ACE inhibitor pathway (Canis familiaris)

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1Cell MembraneAGTR2BradykininACEKNG1AGTRENACE InhibitorAGTR1ACEBDKRB2Angiotensin IIAldosteroneAngiotensin INOS3


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

GenMAPP notes 
https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.
GenMAPP remarks 
Adapted from PharmGKB (right click for info)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 88% conversion rate.

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Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117438view10:51, 21 May 2021EweitzModified title
106052view11:57, 16 August 2019MaintBotHMDB identifier normalization
85435view09:40, 15 May 2016Egonw
85432view09:37, 15 May 2016EgonwQuick edit to datanode annotation or property
71478view19:18, 17 October 2013MaintBotAutomated update of data sources
68571view22:57, 5 July 2013MaintBotUpdated to 2013 gpml schema
67017view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57077view20:14, 20 January 2013EgonwUsed "PubChem-compound"
40729view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35049view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35041view09:29, 11 February 2010ThomasModified description
34008view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
31769view12:08, 14 August 2009MaintBotFixed group labels
30720view22:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorMetabolite
ACEGeneProduct610668 (Entrez Gene)
AGTGeneProduct403783 (Entrez Gene)
AGTR1GeneProduct403836 (Entrez Gene)
AGTR2GeneProduct403835 (Entrez Gene)
AldosteroneMetaboliteC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB2GeneProduct403658 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
KNG1GeneProduct478666 (Entrez Gene)
NOS3GeneProduct403784 (Entrez Gene)
RENGeneProduct403838 (Entrez Gene)

Annotated Interactions

No annotated interactions
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