Biogenic amine synthesis (Canis familiaris)
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Synthesis pathways for biogenic amines
follow solid arrows through enzymatic steps,
while degradation steps follow dashed arrows.
Acetylserotonin
CHAT
Serotonin
MAOA
Melatonin
Histamine
GAD2
Phenylalanine
COMT
Tyrosine
Epinephrine
Histidine
DDC
HDC
ASMT
GAD1
Tryptophan
TPH1
MAOA
DBH
L-DOPA
5-hydroxy-tryptophan
Norepinephrine
Glutamate
Choline
DDC
Acetylcholine
TH
ACHE
AANAT
PAH
PNMT
Dopamine
GABA
DDC
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP550(r21838)
with a 50% conversion rate.
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Bibliography
Purves, Dale, Augustine, George J., Fitzpatrick, David, Katz, Lawrence C., LaMantia, Anthony-Samuel, McNamara, James O., Williams, S. Mark.; ''Neuroscience''; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=neurosci&part=A405, 2001
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Action
Time
User
Comment
117439
view
10:51, 21 May 2021
Eweitz
Modified title
106042
view
11:56, 16 August 2019
MaintBot
HMDB identifier normalization
89462
view
13:13, 15 September 2016
Mkutmon
remove space in ontology term id
71493
view
19:19, 17 October 2013
MaintBot
Automated update of data sources
68606
view
23:31, 5 July 2013
MaintBot
Updated to 2013 gpml schema
67083
view
10:04, 26 June 2013
Christine Chichester
Ontology Term : 'biogenic amine biosynthetic pathway' added !
40766
view
21:55, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35159
view
14:37, 11 February 2010
Thomas
Modified description
35158
view
14:37, 11 February 2010
Thomas
added literature
34035
view
18:50, 9 December 2009
MaintBot
Automatic update of empty xrefs
32554
view
13:07, 17 August 2009
MaintBot
Fixed text labels
32236
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12:51, 15 August 2009
MaintBot
Fixed text labels
31744
view
12:01, 14 August 2009
MaintBot
Fixed group labels
31252
view
19:52, 13 August 2009
MaintBot
Fixed text labels
30687
view
22:45, 29 July 2009
MaintBot
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
5-hydroxy-tryptophan
Metabolite
AANAT
GeneProduct
483331 (Entrez Gene)
ACHE
GeneProduct
489828 (Entrez Gene)
ASMT
GeneProduct
Acetylcholine
Metabolite
Acetylserotonin
Metabolite
CHAT
GeneProduct
486775 (Entrez Gene)
COMT
GeneProduct
445450 (Entrez Gene)
Choline
Metabolite
DBH
GeneProduct
448806 (Entrez Gene)
DDC
GeneProduct
606852 (Entrez Gene)
Dopamine
Metabolite
Epinephrine
Metabolite
HMDB00068 (HMDB)
GABA
Metabolite
HMDB00112 (HMDB)
GAD1
GeneProduct
478794 (Entrez Gene)
GAD2
GeneProduct
487107 (Entrez Gene)
Glutamate
Metabolite
HDC
GeneProduct
487551 (Entrez Gene)
Histamine
Metabolite
Histidine
Metabolite
L-DOPA
Metabolite
MAOA
GeneProduct
403450 (Entrez Gene)
Melatonin
Metabolite
HMDB01389 (HMDB)
Norepinephrine
Metabolite
PAH
GeneProduct
475446 (Entrez Gene)
PNMT
GeneProduct
491023 (Entrez Gene)
Phenylalanine
Metabolite
Serotonin
Metabolite
TH
GeneProduct
403444 (Entrez Gene)
TPH1
GeneProduct
Tryptophan
Metabolite
Tyrosine
Metabolite
Annotated Interactions
No annotated interactions
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Annotated Interactions
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