Cell division: first embryonic mitosis (Caenorhabditis elegans)

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13GO:0005813centrosomeproteinsGO:0005694chromosomeGO:0000776kinetochoreMitotic chromosomeproteinsKinetochore proteinsGO:0005634nucleusCentrosome proteinsGO:0000793condensed chromosome proteinsGO:0000793condensed chromosomeGO:0018985pronuclear envelopesynthesisGO:0051233spindle midzoneGO:0000777condensed chromosome kinetochore proteinGO:0007084mitotic nuclear envelopereassemblyCytokinesiscytoskeletal proteinsGO:0032154cleavage furrowGO:0007077mitotic nuclear envelopedisassemblyGO:0035047centrosomal and pronuclear rotationGO:0005635nuclear envelopeproteinsGO:0035046Pronuclear migrationGO:0000778condensed nuclear chromosome kinetochoreGO:0030892mitotic cohesin complex proteinsGO:0051297centrosome organizationGO:0005814centriolePronuclei formationGO:0040038Polar body extrusion after meiotic divisionNuclear envelopeproteinsGO:0008278cohesin complexproteinsPLK-1IMA-2MLC-4UNC-37KBP-2BUB-1DNC-2Y47D3A.29DYRB-1TAC-1TBB-1NUD-1ANI-1AIR-121ur-13952CeMCAKMEL-11BEN-1LIS-1PFD-5CUL-3CYK-1HCP-6KNL-2T13E8.3TBA-2MEL-2821ur-15150DLI-1UNC-60APLL-1RBX-1CeLamin/LMN-1TAG-170ZEN-4PUF-3HIM-1ZEN-4KLE-2GPC-2CYK-4TAC-1SPD-5SAS-4KNL-3NDC-80ICP-1/CeINCENPDNC-1DNC-4Spc25/KBP-3PFN-1DNC-1LET-502HCP-2MFDF-1PFD-2T26A5.8Y71F9AL.14SPD-5DYCI-1BIR-1TBA-4g-tubulin/TBG-1KNL-1LET-99ZYG-9SPD-2TIM-1CeCENP-ATBA-1GPB-1CeGrip-2/GIP-2SAS-6BIR-1Ce-MAN1/LEM-2MIS-12ARP-1KBP-5CYK-1CAP-GMDF-2AIR-2CLASPLRG-1ZYG-9PAR-5DHC-1ICP-1/CeINCEPnuf-2/HIM-10CAP-2RHO-1SMC-4SCC-3LET-92NMY-2DLC-1NUD-1SCC-1UNC-83LIS-1BIR-1LET-21/Ect-2MIX-1ZYG-12T16G12.1CeCENP-CKBP-1SPD-2UNC-61HCP-1SAS-5Ce-emerin/EMR-1SMC-3SPD-5ANI-1ANC-1SPD-1UNC-84AIR-2MBK-2DNC-2ZYG-1ZYG-12PFD-3AIR-1TBB-2SAN-1Ce-BAF-1BUB-3LET-754KBP-1Matefin/SUN-1CeGrip-1/GIP-1CZW-1KLP-19CSC-1T13E8.2Y19D2B.1F54B3.3ROD-1CYK-4UNC-59PLK-22, 37133743713, 23, 4013, 2813, 3613, 2313133711131324, 29, 3724371313133711378, 13613, 36131337371, 21, 30, 371313, 2812, 13, 293713375, 1317241313, 3913133731313371313, 22, 26, 27, 3513, 39913, 1413131324, 3713, 392013, 40371313133719, 371337371313131313113713, 181313, 3113133713, 2810, 371313, 393713251313371615131313134, 34, 371313, 362, 373721337137, 13, 3213371313, 3313, 23, 385, 13, 221311, 24, 37132131313373730374373713, 36133724, 375, 13


