EPO receptor signaling (Homo sapiens)
From WikiPathways
Description
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia
This pathway is based on ScienceSlides.
Quality Tags
Ontology Terms
Bibliography
- Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia
- Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
CD45 | GeneProduct | 5788 (Entrez Gene) | |
CISH | GeneProduct | 1154 (Entrez Gene) | |
EPO | GeneProduct | 2056 (Entrez Gene) | |
EPOR | GeneProduct | 2057 (Entrez Gene) | |
ERK1 | GeneProduct | 5595 (Entrez Gene) | |
ERK2 | GeneProduct | 5594 (Entrez Gene) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
IRS1 | GeneProduct | 3667 (Entrez Gene) | |
IRS2 | GeneProduct | 8660 (Entrez Gene) | |
JAK2 | GeneProduct | 3717 (Entrez Gene) | |
MEK1 | GeneProduct | 5604 (Entrez Gene) | |
MEK2 | GeneProduct | 5605 (Entrez Gene) | |
PDK1 | GeneProduct | 5163 (Entrez Gene) | |
PI3K | GeneProduct | 5294 (Entrez Gene) | |
PKB | GeneProduct | 207 (Entrez Gene) | |
PTP | GeneProduct | 10076 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RAS | GeneProduct | 5921 (Entrez Gene) | |
RASA1 | GeneProduct | 5921 (Entrez Gene) | |
SHC1 | GeneProduct | 6464 (Entrez Gene) | |
SOCS1 | GeneProduct | 8651 (Entrez Gene) | |
SOS1 | GeneProduct | 6654 (Entrez Gene) | |
SRC | GeneProduct | 6714 (Entrez Gene) | |
STAT1 | GeneProduct | 6772 (Entrez Gene) | |
STAT3 | GeneProduct | 6774 (Entrez Gene) | |
STAT5A | GeneProduct | 6776 (Entrez Gene) | |
STAT5B | GeneProduct | 6777 (Entrez Gene) |
Annotated Interactions
No annotated interactions