Wnt signaling pathway (Bos taurus)

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1P-CateninTranscriptional ActivationApoptosisCytoskeletonRecruitment to UnknownUbiquitin TaggedB - Catenin26S Proteasome DegredationBNucleusPhosphorylatedFrizzled LigandsUbiquitin Conjugating EnzymePRKCAPRKCEWNT5AFZD8WNT2CCND2FZD2RHOARAC1FZD10FZD1WNT16WNT10BFRAT1WNT5BWNT7BCSNK1EJUNMAPK9FOSL1FZD9FZD5SFRP4LDLRWNT3GSK3BAXIN1WNT16PRKCHWNT10AFZD7PLAUFZD6PRKCGPAFAH1B1WNT2BPRKCQPPP2R5CPRKCIWNT1DVL2WNT3AWNT7APRKCDPRKCZMYCFBXW2PRKD1WNT11TCF-1/LEFCTNNB1WNT4CCND1MAPK10APCLOC539203PRKCBCCND3FZD3WNT6DVL1PPP2R5E


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 90% conversion rate.

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Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117633view11:46, 21 May 2021EweitzModified title
115733view09:41, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
115238view08:22, 7 February 2021EgonwMade two pathways clickable
80843view15:28, 30 June 2015Mkutmonhomology conversion
71410view19:01, 17 October 2013MaintBotAutomated update of data sources
67747view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
63351view22:22, 9 May 2013MaintBotUpdated to 2013 gpml schema
40525view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35128view13:39, 11 February 2010Thomasconnected line
35120view13:24, 11 February 2010Thomasadded literature
35110view13:17, 11 February 2010ThomasModified description
33767view00:05, 9 December 2009MaintBotAutomatic update of empty xrefs
32493view12:46, 17 August 2009MaintBotFixed text labels
32186view12:33, 15 August 2009MaintBotFixed text labels
31657view11:38, 14 August 2009MaintBotFixed group labels
31191view19:30, 13 August 2009MaintBotFixed text labels
30585view22:10, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct533233 (Entrez Gene)
AXIN1GeneProduct504357 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CCND2GeneProduct615414 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CSNK1EGeneProduct768234 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
DVL1GeneProduct523325 (Entrez Gene)
DVL2GeneProduct614312 (Entrez Gene)
FBXW2GeneProduct767863 (Entrez Gene)
FOSL1GeneProduct531389 (Entrez Gene)
FRAT1GeneProduct505664 (Entrez Gene)
FZD10GeneProduct515323 (Entrez Gene)
FZD1GeneProduct445417 (Entrez Gene)
FZD2GeneProduct538507 (Entrez Gene)
FZD3GeneProduct445419 (Entrez Gene)
FZD5GeneProduct538536 (Entrez Gene)
FZD6GeneProduct445418 (Entrez Gene)
FZD7GeneProduct524255 (Entrez Gene)
FZD8GeneProduct616913 (Entrez Gene)
FZD9GeneProduct521364 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene) MOUSE:KG38 MOUSE
JUNGeneProduct280831 (Entrez Gene)
LDLRGeneProduct281276 (Entrez Gene)
LOC539203GeneProduct539203 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
PAFAH1B1GeneProduct282513 (Entrez Gene)
PLAUGeneProduct281408 (Entrez Gene)
PPP2R5CGeneProduct505757 (Entrez Gene)
PPP2R5EGeneProduct533617 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PRKD1GeneProduct533270 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
SFRP4GeneProduct518004 (Entrez Gene)
TCF-1/LEFGeneProduct
WNT10AGeneProduct537330 (Entrez Gene)
WNT10BGeneProduct539337 (Entrez Gene)
WNT11GeneProduct613288 (Entrez Gene)
WNT1GeneProduct540662 (Entrez Gene)
WNT16GeneProduct538627 (Entrez Gene)
WNT2GeneProduct493729 (Entrez Gene)
WNT2BGeneProduct445420 (Entrez Gene)
WNT3GeneProduct540753 (Entrez Gene)
WNT3AGeneProduct522467 (Entrez Gene)
WNT4GeneProduct
WNT5AGeneProduct530005 (Entrez Gene)
WNT5BGeneProduct508008 (Entrez Gene)
WNT6GeneProduct505075 (Entrez Gene)
WNT7AGeneProduct533782 (Entrez Gene)
WNT7BGeneProduct525135 (Entrez Gene)

Annotated Interactions

No annotated interactions
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