ACE inhibitor pathway (Pan troglodytes)

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1Cell MembraneKNG1AldosteroneAGTNOS3ACEACEAngiotensin IIBDKRB2AGTR2ACE InhibitorAngiotensin IRENBradykininAGTR1


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117381view10:31, 21 May 2021EweitzModified title
106934view13:40, 17 September 2019MaintBotHMDB identifier normalization
85431view09:36, 15 May 2016EgonwQuick edit to datanode annotation or property
71689view19:42, 17 October 2013MaintBotAutomated update of data sources
70570view14:52, 13 August 2013MetalmephistoFixed Angiotensin ID
69295view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67023view09:55, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57064view16:54, 20 January 2013EgonwUsed "PubChem-compound"
41605view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
35047view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35039view09:29, 11 February 2010ThomasModified description
34334view22:16, 9 December 2009MaintBotAutomatic update of empty xrefs
33572view09:47, 1 December 2009MaintBotRemoved group label
30484view21:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorMetabolite
ACEGeneProduct449567 (Entrez Gene)
AGTGeneProduct450104 (Entrez Gene)
AGTR1GeneProduct460762 (Entrez Gene)
AGTR2GeneProduct742608 (Entrez Gene)
AldosteroneMetaboliteC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB2GeneProduct467547 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
KNG1GeneProduct460916 (Entrez Gene)
NOS3GeneProduct463893 (Entrez Gene)
RENGeneProduct469651 (Entrez Gene)

Annotated Interactions

No annotated interactions
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