneProduct
424077 (Entrez Gene)
ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3L
GeneProduct
421822 (Entrez Gene)
ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4L
GeneProduct
424307 (Entrez Gene)
ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5L
GeneProduct
417714 (Entrez Gene)
ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6L
GeneProduct
415749 (Entrez Gene)
ORC6L; origin recognition complex subunit 6-like (yeast)
PCNA
GeneProduct
373984 (Entrez Gene)
PCNA; proliferating cell nuclear antigen
PKMYT1
GeneProduct
PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1
GeneProduct
416575 (Entrez Gene)
PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDC
GeneProduct
395376 (Entrez Gene)
PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1
GeneProduct
416158 (Entrez Gene)
PTTG1; pituitary tumor-transforming
PTTG2
GeneProduct
PTTG2; pituitary tumor-transforming
PTTG3
GeneProduct
PTTG3; pituitary tumor-transforming
RB1
GeneProduct
386582 (Entrez Gene)
RB1; retinoblastoma 1 (including osteosarcoma)
RBL1
GeneProduct
419126 (Entrez Gene)
RBL1; retinoblastoma-like 1 (p107)
RCJMB04_30p22
GeneProduct
420206 (Entrez Gene)
E2F5; E2F transcription factor 5 p130-binding
RCJMB04_5e12
GeneProduct
427820 (Entrez Gene)
YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
SCF
GeneProduct
SKP2
GeneProduct
427437 (Entrez Gene)
SKP2; S-phase kinase-associated protein 2 (p45
SMAD3
GeneProduct
395132 (Entrez Gene)
MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4
GeneProduct
MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1L1
GeneProduct
SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8
GeneProduct
428012 (Entrez Gene)
TFDP1
GeneProduct
418739 (Entrez Gene)
TFDP1; transcription factor Dp-1
TGFB1
GeneProduct
TP53
GeneProduct
396200 (Entrez Gene)
UBE2F
GeneProduct
424015 (Entrez Gene)
UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1
GeneProduct
423045 (Entrez Gene)
WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
Annotated Interactions
No annotated interactions
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DataNodes
Annotated Interactions
No annotated interactions