MAPK signaling pathway (Pan troglodytes)

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1DNAProliferation, inflammation, anti-apoptosisMAPKKSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressDNA damageDNADNADNAHeteromeric G-proteinProliferation, differentiationPhosphatidylinositolsignaling systemLPSJNK & p38 MAP kinase pathwayCellPTPp38Wnt signaling pathwayMAPKProliferation, differentiation,inflammationPTPp53 signaling pathwayProliferation, differentiationCycleDNAClassical MAP kinase PathwayIP3ERK5 pathwayMAPKKKDAGCa2+ApoptosisJNKMKPMAPKKKKTranscription factorsSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamKRASARRB2IKBKGMAPK6MAPTPRKCDPPM1BRAC1SOS2MAPK8MAP3K4MAPK13PTPRRDAXXZAKCASP2MAP4K1RAC2MAP4K4IL1APDGFBMAP2K7CRKMAP4K3JUNDMINK1NF1SRFTRAF6ATF4CTP53Sap1aAKT3MAPK4DUSP4CASP7PRKCDCRKLMAPKAPK5FGF4CASP8sap1aMAP3K6NGFAKT2CDC42MEF2Cmnk1/2AKT1ECSITRAF1CASP9PTPN7FASMAP3K8ACVR1CRHOXF2nfat2/4HSPA8MAPK3MAP2K1TGFB2PTPN7PLA2G10NTRK1RPS6KA3CASP6HSPA5TAOK1MAP3K5RAP1BPTPRRMEKK2/3PLA2G5DUSP1GCKDUSP7PRKCGCDC25BMAPK8IP3FASLGDUSP5DUSP6PPP3R2msk1/2PPP3CAEGFHSPB1IL1R1HSPA1AMOSPDGFRBNRASTGFBR1fgfrMAP2K2NTF4PPP3R1ATF4CTRAF2CD14ATF2cAMPSTMN1PPM1ANLKMAP2K4ACVR1BIL1Bmkk3RASGRP1MAP3K1TMEM37BDNFRASA1RASGRF2DDIT3PRKCZPRKACAPTPN5GRB2PPP5CRASGRP4IKBKBMAP3K11MAP3K14CASP3GADD45AHSPB2PPP3CBTGFB1RAP1AMAP2K6NR4A1MAP3K7TNFRASA2MYCTGFBR2MAPK14MAPK12MAP3K7IP2PTPN5FOSTAOK2FLNACASP1MAPK10ELK1DUSP10TGFB3MAPK1JUNEGFRSTK3MAPK7PAK2GNA12IL1R2MAPK9PRKCB1MAP3K12MAP3K13MRASPPP3CCPAK1MAP3K7IP1MAPKAPK2PRKCHBRAFMAP2K5MAXNFKB1ARRB1MAPKSP1


