Oxidation by cytochrome P450 (Pan troglodytes)

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1Cytochrome P450 genesNADHCYP27C1CYP2G1PCYP3A7CYP7A1CYP2C19O2Fe2+CYP2J2CYB5ACYP4X1CYP2A7CYB5BCYP20A1CYP21A2Fe2+CYB5BCYP4Z1CYP4V2Fe3+SubstrateH2OCYP4F11CYB5ACYP4F22SubstrateA4ZZ70_PANTRCYP4B1activated O2CYP2C18CYP2B6CYP2C9CYB5R3CYP17A1CYP2A6SubstrateCYB5R2CYP51A1CYP11A1CYP11B1CYP2S1Fe3+CYP2W1Substrate-OHCYPCYP4F8Fe2+CYP39A1CYP2F1CYB5ACYP4A22CYP7B1CP2D6_PANTRCYB5R4CYP8B1Fe2+CYP27A1CYP2E1CYP2C8CYPB1NL93_PANTRCYPCYB5BCYPCYP51A1CYP2U1CYP26A1CYP4A11CYP4F2CYP27B1CYPSubstrateNADP+CYP46A1XR_025213.1CYP1A1NADPHQ9N256_PANTRNAD+B1NLA1_PANTRO2CYP2R1CYP19A1PORCYP1B1CYP26B1CYP26C1CYB5R1Fe3+CYP11B2CYP4F3CYP2A13Fe3+CYP24A1Substrate


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 78% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
118189view10:51, 25 May 2021EweitzModified title
107229view14:32, 17 September 2019MaintBotChEBI identifier normalization
88278view14:39, 1 August 2016FehrhartOntology Term : 'hepatocyte' added !
88277view14:39, 1 August 2016FehrhartOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88276view14:38, 1 August 2016FehrhartOntology Term : 'xenobiotics biodegradation pathway' added !
74170view14:52, 2 April 2014EgonwUpdated the PubChem-compound data source.
73519view23:32, 29 January 2014KhanspersModified title
71671view19:40, 17 October 2013MaintBotAutomated update of data sources
69262view18:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
58911view04:48, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41569view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
34297view22:04, 9 December 2009MaintBotAutomatic update of empty xrefs
33607view09:58, 1 December 2009MaintBotRemoved group label
30527view21:52, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A4ZZ70_PANTRGeneProductENSPTRG00000019458 (Ensembl Chimp)
B1NL93_PANTRGeneProductENSPTRG00000019460 (Ensembl Chimp)
B1NLA1_PANTRGeneProductENSPTRG00000019461 (Ensembl Chimp)
CP2D6_PANTRGeneProductENSPTRG00000034370 (Ensembl Chimp)
CYB5AGeneProductENSPTRG00000010111 (Ensembl Chimp)
CYB5BGeneProductENSPTRG00000008282 (Ensembl Chimp)
CYB5R1GeneProductENSPTRG00000001863 (Ensembl Chimp)
CYB5R2GeneProductENSPTRG00000003316 (Ensembl Chimp)
CYB5R3GeneProductENSPTRG00000014461 (Ensembl Chimp)
CYB5R4GeneProductENSPTRG00000018385 (Ensembl Chimp)
CYPGeneProduct
CYP11A1GeneProductENSPTRG00000007274 (Ensembl Chimp)
CYP11B1GeneProductENSPTRG00000020643 (Ensembl Chimp)
CYP11B2GeneProductENSPTRG00000020644 (Ensembl Chimp)
CYP17A1GeneProductENSPTRG00000002900 (Ensembl Chimp)
CYP19A1GeneProductENSPTRG00000007074 (Ensembl Chimp)
CYP1A1GeneProductENSPTRG00000007280 (Ensembl Chimp)
CYP1B1GeneProductENSPTRG00000011843 (Ensembl Chimp)
CYP20A1GeneProductENSPTRG00000012829 (Ensembl Chimp)
CYP21A2GeneProduct471972 (Entrez Gene)
CYP24A1GeneProductENSPTRG00000013640 (Ensembl Chimp)
CYP26A1GeneProductENSPTRG00000002763 (Ensembl Chimp)
CYP26B1GeneProductENSPTRG00000012051 (Ensembl Chimp)
CYP26C1GeneProductENSPTRG00000002762 (Ensembl Chimp)
CYP27A1GeneProductENSPTRG00000012928 (Ensembl Chimp)
CYP27B1GeneProductENSPTRG00000005149 (Ensembl Chimp)
CYP27C1GeneProductENSPTRG00000012425 (Ensembl Chimp)
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProductENSPTRG00000033800 (Ensembl Chimp)
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProductENSPTRG00000002779 (Ensembl Chimp)
CYP2C8GeneProductENSPTRG00000002781 (Ensembl Chimp)
CYP2C9GeneProductENSPTRG00000002780 (Ensembl Chimp)
CYP2E1GeneProductENSPTRG00000003099 (Ensembl Chimp)
CYP2F1GeneProductENSPTRG00000023634 (Ensembl Chimp)
CYP2G1PGeneProductENSPTRG00000011016 (Ensembl Chimp)
CYP2J2GeneProductENSPTRG00000000800 (Ensembl Chimp)
CYP2R1GeneProductENSPTRG00000003388 (Ensembl Chimp)
CYP2S1GeneProductENSPTRG00000011017 (Ensembl Chimp)
CYP2U1GeneProductENSPTRG00000016349 (Ensembl Chimp)
CYP2W1GeneProductENSPTRG00000022861 (Ensembl Chimp)
CYP39A1GeneProductENSPTRG00000018235 (Ensembl Chimp)
CYP3A7GeneProductENSPTRG00000019459 (Ensembl Chimp)
CYP46A1GeneProductENSPTRG00000006713 (Ensembl Chimp)
CYP4A11GeneProductENSPTRG00000000705 (Ensembl Chimp)
CYP4A22GeneProductENSPTRG00000000708 (Ensembl Chimp)
CYP4B1GeneProductENSPTRG00000000702 (Ensembl Chimp)
CYP4F11GeneProductENSPTRG00000010634 (Ensembl Chimp)
CYP4F22GeneProductENSPTRG00000010625 (Ensembl Chimp)
CYP4F2GeneProductENSPTRG00000010632 (Ensembl Chimp)
CYP4F3GeneProductENSPTRG00000010628 (Ensembl Chimp)
CYP4F8GeneProductENSPTRG00000010627 (Ensembl Chimp)
CYP4V2GeneProductENSPTRG00000016660 (Ensembl Chimp)
CYP4X1GeneProductENSPTRG00000000706 (Ensembl Chimp)
CYP4Z1GeneProductENSPTRG00000000707 (Ensembl Chimp)
CYP51A1GeneProductENSPTRG00000019391 (Ensembl Chimp)
CYP7A1GeneProductENSPTRG00000020275 (Ensembl Chimp)
CYP7B1GeneProductENSPTRG00000020297 (Ensembl Chimp)
CYP8B1GeneProductENSPTRG00000014804 (Ensembl Chimp)
Fe2+Metabolite29033 (ChEBI)
Fe3+Metabolite29034 (ChEBI)
H2OMetabolite
NAD+Metabolite15846 (ChEBI)
NADHMetabolite16908 (ChEBI)
NADP+Metabolite18009 (ChEBI)
NADPHMetabolite16474 (ChEBI)
O2Metabolite977 (PubChem)
PORGeneProductENSPTRG00000019313 (Ensembl Chimp)
Q9N256_PANTRGeneProductENSPTRG00000007281 (Ensembl Chimp)
SubstrateGeneProduct
Substrate-OHGeneProduct
XR_025213.1GeneProductENSPTRG00000010629 (Ensembl Chimp)
activated O2Metabolite

Annotated Interactions

No annotated interactions
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