Metapathway biotransformation (Rattus norvegicus)
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Glutathione conjugation
Electrophiles
Acetylation
Amino acid acyl transferases
Methyltransferases
Aldo-keto reductases
Glutathione reductase
Sulfation
Glutathione peroxidases
Cytochrome P450
Glutathione transferases
Nucleophiles
Sulfotransferases
Flavin monooxygenases
Glucuronosyltransferases
Glutathione synthetase
Epoxide hydrolases
Methylation
Reduction
Hydrolysis
Oxidation
N-acetyltransferases
Glucuronidation
Amino acid conjugation
MGC108896
Baat
NP_001099351.1
Cyp1a1
Ugt1a3
Cyp8b1
NP_001100974.1
SULT1C2
Substrate-CH3
Cyp2w1_predicted
CYP2C19
Gstk1
Glyat
SULT1C4
Cyp1b1
Xenobiotic substrate
Ephx2
Sult1a1
CYP3A5
AKR1B1
GSTA5
NP_001102193.1
UGT1A10
Kcnab1
Ndst3_predicted
Cyp2u1
LOC681900
NAT8
MGC105600
CYP27B1
Fmo2
Cyp2e1
HS6ST3
CYP4Z1
Glucuronosyltransferase
CYP4F11
AKR1C4
SULT1C1
Fmo1
NP_001100901.1
Mgst1
Ndst4_predicted
Cyp20a1
LOC690611
AKR1C1
UGT2A2
Sult1a1
Cyp19a1
Fmo5
CYP27C1
Glutathione transferase
Kcnab2
Cyp1a2
Chst10
Cyp26b1
Sult1a1
Akr1a1
NAT6
UGT2B28
Tpmt
CYP2A13
Aldo-keto reductase
Ugt1a2
CYP2C8
NP_001101969.1
CYP4X1
Gm766
Cyp17a1
HS3ST3B1
CYP4F8
Cyp4b1
CYP3A4
Nat8l_predicted
CHST12
GPX2
RGD1562825_predicted
Akr7a3
Ste
Ndst1
UGT1A9
MGST3
NP_001101226.1
CYP2C9
CHSTB_RAT
Chst1
NP_001100363.1
Sult1b1
Substrate-Ac
Methyltransferase
Substrate-NH2
Ugt1a3
NP_001100897.1
Gstp2
NP_001099210.1
Substrate-Gl
Chst3
Flavin monooxygenase
Chst2_predicted
Akr7a2
CYP2A6
HS3ST3A1
Substrate-OH
GSTA1
Cyp21a1
UGT2B4
Hs2st1
Gpx3
CYP11B2
Hs3st4
NP_001102065.1
NP_001101195.1
Gstm5
CYP2C18
Gpx5
Hnmt
CYP4F2
NP_001100289.1
GPX1
Hs3st2
Chst14
Cyp2f2
Fmo3
NP_001101680.1
ST2B1_RAT
CYP2D6
Chst7
Cyp24a1
AKR1B10
CYP11B1
Cyp4f39_predicted
GSTM5
Substrate-SO3H
Substrate=O
Kcnab3
Nat9_predicted
Gsto2
Gstt2
Mgst2
UGT1A7
GSTA4
CYP4F12
Gsto1
NP_001101936.1
Akr1d1
Ugt1a5
NP_001102569.1
Substrate-O-R
UGT2B15
LOC687052
Hs3st1
N-acetyltransferase
Gsr
CYP4V2
Sulfotransferase
SULT2A1
AKR1C3
NP_001102492.1
CYP2J2
Comt
Cyp7a1
GAL3ST1
CYP2A7
Ephx1
Ugt2a1
Substrate-SG
Gstt1
UGT2B7
Cyp26c1_predicted
NP_001101988.1
UGT2B17
LOC685402
Cyp26a1
Fmo4
Substrate-Aa
Ugt1a6
GLYATL1
LOC683774
NAT2
NAT1
NP_001100901.1
Ugt1a1
GSTM1
Sult1a1
Cyp4f18
NP_001099862.1
GSTA2
Ugt2a3_predicted
CYP3A43
GSTA3
Cyp11a1
UGT2B11
Substrate-SH
GLYATL2
Gstt2
CYP2B6
Cyp51
CYP450
Gstm3
NP_001102534.1
Cyp27a1
GSTZ1
AKR1C2
Sult1c1
Gss
CYP3A7
Chst9
Amino acid acyltransferase
Cyp7b1
SULT4A1
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP702(r29945)
with a 60% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
125510
view
01:44, 24 February 2023
AlexanderPico
Modified description
69345
view
18:52, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67457
view
11:04, 26 June 2013
Ddigles
Ontology Term : 'cellular detoxification pathway' added !