Description

"Prior to fertilization, C. elegans oocytes are arrested in meiotic prophase with nuclei containing two copies of the diploid genome packaged into recombined bivalent chromosomes. The two rounds of meiotic chromosome segregation that generate the haploid oocyte pronucleus are completed in the zygote after the oocytes are fertilized. During each meiotic division, chromosome segregation is accomplished by a small acentriolar meiotic spindle that forms in the embryo anterior. During anaphase of meiosis I and again in meiosis II, the meiotic spindle associates with the cortex in an end-on fashion, and a highly asymmetric cytokinesis-like event extrudes a polar body (Figure 2; Albertson and Thomson, 1993; Clark-Maguire and Mains, 1994; Yang et al., 2003). In addition to the haploid pronucleus, the sperm brings a pair of centrioles into the oocyte, which lacks centrioles due to their degradation during oogenesis. As meiosis completes, the haploid oocyte and sperm-derived pronuclei, located at opposite ends of the embryo increase in size, becoming visible by DIC microscopy. After entering the oocyte, the sperm-derived centriole pair recruits pericentriolar material and acquires the ability to nucleate microtubules (O'Connell, 2000; Pelletier et al., 2004). Subsequently, the two sperm-derived centrioles separate, forming two centrosomes positioned on either side of the paternal pronucleus. Coincident with chromosome condensation during mitotic prophase, the pronuclei migrate towards each other. After the pronuclei meet, the nuclear-centrosome complex moves to the center of the embryo and rotates to align with the long axis of the embryo (Albertson, 1984; Hyman and White, 1987). The miotitc spindle begins to move towards the embryo posterior during metaphase (Labbe et al., 2004; Oegema et al., 2001), and asymmetric elongation during anaphase contributes to its posterior displacement (Albertson, 1984; Grill et al., 2001). Since the cleavage furrow bisects the mitotic spindle, this displacement results in an asymmetric first cleavage (For more on the mechanisms that generate this asymmetry see Asymmetric cell division and axis formation in the embryo). " From "Cell division" by Karen Oegema, WormBook

Comments

 
"Prior to fertilization, C. elegans oocytes are arrested in meiotic prophase with nuclei containing two copies of the diploid genome packaged into recombined bivalent chromosomes. The two rounds of meiotic chromosome segregation that generate the haploid oocyte pronucleus are completed in the zygote after the oocytes are fertilized. During each meiotic division, chromosome segregation is accomplished by a small acentriolar meiotic spindle that forms in the embryo anterior. During anaphase of meiosis I and again in meiosis II, the meiotic spindle associates with the cortex in an end-on fashion, and a highly asymmetric cytokinesis-like event extrudes a polar body (Figure 2; Albertson and Thomson, 1993; Clark-Maguire and Mains, 1994; Yang et al., 2003). In addition to the haploid pronucleus, the sperm brings a pair of centrioles into the oocyte, which lacks centrioles due to their degradation during oogenesis. As meiosis completes, the haploid oocyte and sperm-derived pronuclei, located at opposite ends of the embryo increase in size, becoming visible by DIC microscopy. After entering the oocyte, the sperm-derived centriole pair recruits pericentriolar material and acquires the ability to nucleate microtubules (O'Connell, 2000; Pelletier et al., 2004). Subsequently, the two sperm-derived centrioles separate, forming two centrosomes positioned on either side of the paternal pronucleus. Coincident with chromosome condensation during mitotic prophase, the pronuclei migrate towards each other. After the pronuclei meet, the nuclear-centrosome complex moves to the center of the embryo and rotates to align with the long axis of the embryo (Albertson, 1984; Hyman and White, 1987). The miotitc spindle begins to move towards the embryo posterior during metaphase (Labbe et al., 2004; Oegema et al., 2001), and asymmetric elongation during anaphase contributes to its posterior displacement (Albertson, 1984; Grill et al., 2001). Since the cleavage furrow bisects the mitotic spindle, this displacement results in an asymmetric first cleavage (For more on the mechanisms that generate this asymmetry see Asymmetric cell division and axis formation in the embryo). "
 
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Bibliography

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History

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CompareRevisionActionTimeUserComment
135389view12:10, 3 September 2024EgonwUpdated a WormBase id to Ensembl
135363view04:57, 2 September 2024EgonwConverted to use Ensembl identifiers
118330view12:58, 27 May 2021RaatsSfixed unconnected lines and too small labels
117055view14:20, 16 May 2021EweitzModified title
84464view19:09, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
78455view10:27, 7 January 2015MaintBotadded missing graphIds
75501view21:27, 3 June 2014KyookOntology Term : 'pathway pertinent to DNA replication, cell cycle, DNA repair and maintenance of genomic integrity, RNA and protein biosynthesis' added !
75500view21:26, 3 June 2014KyookOntology Term : 'animal cell' added !
74473view04:17, 25 April 2014EgonwFixed a PubMed ID.
72144view10:05, 25 October 2013Mkutmonadded datasource for NUD-1
70080view09:54, 12 July 2013Mkutmonusing graphical line elements instead of interaction lines
50937view23:15, 24 August 2012KyookOntology Term : 'zygote' added !
40640view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
34963view22:50, 8 February 2010KhanspersFixed xrefs
34962view22:44, 8 February 2010KhanspersCleaned up comments
34961view22:42, 8 February 2010KhanspersReverted to version '23:44, 23 December 2009' by Khanspers
34960view22:41, 8 February 2010KhanspersCleaned up comments
34606view23:44, 23 December 2009KyookModified description
34605view23:38, 23 December 2009Kyookremoved extra objects, cleaned up the page a bit
33371view14:35, 30 November 2009MaintBotRemoved group label
33193view18:10, 5 November 2009KhanspersModified categories
32938view21:19, 22 September 2009KyookNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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21ur-15150GeneProductK10D11.8
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ARP-1GeneProductY53F4B.22GO:0002009 WBPaper00006395

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ICP-1/CeINCEPGeneProductY39G10AR.13 (WormBase)
IMA-2GeneProductF26B1.3 (WormBase) GO:0007084
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Matefin/SUN-1GeneProductF57B1.2 (WormBase)
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NMY-2GeneProductF20G4.3 (WormBase)
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PAR-5GeneProductM117.2 (WormBase)
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PFD-3GeneProductT06G6.9 (WormBase)
PFD-5GeneProductR151.9 (WormBase)
PFN-1GeneProductY18D10A.20 (WormBase)
PLK-1GeneProductC14B9.4 (WormBase) GO:0000003

GO:0000003 GO:0007077 GO:0000910 GO:0009792 GO:0008340 GO:0051301 GO:0040035 GO:0040038 GO:0051726 GO:0002119

GO:0045132
PLK-2GeneProductC14B9.4 (WormBase) GO:0000003

GO:0000003 GO:0007077 GO:0000910 GO:0009792 GO:0008340 GO:0051301 GO:0040035 GO:0040038 GO:0051726 GO:0002119

GO:0045132
PLL-1GeneProductK10F12.3 (WormBase)
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SAS-6GeneProductY45F10D.9 (WormBase)
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SPD-1GeneProductY34D9A.4 (WormBase)
SPD-2GeneProductF32H2.3 (WormBase)
SPD-5GeneProductF56A3.4 (WormBase)
Spc25/KBP-3GeneProductF26H11.1 (WormBase)
T13E8.2GeneProductT13E8.2 (WormBase)
T13E8.3GeneProductT13E8.3 (WormBase)
T16G12.1GeneProductT16G12.1 (WormBase)
T26A5.8GeneProductT26A5.8 (WormBase)
TAC-1GeneProductY54E2A.3 (WormBase)
TAG-170GeneProductC05D11.3 (WormBase)
TBA-1GeneProductF26E4.8 (WormBase)
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TBA-4GeneProductF44F4.11 (WormBase)
TBB-1GeneProductK01G5.7 (WormBase)
TBB-2GeneProductC36E8.5 (WormBase)
TIM-1GeneProductY75B8A.22 (WormBase)
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ZEN-4GeneProductM03D4.1 (WormBase)
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ZYG-9GeneProductF22B5.7 (WormBase)
g-tubulin/TBG-1GeneProductF58A4.8 (WormBase)
nuf-2/HIM-10GeneProductR12B2.4 (WormBase)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1411"
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