DNA replication (Gallus gallus)

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Orc3Orc2RNA PrimerRFC140Cdc6DNA polymerase alpha:primase: origin complexMcm10Orc complexp180RNA primer-DNA primerOrc4Orc complexCdc6RNA primer-DNA primerDNAPolymerase ARFC40RNA primer-DNA primer:origin duplex:PCNA4. Switching of origins to post-replicative stateOrc complexUbiquitinp49Orc2OriginOrc2Orc5Orc5DNA polymerase alpha:primase: origin complexMcm10Mcm4RFC36Orc3Phosphorylated Cdc6UbiquitinRFC37GemininMcm6Mcm7Cdt1Mcm4Cdc6Orc4Mcm7Orc complexCdc6Mcm 4,6,7 trimer forms andassociates with the replication forkPre-replicative complexOrc5Mcm23. DNA replication initiation2. Activation of the pre-replicative complexMcm3Processive complexp58PrimaseOrc3Cdt1Pre-replicative complexOrc3p70RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerRFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexOrc1Cdt1Cdt1RFC38Phosphorylation ofMcm 2-7 complexMcm3Phosphorylated Orc1Mcm5Cdt1Orc2Mcm5Degraded byproteasomein cytosolOrc complexUbiquitinated Orc1Degraded by proteasome in cytosol5. Leading/lagging strand synthesisMcm6Mcm2Ubiquitinated Cdc6ORC3LCTPRFC1RCJMB04_6d17dUTPRFC5ADPCDC7POLA1MCM4CDT1POLD2PCNAGMNNATPATPCDC45LMCM6ORC4LMCM3UBCATPPOLD1ORC5LCDK2dATPCDC6RFC3DBF4POLE2PRIM2dGTPRFC2ADPMCM7dCTPRFC4MCM5ORC1LPOLD3RPA1POLEUBA52ORC6LGTPRPA3ORC2LRPA4POLD4PRIM1ATPMCM2POLA2UTPMCM10


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 54% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117195view10:32, 18 May 2021EweitzModified title
68859view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
68762view15:29, 7 July 2013EgonwRemoved data source where no ID was given.
67165view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40997view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35218view15:49, 11 February 2010Thomasadded literature
35210view15:44, 11 February 2010ThomasModified description
35204view15:41, 11 February 2010ThomasModified description
33918view18:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33442view14:58, 30 November 2009MaintBotRemoved group label
31499view21:32, 13 August 2009MaintBotFixed text labels
30326view20:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct416776 (Entrez Gene)
CDC6GeneProduct
CDC7GeneProduct424507 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct426254 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct420536 (Entrez Gene)
GMNNGeneProduct421004 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct429525 (Entrez Gene)
MCM2GeneProduct416027 (Entrez Gene)
MCM3GeneProduct422043 (Entrez Gene)
MCM4GeneProduct426764 (Entrez Gene)
MCM5GeneProduct418058 (Entrez Gene)
MCM6GeneProduct424295 (Entrez Gene)
MCM7GeneProduct
ORC1LGeneProduct424640 (Entrez Gene)
ORC2LGeneProduct424077 (Entrez Gene)
ORC3LGeneProduct421822 (Entrez Gene)
ORC4LGeneProduct424307 (Entrez Gene)
ORC5LGeneProduct417714 (Entrez Gene)
ORC6LGeneProduct415749 (Entrez Gene)
PCNAGeneProduct373984 (Entrez Gene)
POLA1GeneProduct418593 (Entrez Gene)
POLA2GeneProduct
POLD1GeneProduct
POLD2GeneProduct
POLD3GeneProduct419053 (Entrez Gene)
POLD4GeneProduct
POLE2GeneProduct423567 (Entrez Gene)
POLEGeneProduct416997 (Entrez Gene)
PRIM1GeneProduct426646 (Entrez Gene)
PRIM2GeneProduct421878 (Entrez Gene)
RCJMB04_6d17GeneProduct419566 (Entrez Gene)
RFC1GeneProduct422788 (Entrez Gene)
RFC2GeneProduct396542 (Entrez Gene)
RFC3GeneProduct418907 (Entrez Gene)
RFC4GeneProduct424958 (Entrez Gene)
RFC5GeneProduct
RPA1GeneProduct417563 (Entrez Gene)
RPA3GeneProduct420578 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct395958 (Entrez Gene)
UBCGeneProduct396425 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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