58921
view
05:10, 21 February 2013
MaintBot
Updated Ensembl and UniProt data source
58518
view
20:07, 14 February 2013
MaintBot
Modified title
41657
view
02:34, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34055
view
19:04, 9 December 2009
MaintBot
Automatic update of empty xrefs
33192
view
18:08, 5 November 2009
Khanspers
Modified categories
32303
view
13:17, 15 August 2009
MaintBot
Fixed text labels
31886
view
12:42, 14 August 2009
MaintBot
Fixed group labels
31332
view
20:22, 13 August 2009
MaintBot
Fixed text labels
30952
view
00:43, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKR1B10
GeneProduct
296972 (Entrez Gene)
AKR1B1
GeneProduct
24192 (Entrez Gene)
AKR1C1
GeneProduct
307092 (Entrez Gene)
AKR1C2
GeneProduct
AKR1C3
GeneProduct
AKR1C4
GeneProduct
Akr1a1
GeneProduct
ENSRNOG00000016727 (Ensembl Rat)
Akr1d1
GeneProduct
ENSRNOG00000013004 (Ensembl Rat)
Akr7a2
GeneProduct
ENSRNOG00000017780 (Ensembl Rat)
Akr7a3
GeneProduct
ENSRNOG00000017899 (Ensembl Rat)
Aldo-keto reductase
GeneProduct
Amino acid acyltransferase
GeneProduct
Baat
GeneProduct
ENSRNOG00000007395 (Ensembl Rat)
CHST12
GeneProduct
304322 (Entrez Gene)
CHSTB_RAT
GeneProduct
ENSRNOG00000008885 (Ensembl Rat)
CYP11B1
GeneProduct
500892 (Entrez Gene)
CYP11B2
GeneProduct
24294 (Entrez Gene)
CYP27B1
GeneProduct
114700 (Entrez Gene)
CYP27C1
GeneProduct
CYP2A13
GeneProduct
CYP2A6
GeneProduct
CYP2A7
GeneProduct
CYP2B6
GeneProduct
CYP2C18
GeneProduct
CYP2C19
GeneProduct
CYP2C8
GeneProduct
CYP2C9
GeneProduct
CYP2D6
GeneProduct
CYP2J2
GeneProduct
CYP3A4
GeneProduct
CYP3A43
GeneProduct
CYP3A5
GeneProduct
CYP3A7
GeneProduct
CYP450
GeneProduct
CYP4F11
GeneProduct
CYP4F12
GeneProduct
CYP4F2
GeneProduct
CYP4F8
GeneProduct
CYP4V2
GeneProduct
CYP4X1
GeneProduct
246767 (Entrez Gene)
CYP4Z1
GeneProduct
Chst10
GeneProduct
ENSRNOG00000012815 (Ensembl Rat)
Chst14
GeneProduct
691394 (Entrez Gene)
Chst1
GeneProduct
ENSRNOG00000007989 (Ensembl Rat)
Chst2_predicted
GeneProduct
ENSRNOG00000037453 (Ensembl Rat)
Chst3
GeneProduct
ENSRNOG00000000572 (Ensembl Rat)
Chst7
GeneProduct
ENSRNOG00000004258 (Ensembl Rat)
Chst9
GeneProduct
291770 (Entrez Gene)
Comt
GeneProduct
ENSRNOG00000001889 (Ensembl Rat)
Cyp11a1
GeneProduct
ENSRNOG00000008074 (Ensembl Rat)
Cyp17a1
GeneProduct
ENSRNOG00000020035 (Ensembl Rat)
Cyp19a1
GeneProduct
