ACE inhibitor pathway (Rattus norvegicus)

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Cell MembraneACE InhibitorAngiotensin IIAceAldosteroneAngiotensin INos3AgtAgtr2Kng1AceAgtr1BradykininRen1Bdkrb2


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

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Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116935view10:00, 16 May 2021EweitzModified title
107000view13:45, 17 September 2019MaintBotHMDB identifier normalization
81317view19:16, 18 August 2015MaintBotremoved fill color for arc
70957view22:09, 17 September 2013MaintBotadded aldosterone xref
67021view09:55, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
63280view13:38, 9 May 2013EgonwForgot to set the database :(
63279view13:35, 9 May 2013EgonwAdded the ChEBI identifier for angiotensin-converting enzyme inhibitors
48278view23:28, 17 May 2012KhanspersUpdating PubChem xrefs
41786view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
35051view09:46, 11 February 2010Thomasannotated metabolites, connected lines, added literature
35044view09:35, 11 February 2010Thomasremoved genmapp notes (invalid link)
35036view09:28, 11 February 2010ThomasModified description
21852view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP557]]: Moved to stable identifier
11889view18:22, 8 May 2008KhanspersChanged contact info
7876view13:46, 7 January 2008MaintBot[[Pathway:Rat:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Rattus norvegicus:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7563view16:00, 18 December 2007MaintBotfixed category names
7451view12:42, 4 November 2007MaintBotAdded categories to GPML
6513view22:19, 22 May 2007C.F.Thorngpml file for [[Rat:ACE-Inhibitor_pathway_PharmGKB]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorGeneProduct
AceGeneProduct24310 (Entrez Gene)
AgtGeneProduct24179 (Entrez Gene)
Agtr1GeneProduct81638 (Entrez Gene)
Agtr2GeneProduct24182 (Entrez Gene)
AldosteroneGeneProduct
Angiotensin IGeneProduct
Angiotensin IIGeneProduct
Bdkrb2GeneProduct25245 (Entrez Gene)
BradykininGeneProduct
Kng1GeneProduct24903 (Entrez Gene)
Nos3GeneProduct24600 (Entrez Gene)
Ren1GeneProduct24715 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP557"
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