ACE inhibitor pathway (Mus musculus)

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Cell MembraneBdkrb2Angiotensin IIAgtr1Ren1AceAngiotensin INos3BradykininAceAgtKng1ACE InhibitorAldosteroneAgtr2


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

GenMAPP notes 
https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.
GenMAPP remarks 
Adapted from PharmGKB (right click for info)

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Ontology Terms

 

Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116828view10:28, 14 May 2021EweitzModified title
110700view14:09, 28 May 2020EgonwAdded missing @Type annotation
106888view13:36, 17 September 2019MaintBotHMDB identifier normalization
97382view17:28, 13 May 2018EgonwAldosterone is a metabolite
85437view09:40, 15 May 2016Egonw
85434view09:38, 15 May 2016EgonwQuick edit to datanode annotation or property
71314view17:15, 17 October 2013MaintBotAutomated update of data sources
70842view23:31, 11 September 2013Khanspersadded Wikipedia xref to ACE inhibitor
67018view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
60841view11:49, 29 March 2013EgonwFixed a metabolite which was annotated as GeneProduct.
48253view21:39, 17 May 2012KhanspersUpdating PubChem xrefs
41266view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35050view09:40, 11 February 2010Thomasadded literature reference
35043view09:34, 11 February 2010Thomasremoved genmapp notes (invalid link)
35042view09:32, 11 February 2010Thomasfixed metabolite annotations
35035view09:27, 11 February 2010ThomasModified description
33667view21:59, 2 December 2009KhanspersAdded connectors
21516view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP396]]: Moved to stable identifier
11885view18:20, 8 May 2008KhanspersChanged contact info
7874view13:46, 7 January 2008MaintBot[[Pathway:Mouse:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Mus musculus:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7562view16:00, 18 December 2007MaintBotfixed category names
7450view12:42, 4 November 2007MaintBotAdded categories to GPML
6409view22:18, 22 May 2007C.F.Thorngpml file for [[Mouse:ACE-Inhibitor_pathway_PharmGKB]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorGeneProduct
AceGeneProduct11421 (Entrez Gene)
AgtGeneProduct11606 (Entrez Gene)
Agtr1GeneProduct11607 (Entrez Gene)
Agtr2GeneProduct11609 (Entrez Gene)
AldosteroneGeneProductC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
Bdkrb2GeneProduct12062 (Entrez Gene)
BradykininGeneProductHMDB04246 (HMDB)
Kng1GeneProduct16644 (Entrez Gene)
Nos3GeneProduct18127 (Entrez Gene)
Ren1GeneProduct19701 (Entrez Gene)

Annotated Interactions

No annotated interactions
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