ENSRNOG00000000196 (Ensembl Rat)
Cyp1a1
GeneProduct
ENSRNOG00000019500 (Ensembl Rat)
Cyp1a2
GeneProduct
ENSRNOG00000016173 (Ensembl Rat)
Cyp1b1
GeneProduct
ENSRNOG00000040287 (Ensembl Rat)
Cyp20a1
GeneProduct
ENSRNOG00000017631 (Ensembl Rat)
Cyp21a1
GeneProduct
24298 (Entrez Gene)
Cyp24a1
GeneProduct
ENSRNOG00000013062 (Ensembl Rat)
Cyp26a1
GeneProduct
ENSRNOG00000016750 (Ensembl Rat)
Cyp26b1
GeneProduct
ENSRNOG00000015076 (Ensembl Rat)
Cyp26c1_predicted
GeneProduct
ENSRNOG00000030698 (Ensembl Rat)
Cyp27a1
GeneProduct
ENSRNOG00000017188 (Ensembl Rat)
Cyp2e1
GeneProduct
ENSRNOG00000012458 (Ensembl Rat)
Cyp2f2
GeneProduct
ENSRNOG00000032805 (Ensembl Rat)
Cyp2u1
GeneProduct
ENSRNOG00000011053 (Ensembl Rat)
Cyp2w1_predicted
GeneProduct
ENSRNOG00000022355 (Ensembl Rat)
Cyp4b1
GeneProduct
ENSRNOG00000009741 (Ensembl Rat)
Cyp4f18
GeneProduct
ENSRNOG00000015751 (Ensembl Rat)
Cyp4f39_predicted
GeneProduct
ENSRNOG00000029478 (Ensembl Rat)
Cyp51
GeneProduct
ENSRNOG00000007234 (Ensembl Rat)
Cyp7a1
GeneProduct
ENSRNOG00000009488 (Ensembl Rat)
Cyp7b1
GeneProduct
ENSRNOG00000009730 (Ensembl Rat)
Cyp8b1
GeneProduct
ENSRNOG00000019481 (Ensembl Rat)
Ephx1
GeneProduct
ENSRNOG00000003515 (Ensembl Rat)
Ephx2
GeneProduct
ENSRNOG00000017286 (Ensembl Rat)
Flavin monooxygenase
GeneProduct
Fmo1
GeneProduct
ENSRNOG00000034191 (Ensembl Rat)
Fmo2
GeneProduct
ENSRNOG00000003510 (Ensembl Rat)
Fmo3
GeneProduct
ENSRNOG00000003620 (Ensembl Rat)
Fmo4
GeneProduct
ENSRNOG00000003400 (Ensembl Rat)
Fmo5
GeneProduct
ENSRNOG00000018076 (Ensembl Rat)
GAL3ST1
GeneProduct
GLYATL1
GeneProduct
GLYATL2
GeneProduct
GPX1
GeneProduct
24404 (Entrez Gene)
GPX2
GeneProduct
29326 (Entrez Gene)
GSTA1
GeneProduct
GSTA2
GeneProduct
24422 (Entrez Gene)
GSTA3
GeneProduct
24421 (Entrez Gene)
GSTA4
GeneProduct
300850 (Entrez Gene)
GSTA5
GeneProduct
GSTM1
GeneProduct
24423 (Entrez Gene)
GSTM5
GeneProduct
64352 (Entrez Gene)
GSTZ1
GeneProduct
681913 (Entrez Gene)
Glucuronosyltransferase
GeneProduct
Glutathione transferase
GeneProduct
Glyat
GeneProduct
ENSRNOG00000012142 (Ensembl Rat)
Gm766
GeneProduct
ENSRNOG00000036959 (Ensembl Rat)
Gpx3
GeneProduct
ENSRNOG00000021809 (Ensembl Rat)
Gpx5
GeneProduct
ENSRNOG00000018596 (Ensembl Rat)
Gsr
GeneProduct
ENSRNOG00000014915 (Ensembl Rat)
Gss
GeneProduct
ENSRNOG00000018964 (Ensembl Rat)
Gstk1
GeneProduct
ENSRNOG00000016484 (Ensembl Rat)
Gstm3
GeneProduct
ENSRNOG00000018937 (Ensembl Rat)
Gstm5
GeneProduct
ENSRNOG00000018732 (Ensembl Rat)
Gsto1
GeneProduct
ENSRNOG00000028746 (Ensembl Rat)
Gsto2
GeneProduct
ENSRNOG00000012801 (Ensembl Rat)
Gstp2
GeneProduct
ENSRNOG00000018237 (Ensembl Rat)
Gstt1
GeneProduct
ENSRNOG00000001242 (Ensembl Rat)
Gstt2
GeneProduct
ENSRNOG00000028188 (Ensembl Rat)
HS3ST3A1
GeneProduct
363618 (Entrez Gene)
HS3ST3B1
GeneProduct
303218 (Entrez Gene)
HS6ST3
GeneProduct
364476 (Entrez Gene)
Hnmt
GeneProduct
ENSRNOG00000005223 (Ensembl Rat)
Hs2st1
GeneProduct
ENSRNOG00000012549 (Ensembl Rat)
Hs3st1
GeneProduct
ENSRNOG00000010598 (Ensembl Rat)
Hs3st2
GeneProduct
ENSRNOG00000017659 (Ensembl Rat)
Hs3st4
GeneProduct
ENSRNOG00000036723 (Ensembl Rat)
Kcnab1
GeneProduct
ENSRNOG00000010422 (Ensembl Rat)
Kcnab2
GeneProduct
ENSRNOG00000011550 (Ensembl Rat)
Kcnab3
GeneProduct
ENSRNOG00000008480 (Ensembl Rat)
LOC681900
GeneProduct
ENSRNOG00000014672 (Ensembl Rat)
LOC683774
GeneProduct
ENSRNOG00000030880 (Ensembl Rat)
LOC685402
GeneProduct
ENSRNOG00000022982 (Ensembl Rat)
LOC687052
GeneProduct
ENSRNOG00000020743 (Ensembl Rat)
LOC690611
GeneProduct
ENSRNOG00000013604 (Ensembl Rat)
MGC105600
GeneProduct
ENSRNOG00000028743 (Ensembl Rat)
MGC108896
GeneProduct
ENSRNOG00000019221 (Ensembl Rat)
MGST3
GeneProduct
289197 (Entrez Gene)
Methyltransferase
GeneProduct
Mgst1
GeneProduct
ENSRNOG00000007743 (Ensembl Rat)
Mgst2
GeneProduct
ENSRNOG00000013296 (Ensembl Rat)
N-acetyltransferase
GeneProduct
NAT1
GeneProduct
116631 (Entrez Gene)
NAT2
GeneProduct
116632 (Entrez Gene)
NAT6
GeneProduct
NAT8
GeneProduct
64570 (Entrez Gene)
NP_001099210.1
GeneProduct
ENSRNOG00000027171 (Ensembl Rat)
NP_001099351.1
GeneProduct
ENSRNOG00000039017 (Ensembl Rat)
NP_001099862.1
GeneProduct
ENSRNOG00000000605 (Ensembl Rat)
NP_001100289.1
GeneProduct
ENSRNOG00000005930 (Ensembl Rat)
NP_001100363.1
GeneProduct
ENSRNOG00000010519 (Ensembl Rat)
NP_001100897.1
GeneProduct
ENSRNOG00000016953 (Ensembl Rat)
NP_001100901.1
GeneProduct
ENSRNOG00000021521 (Ensembl Rat)
NP_001100974.1
GeneProduct
ENSRNOG00000022919 (Ensembl Rat)
NP_001101195.1
GeneProduct
ENSRNOG00000011669 (Ensembl Rat)
NP_001101226.1
GeneProduct
ENSRNOG00000008663 (Ensembl Rat)
NP_001101680.1
GeneProduct
ENSRNOG00000014516 (Ensembl Rat)