Description

No description

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP382(r28779) with a 78% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia
  2. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC Scholia
  3. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC Scholia
  4. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC Scholia
  5. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC Scholia
  6. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC Scholia
  7. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC Scholia
  8. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC Scholia
  9. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC Scholia
  10. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC Scholia
  11. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116816view10:14, 14 May 2021EweitzModified title
111166view10:02, 21 July 2020EgonwMade a few more pathways clickable
106924view13:39, 17 September 2019MaintBotHMDB identifier normalization
105690view21:01, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96307view18:38, 7 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95782view14:34, 19 January 2018MkutmonHomology conversion update
72136view09:35, 25 October 2013Mkutmonadded datasource to pathway datanodes
69238view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67447view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
48170view20:32, 9 May 2012MaintBotUpdating from human to fix xrefs
41542view01:58, 2 March 2011MaintBotRemoved redundant pathway information and comments
35666view22:31, 12 February 2010KhanspersDescription and Bibliography
34274view21:55, 9 December 2009MaintBotAutomatic update of empty xrefs
33545view09:39, 1 December 2009MaintBotRemoved group label
31574view22:00, 13 August 2009MaintBotFixed text labels
30449view21:25, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVR1BGeneProduct451911 (Entrez Gene)
ACVR1CGeneProduct470564 (Entrez Gene)
AKT1GeneProduct740898 (Entrez Gene)
AKT2GeneProduct456035 (Entrez Gene)
AKT3GeneProduct735718 (Entrez Gene)
ARRB1GeneProduct451424 (Entrez Gene)
ARRB2GeneProduct454450 (Entrez Gene)
ATF2GeneProduct
ATF4CGeneProduct468334 (Entrez Gene)
BDNFGeneProduct503511 (Entrez Gene)
BRAFGeneProduct463781 (Entrez Gene)
CASP1GeneProduct451519 (Entrez Gene)
CASP2GeneProduct463804 (Entrez Gene)
CASP3GeneProduct461669 (Entrez Gene)
CASP6GeneProduct736606 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP8GeneProduct746477 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CD14GeneProduct462118 (Entrez Gene)
CDC25BGeneProduct458064 (Entrez Gene)
CDC42GeneProduct456609 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
DAXXGeneProduct462613 (Entrez Gene)
DDIT3GeneProduct452017 (Entrez Gene)
DUSP10GeneProduct469145 (Entrez Gene)
DUSP1GeneProduct471742 (Entrez Gene)
DUSP4GeneProduct464497 (Entrez Gene)
DUSP5GeneProduct
DUSP6GeneProduct452115 (Entrez Gene)
DUSP7GeneProduct470826 (Entrez Gene)
ECSITGeneProduct455733 (Entrez Gene)
EGFGeneProduct461435 (Entrez Gene)
EGFRGeneProduct463415 (Entrez Gene)
ELK1GeneProduct
FASGeneProduct738331 (Entrez Gene)
FASLGGeneProduct469584 (Entrez Gene)
FGF4GeneProduct747727 (Entrez Gene)
FLNAGeneProduct
FOSGeneProduct453047 (Entrez Gene)
GADD45AGeneProduct456929 (Entrez Gene)
GCKGeneProduct737923 (Entrez Gene)
GNA12GeneProduct463234 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
HSPA1AGeneProduct
HSPA5GeneProduct464733 (Entrez Gene)
HSPA8GeneProduct451629 (Entrez Gene)
HSPB1GeneProduct463488 (Entrez Gene)
HSPB2GeneProduct
IKBKBGeneProduct472749 (Entrez Gene)
IKBKGGeneProduct743415 (Entrez Gene)
IL1AGeneProduct470485 (Entrez Gene)
IL1BGeneProduct450200 (Entrez Gene)
IL1R1GeneProduct459460 (Entrez Gene)
IL1R2GeneProduct470455 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
JUNDGeneProduct748667 (Entrez Gene)
KRASGeneProduct473387 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP2K5GeneProduct453532 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP2K7GeneProduct743199 (Entrez Gene)
MAP3K11GeneProduct451326 (Entrez Gene)
MAP3K12GeneProduct451940 (Entrez Gene)
MAP3K13GeneProduct737524 (Entrez Gene)
MAP3K14GeneProduct
MAP3K1GeneProduct471543 (Entrez Gene)
MAP3K4GeneProduct
MAP3K5GeneProduct463023 (Entrez Gene)
MAP3K6GeneProduct456674 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAP3K7IP1GeneProduct458845 (Entrez Gene)
MAP3K7IP2GeneProduct463057 (Entrez Gene)
MAP3K8GeneProduct450384 (Entrez Gene)
MAP4K1GeneProduct748652 (Entrez Gene)
MAP4K3GeneProduct459173 (Entrez Gene)
MAP4K4GeneProduct459459 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MAPK12GeneProduct
MAPK13GeneProduct462644 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK4GeneProduct
MAPK6GeneProduct453439 (Entrez Gene)
MAPK7GeneProduct454499 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK8IP3GeneProduct453825 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MAPKAPK5GeneProduct738233 (Entrez Gene)
MAPKSP1GeneProduct461399 (Entrez Gene)
MAPTGeneProduct450177 (Entrez Gene)
MAXGeneProduct452972 (Entrez Gene)
MEF2CGeneProduct461760 (Entrez Gene)
MEKK2/3GeneProduct
MINK1GeneProduct454455 (Entrez Gene)
MOSGeneProduct472772 (Entrez Gene)
MRASGeneProduct
MYCGeneProduct464393 (Entrez Gene)
NF1GeneProduct454566 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NGFGeneProduct469423 (Entrez Gene)
NLKGeneProduct739132 (Entrez Gene)
NR4A1GeneProduct451913 (Entrez Gene)
NRASGeneProduct742713 (Entrez Gene)
NTF4GeneProduct747850 (Entrez Gene)
NTRK1GeneProduct457408 (Entrez Gene)
PAK1GeneProduct451439 (Entrez Gene)
PAK2GeneProduct460965 (Entrez Gene)
PDGFBGeneProduct458844 (Entrez Gene)
PDGFRBGeneProduct462188 (Entrez Gene)
PLA2G10GeneProduct740803 (Entrez Gene)
PLA2G5GeneProduct456588 (Entrez Gene)
PPM1AGeneProduct452950 (Entrez Gene)
PPM1BGeneProduct470365 (Entrez Gene)
PPP3CAGeneProduct461403 (Entrez Gene)
PPP3CBGeneProduct450898 (Entrez Gene)
PPP3CCGeneProduct742406 (Entrez Gene)
PPP3R1GeneProduct
PPP3R2GeneProduct736325 (Entrez Gene)
PPP5CGeneProduct456150 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PTPN5GeneProduct466462 (Entrez Gene)
PTPN7GeneProduct739158 (Entrez Gene)
PTPRRGeneProduct452076 (Entrez Gene)
RAC1GeneProduct
RAC2GeneProduct742575 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RAP1AGeneProduct469408 (Entrez Gene)
RAP1BGeneProduct452065 (Entrez Gene)
RASA1GeneProduct461762 (Entrez Gene)
RASA2GeneProduct460741 (Entrez Gene)
RASGRF2GeneProduct461771 (Entrez Gene)
RASGRP1GeneProduct453316 (Entrez Gene)
RASGRP4GeneProduct468867 (Entrez Gene)
RHOXF2GeneProduct473763 (Entrez Gene)
RPS6KA3GeneProduct450110 (Entrez Gene)
SOS2GeneProduct452897 (Entrez Gene)
SRFGeneProduct462709 (Entrez Gene)
STK3GeneProduct472829 (Entrez Gene)
STMN1GeneProduct456650 (Entrez Gene)
Sap1aGeneProduct
TAOK1GeneProduct454548 (Entrez Gene)
TAOK2GeneProduct454033 (Entrez Gene)
TGFB1GeneProduct456060 (Entrez Gene)
TGFB2GeneProduct457742 (Entrez Gene)
TGFB3GeneProduct453054 (Entrez Gene)
TGFBR1GeneProduct472992 (Entrez Gene)
TGFBR2GeneProduct460243 (Entrez Gene)
TMEM37GeneProduct459575 (Entrez Gene)
TNFGeneProduct744399 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
TRAF2GeneProduct
TRAF6GeneProduct451702 (Entrez Gene)
ZAKGeneProduct
cAMPMetaboliteHMDB00058 (HMDB)
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP880"
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