ACE inhibitor pathway (Danio rerio)

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1HOMOLOGY MAPPCell MembraneAngiotensin IAldosteronebdkrb2agtr2ace2ace2kng1renBradykininNOS3agtr1Angiotensin IIACE Inhibitoragt


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

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Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116845view10:42, 14 May 2021EweitzModified title
106087view11:59, 16 August 2019MaintBotHMDB identifier normalization
85436view09:40, 15 May 2016Egonw
85433view09:37, 15 May 2016EgonwQuick edit to datanode annotation or property
77438view20:25, 8 September 2014MaintBotremoved old homology label
77432view12:13, 8 September 2014Mkutmonupdated some gene labels
71512view19:21, 17 October 2013MaintBotAutomated update of data sources
68641view04:55, 6 July 2013MaintBotUpdated to 2013 gpml schema
67019view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57055view15:54, 20 January 2013EgonwUsed "PubChem-compound"
48313view04:38, 18 May 2012KhanspersUpdating PubChem xrefs
46426view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40809view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35054view10:34, 11 February 2010Thomasconnected lines
35053view10:32, 11 February 2010Thomasfixed annotations, added literature reference
35045view09:35, 11 February 2010Thomas
35037view09:28, 11 February 2010ThomasModified description
21664view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP468]]: Moved to stable identifier
12064view08:46, 15 May 2008MaintBotAdded to category $category
12062view08:46, 15 May 2008C.F.ThornUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE InhibitorMetabolite
AldosteroneMetaboliteC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BradykininMetaboliteHMDB04246 (HMDB)
NOS3GeneProduct
ace2GeneProduct492331 (Entrez Gene)
agtGeneProduct322485 (Entrez Gene)
agtr1GeneProduct561935 (Entrez Gene)
agtr2GeneProduct503772 (Entrez Gene)
bdkrb2GeneProduct368199 (Entrez Gene)
kng1GeneProduct449808 (Entrez Gene)
renGeneProduct405786 (Entrez Gene)

Annotated Interactions

No annotated interactions

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