Heme biosynthesis (Pan troglodytes)
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Fe2+
H+
delta-aminolevulinate
Black - reactants
protoporphyrinogen IX
succinyl-CoA + glycine
delta-aminolevulinate
Red - side products
rate limiting step
CPOX
O2
protoporphyrin IX
O2
ALAD
H2O
CO2
NH3
FECH
H2O
PPOX
H2O2
UROS
hydroxymethylbilane
CO2
ALAS1
CO2
UROD
porphobilinogen
uroporphyrinogen III
HMBS
protoheme
coproporphyrinogen III
CoA
ALAS2
H2O
Porphobilinogen
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP561(r21860)
with a 60% conversion rate.
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
117403
view
10:36, 21 May 2021
Eweitz
Modified title
106914
view
13:38, 17 September 2019
MaintBot
HMDB identifier normalization
89924
view
13:34, 6 October 2016
Mkutmon
Modified description
88639
view
14:51, 12 August 2016
Jmelius
Ontology Term : 'heme biosynthetic pathway' added !
71958
view
23:27, 23 October 2013
MaintBot
removed data source from nodes without identifier
69997
view
22:33, 11 July 2013
MaintBot
updated to 2013 schema
41533
view
01:57, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35291
view
22:53, 11 February 2010
Mills42
Modified description
34269
view
21:53, 9 December 2009
MaintBot
Automatic update of empty xrefs
33518
view
15:20, 30 November 2009
MaintBot
Removed group label
30417
view
21:15, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ALAD
GeneProduct
464675 (Entrez Gene)
ALAS1
GeneProduct
460416 (Entrez Gene)
ALAS2
GeneProduct
473626 (Entrez Gene)
CO2
Metabolite
HMDB01967 (HMDB)
CPOX
GeneProduct
460544 (Entrez Gene)
CoA
Metabolite
HMDB01423 (HMDB)
FECH
GeneProduct
455437 (Entrez Gene)
H2O2
Metabolite
HMDB03125 (HMDB)
H2O
Metabolite
HMDB02111 (HMDB)
HMBS
GeneProduct
744366 (Entrez Gene)
NH3
Metabolite
HMDB00051 (HMDB)
O2
Metabolite
HMDB01377 (HMDB)
PPOX
GeneProduct
457450 (Entrez Gene)
Porphobilinogen
Metabolite
HMDB00245 (HMDB)
UROD
GeneProduct
456541 (Entrez Gene)
UROS
GeneProduct
450813 (Entrez Gene)
coproporphyrinogen III
Metabolite
hydroxymethylbilane
Metabolite
porphobilinogen
Metabolite
protoheme
Metabolite
protoporphyrin IX
Metabolite
uroporphyrinogen III
Metabolite
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions