Statin pathway (Pan troglodytes)
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Cell Membrane
Represses
Tissues
Activates
Liver cell
Plasma
Legend
Acetyl-CoA
HDL
SOAT1
LPL
LDLR
CYP7A1
CETP
APOC3
Cholesterol ester
APOA1
LCAT
APOE
TRNP
DGAT1
Statin
SCARB1
Cholic Acid
LDL
ABCA1
Phospholipid
HMGCR
APOA4
Cholesterol
PLTP
Triglyceride
IDL
Cholesterol
LIPC
VLDL
APOC2
Fatty acid
LRP1
APOC1
Description
What are statins? See Wikipedia at:
http://en.wikipedia.org/wiki/Statin
More about this pathway and statins:
https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP430(r29996)
with a 78% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117410
view
10:39, 21 May 2021
Eweitz
Modified title
106936
view
13:40, 17 September 2019
MaintBot
HMDB identifier normalization
71660
view
19:40, 17 October 2013
MaintBot
Automated update of data sources
69229
view
18:33, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67660
view
11:45, 26 June 2013
Ddigles
Ontology Term : 'statin drug pathway' added !
41532
view
01:57, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35547
view
14:21, 12 February 2010
Thomas
added literature, cosmetic change
34268
view
21:53, 9 December 2009
MaintBot
Automatic update of empty xrefs
33576
view
09:48, 1 December 2009
MaintBot
Removed group label
30490
view
21:38, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABCA1
GeneProduct
464630 (Entrez Gene)
APOA1
GeneProduct
451564 (Entrez Gene)
APOA4
GeneProduct
466792 (Entrez Gene)
APOC1
GeneProduct
743864 (Entrez Gene)
APOC2
GeneProduct
744578 (Entrez Gene)
APOC3
GeneProduct
451563 (Entrez Gene)
APOE
GeneProduct
449586 (Entrez Gene)
Acetyl-CoA
Metabolite
HMDB01206 (HMDB)
CETP
GeneProduct
467982 (Entrez Gene)
CYP7A1
GeneProduct
464191 (Entrez Gene)
Cholesterol ester
Metabolite
C02530 (Kegg Compound)
Cholesterol
Metabolite
Cholic Acid
Metabolite
DGAT1
GeneProduct
464460 (Entrez Gene)
Fatty acid
Metabolite
C00162 (Kegg Compound)
HDL
Metabolite
C01834 (Kegg Compound)
HMGCR
GeneProduct
471516 (Entrez Gene)
IDL
Metabolite
C01834 (Kegg Compound)
LCAT
GeneProduct
743056 (Entrez Gene)
LDL
Metabolite
C01834 (Kegg Compound)
LDLR
GeneProduct
455722 (Entrez Gene)
LIPC
GeneProduct
746925 (Entrez Gene)
LPL
GeneProduct
464031 (Entrez Gene)
LRP1
GeneProduct
452006 (Entrez Gene)
PLTP
GeneProduct
458291 (Entrez Gene)
Phospholipid
Metabolite
C00865 (Kegg Compound)
SCARB1
GeneProduct
452359 (Entrez Gene)
SOAT1
GeneProduct
457553 (Entrez Gene)
Statin
Metabolite
TRNP
GeneProduct
Triglyceride
Metabolite
C00422 (Kegg Compound)
VLDL
Metabolite
C01834 (Kegg Compound)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions