ACE inhibitor pathway (Danio rerio)

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Cell MembraneHOMOLOGY MAPPrenACEAldosteroneACE Inhibitorzgc:103569BDKRB2Angiotensin IIzgc:113016agtACEAGTR1NOS3zgc:103569Angiotensin I


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

GenMAPP notes 
https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.
GenMAPP remarks 
Adapted from PharmGKB (right click for info)

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Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116845view10:42, 14 May 2021EweitzModified title
106087view11:59, 16 August 2019MaintBotHMDB identifier normalization
85436view09:40, 15 May 2016Egonw
85433view09:37, 15 May 2016EgonwQuick edit to datanode annotation or property
77438view20:25, 8 September 2014MaintBotremoved old homology label
77432view12:13, 8 September 2014Mkutmonupdated some gene labels
71512view19:21, 17 October 2013MaintBotAutomated update of data sources
68641view04:55, 6 July 2013MaintBotUpdated to 2013 gpml schema
67019view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57055view15:54, 20 January 2013EgonwUsed "PubChem-compound"
48313view04:38, 18 May 2012KhanspersUpdating PubChem xrefs
46426view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40809view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35054view10:34, 11 February 2010Thomasconnected lines
35053view10:32, 11 February 2010Thomasfixed annotations, added literature reference
35045view09:35, 11 February 2010Thomas
35037view09:28, 11 February 2010ThomasModified description
21664view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP468]]: Moved to stable identifier
12064view08:46, 15 May 2008MaintBotAdded to category $category
12062view08:46, 15 May 2008C.F.ThornUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorGeneProduct
ACEGeneProduct
AGTR1GeneProduct
AldosteroneGeneProduct
Angiotensin IGeneProduct
Angiotensin IIGeneProduct
BDKRB2GeneProduct
NOS3GeneProduct
agtGeneProduct322485 (Entrez Gene)
renGeneProduct405786 (Entrez Gene)
zgc:103569GeneProduct449808 (Entrez Gene)
zgc:113016GeneProduct503772 (Entrez Gene)

Annotated Interactions

No annotated interactions
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