NP_001101936.1
GeneProduct
ENSRNOG00000038622 (Ensembl Rat)
NP_001101969.1
GeneProduct
ENSRNOG00000011367 (Ensembl Rat)
NP_001101988.1
GeneProduct
ENSRNOG00000021179 (Ensembl Rat)
NP_001102065.1
GeneProduct
ENSRNOG00000010523 (Ensembl Rat)
NP_001102193.1
GeneProduct
ENSRNOG00000007147 (Ensembl Rat)
NP_001102492.1
GeneProduct
ENSRNOG00000011250 (Ensembl Rat)
NP_001102534.1
GeneProduct
ENSRNOG00000001375 (Ensembl Rat)
NP_001102569.1
GeneProduct
ENSRNOG00000014192 (Ensembl Rat)
Nat8l_predicted
GeneProduct
ENSRNOG00000015466 (Ensembl Rat)
Nat9_predicted
GeneProduct
ENSRNOG00000003264 (Ensembl Rat)
Ndst1
GeneProduct
ENSRNOG00000019014 (Ensembl Rat)
Ndst3_predicted
GeneProduct
ENSRNOG00000015781 (Ensembl Rat)
Ndst4_predicted
GeneProduct
ENSRNOG00000009577 (Ensembl Rat)
RGD1562825_predicted
GeneProduct
ENSRNOG00000025930 (Ensembl Rat)
ST2B1_RAT
GeneProduct
ENSRNOG00000021046 (Ensembl Rat)
SULT1C1
GeneProduct
SULT1C2
GeneProduct
171072 (Entrez Gene)
SULT1C4
GeneProduct
SULT2A1
GeneProduct
24912 (Entrez Gene)
SULT4A1
GeneProduct
58953 (Entrez Gene)
Ste
GeneProduct
ENSRNOG00000001957 (Ensembl Rat)
Substrate-Aa
Metabolite
Substrate-Ac
Metabolite
Substrate-CH3
Metabolite
Substrate-Gl
Metabolite
Substrate-NH2
Metabolite
Substrate-O-R
Metabolite
Substrate-OH
Metabolite
Substrate-SG
Metabolite
Substrate-SH
Metabolite
Substrate-SO3H
Metabolite
Substrate=O
Metabolite
Sulfotransferase
GeneProduct
Sult1a1
GeneProduct
ENSRNOG00000019342 (Ensembl Rat)
Sult1b1
GeneProduct
ENSRNOG00000001967 (Ensembl Rat)
Sult1c1
GeneProduct
ENSRNOG00000011269 (Ensembl Rat)
Tpmt
GeneProduct
ENSRNOG00000016468 (Ensembl Rat)
UGT1A10
GeneProduct
UGT1A7
GeneProduct
UGT1A9
GeneProduct
396552 (Entrez Gene)
UGT2A2
GeneProduct
UGT2B11
GeneProduct
UGT2B15
GeneProduct
UGT2B17
GeneProduct
286954 (Entrez Gene)
UGT2B28
GeneProduct
UGT2B4
GeneProduct
UGT2B7
GeneProduct
Ugt1a1
GeneProduct
24861 (Entrez Gene)
Ugt1a2
GeneProduct
396527 (Entrez Gene)
Ugt1a3
GeneProduct
396551 (Entrez Gene)
Ugt1a3
GeneProduct
ENSRNOG00000018740 (Ensembl Rat)
Ugt1a5
GeneProduct
574523 (Entrez Gene)
Ugt1a6
GeneProduct
113992 (Entrez Gene)
Ugt2a1
GeneProduct
ENSRNOG00000001973 (Ensembl Rat)
Ugt2a3_predicted
GeneProduct
ENSRNOG00000001975 (Ensembl Rat)
Xenobiotic substrate
Metabolite
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions