Eicosanoid synthesis (Pan troglodytes)
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Thromboxane A3
Cell Membrane
Prostaglandin E2
15-Hydroperoxy Eicosatetraenoic Acid
6-Keto-Prostaglandin F2-alpha
12-Hydroperoxy Eicosatetraenoic Acid
TBXAS1
Prostaglandin I2
PTGS1
12-HETE
Leukotriene E4
ALOX15
Arachidonic acid
15-HETE
Leukotriene B4
ALOX5AP
ALOX5
5-HETE
Prostaglandin H2
DPEP1
LTC4S
GGT1
Peroxidase?
PTGDS
PTGES2
ALOX5
PGD2 11-ketoreduc
Leukotriene C4
PGE2 9-ketoreduc
ALOX15B
Thromboxane B2
ALOX5AP
Peroxidase?
PLA2G6
Prostaglandin D2
Leukotriene D4
Leukotriene A4
ALOX12
PLA2G2A
PTGES
PTGIS
PLA2G6
5-HPETE
Thromboxane A2
LTA4H
PNPLA8
PTGS2
Prostaglandin F2a
ALOX15
Peroxidase?
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP167(r21031)
with a 64% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117389
view
10:32, 21 May 2021
Eweitz
Modified title
106916
view
13:38, 17 September 2019
MaintBot
HMDB identifier normalization
89538
view
11:07, 16 September 2016
Mkutmon
ontology tag fix
89480
view
13:39, 15 September 2016
Mkutmon
remove space from ontology term id
78368
view
10:19, 7 January 2015
MaintBot
added missing graphIds
71678
view
19:41, 17 October 2013
MaintBot
Automated update of data sources
69276
view
18:39, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67187
view
10:18, 26 June 2013
Christine Chichester
Ontology Term : 'eicosanoid biosynthetic pathway' added !
62743
view
03:35, 2 May 2013
MaintBot
Updated UniProt data source
41585
view
02:00, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35482
view
12:16, 12 February 2010
Thomas
added literature
35478
view
12:14, 12 February 2010
Thomas
Modified description
34314
view
22:09, 9 December 2009
MaintBot
Automatic update of empty xrefs
33524
view
09:32, 1 December 2009
MaintBot
Removed group label
30423
view
21:16, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
12-HETE
Metabolite
15-HETE
Metabolite
5-HETE
Metabolite
5-HPETE
Metabolite
HMDB01193 (HMDB)
ALOX12
GeneProduct
455242 (Entrez Gene)
ALOX15
GeneProduct
748294 (Entrez Gene)
ALOX15B
GeneProduct
455104 (Entrez Gene)
ALOX5
GeneProduct
450428 (Entrez Gene)
ALOX5AP
GeneProduct
452520 (Entrez Gene)
Arachidonic acid
Metabolite
HMDB01043 (HMDB)
DPEP1
GeneProduct
GGT1
GeneProduct
470168 (Entrez Gene)
LTA4H
GeneProduct
452145 (Entrez Gene)
LTC4S
GeneProduct
739986 (Entrez Gene)
Leukotriene A4
Metabolite
HMDB01337 (HMDB)
Leukotriene B4
Metabolite
HMDB01085 (HMDB)
Leukotriene C4
Metabolite
HMDB01198 (HMDB)
Leukotriene D4
Metabolite
HMDB03080 (HMDB)
Leukotriene E4
Metabolite
HMDB02200 (HMDB)
PGD2 11-ketoreduc
GeneProduct
PGE2 9-ketoreduc
GeneProduct
PLA2G2A
GeneProduct
456587 (Entrez Gene)
PLA2G6
GeneProduct
PNPLA8
GeneProduct
472484 (Entrez Gene)
PTGDS
GeneProduct
749402 (Entrez Gene)
PTGES2
GeneProduct
464763 (Entrez Gene)
PTGES
GeneProduct
473071 (Entrez Gene)
PTGIS
GeneProduct
458323 (Entrez Gene)
PTGS1
GeneProduct
464713 (Entrez Gene)
PTGS2
GeneProduct
469616 (Entrez Gene)
Peroxidase?
GeneProduct
Prostaglandin D2
Metabolite
HMDB01403 (HMDB)
Prostaglandin F2a
Metabolite
HMDB01139 (HMDB)
Prostaglandin H2
Metabolite
HMDB01381 (HMDB)
Prostaglandin I2
Metabolite
HMDB01335 (HMDB)
TBXAS1
GeneProduct
463774 (Entrez Gene)
Thromboxane A2
Metabolite
HMDB01452 (HMDB)
Thromboxane B2
Metabolite
HMDB03252 (HMDB)
Annotated Interactions
No annotated interactions
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Discussion
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