Vulval development (Caenorhabditis elegans)

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1Uterine patterning:The anchor cell (AC) induces the six pi cells to generatethe utse cell and uv1 cells. The AC ultimately fuses with the utse cell, the uv1 cells attach to the vulF cells.Pn.pPn.pAnchor cell3°Vulval precursorpatterningP5.pP6.p3°Pn.pP7.pPn.p2°P4.pGeneration of the adult cells:Unique patterns of gene expression are established among 22 nuclei to generate distinct cell biology in cells of seven types vulA, vulB1, vulB2, vulC, VulD, vulE, and vulF, which will go on to make the adult vulva.Pn.pProliferationL3 moltWNT PathwayVulval precursor patterning:A signal from the gonad and signaling among the VPCs specifies three VPCs to generate vulval cells. Two types of vulval lineages, 1° and 2°, generate distinct sets of vulval cell progeny. Uninduced VPCs generate a 3° lineage, which make cells that fuse with the epidermis hyp7 cell. The VPCs adopt their fates in a precise spatial pattern of 3°-3°-2°-1°-2°-3°.Pn.pL3Fusion with hyp7Pn.pAnchor cellMorphogenesisof the vulvaAnchor cell invasionL2Pn.pPn.pL1Pn.pP8.pAnchor cell invasion: The anchor cell extends a process to the center of the vulF cells and forms a hole in the epidermis.1°2°Generation of the anchor cell:Two somatic gonadal cells are specified to become the anchor cell through an AC/UV decision.P3.pMorphogenesis of the vulva:The seven types of vulval cells invaginate, and sequentially form seven distinct toroids, connects to the uterus, and everts as the hermaphrodite molts to adulthood. LET-23/LET-60signalingGeneration of VPCs:Six vulval precursor cells (VPCs) are specified among the 11 Pn.p cells.Generation of VPCs3°Generation ofthe adult cellsPn.pResponsiveness to LIN-3Pn.pLIN-39LIN-39LIN-39EFF-1MAB-5LIN-39LIN-39MAB-5MAB-5LIN-39LIN-39LIN-39


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Vulval development

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Bibliography

  1. Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia
  2. Ihara S, Hagedorn EJ, Morrissey MA, Chi Q, Motegi F, Kramer JM, Sherwood DR; ''Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans.''; Nat Cell Biol, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135405view17:35, 3 September 2024EgonwConverted to use Ensembl identifiers
118334view13:11, 27 May 2021RaatsSfixed unconnected lines
78456view10:27, 7 January 2015MaintBotadded missing graphIds
73764view00:13, 22 February 2014MaintBotUpdating to 2013a GPML Schema
73762view00:11, 22 February 2014MaintBotupdating schema
57395view01:13, 27 January 2013Kyookadded reference #2
57394view01:06, 27 January 2013Kyookcosmetic fixes
49038view19:01, 3 July 2012KyookOntology Term : 'Ras mediated signaling pathway' added !
49037view19:00, 3 July 2012KyookOntology Term : 'EGF/neuregulin signaling pathway' added !
49036view19:00, 3 July 2012KyookOntology Term : 'Wnt signaling pathway' added !
49035view19:00, 3 July 2012KyookOntology Term : 'Notch signaling pathway' added !
49031view18:55, 3 July 2012KyookPeriodical save, work in progress
49024view18:43, 3 July 2012KyookPeriodical save, work in progress
49000view00:10, 3 July 2012KyookPeriodical save, work in progress
48999view23:46, 2 July 2012KyookBM gap
48998view23:44, 2 July 2012KyookPeriodical save, work in progress
48997view23:34, 2 July 2012KyookPeriodical save, work in progress
48996view23:24, 2 July 2012KyookPeriodical save, work in progress
48995view23:14, 2 July 2012KyookPeriodical save, work in progress
48994view23:03, 2 July 2012KyookPeriodical save, work in progress
48990view22:53, 2 July 2012KyookPeriodical save, work in progress
48984view22:43, 2 July 2012KyookPeriodical save, work in progress
48983view22:36, 2 July 2012Kyookanchor cell shape
48982view22:33, 2 July 2012KyookPeriodical save, work in progress
48981view22:15, 2 July 2012Kyookanchor cell invasion
48980view22:13, 2 July 2012KyookPeriodical save, work in progress
48979view22:03, 2 July 2012KyookPeriodical save, work in progress
48978view21:50, 2 July 2012KyookPeriodical save, work in progress
48977view21:43, 2 July 2012Kyookdashed lineage lines
48976view21:21, 2 July 2012KyookPeriodical save, work in progress
48975view21:00, 2 July 2012KyookPeriodical save, work in progress
48928view21:07, 29 June 2012Kyookupdated Vulval Development
48927view20:53, 29 June 2012KyookPeriodical save, work in progress
48926view20:43, 29 June 2012KyookPeriodical save, work in progress
48922view20:23, 29 June 2012KyookPeriodical save, work in progress
48921view20:13, 29 June 2012KyookPeriodical save, work in progress
48920view19:32, 29 June 2012KyookPeriodical save, work in progress
48919view19:16, 29 June 2012Kyookupdate to Vulval development
40648view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
34636view19:03, 7 January 2010KhanspersModified categories
34604view23:14, 23 December 2009KyookPeriodical save, work in progress
34603view22:26, 23 December 2009KyookPeriodical save, work in progress
34602view22:10, 23 December 2009KyookNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
EFF-1GeneProductC26D10.5 (WormBase)
LIN-39GeneProductC07H6.7 (Ensembl C. elegans)
LIN-39GeneProductC07H6.7 (WormBase)
MAB-5GeneProductC08C3.3 (WormBase)

Annotated Interactions

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