DNA replication (Canis familiaris)

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Orc2Orc3Phosphorylation ofMcm 2-7 complexRFC40Mcm10Orc complexMcm75. Leading/lagging strand synthesisRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerp70Ubiquitinated Cdc6Orc5Processive complexOrc complexRNA primer-DNA primerDNA polymerase alpha:primase: origin complexRFC38RFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexMcm6DNAPolymerase ARNA primer-DNA primerOrc4UbiquitinOrc3Orc2UbiquitinMcm7Mcm3p180Orc1Phosphorylated Orc1Mcm 4,6,7 trimer forms andassociates with the replication forkRFC36Cdt1Mcm4Mcm5Cdc6Mcm3Cdc6Orc5Mcm5Orc complexOrc2RFC1403. DNA replication initiationOrc3Cdt12. Activation of the pre-replicative complexPre-replicative complexMcm2Orc complexp49RNA primer-DNA primer:origin duplex:PCNAOrc2Cdc6PrimaseOriginp58Degraded by proteasome in cytosolOrc3Pre-replicative complexOrc4GemininCdc6RFC37Cdt1Mcm2RNA PrimerOrc complexCdt1Orc5Mcm6DNA polymerase alpha:primase: origin complexMcm10Phosphorylated Cdc6Degraded byproteasomein cytosol4. Switching of origins to post-replicative stateMcm4Cdt1Ubiquitinated Orc1POLEATPRFC2UTPCDK2ATPDBF4RPA4MCM5GMNNCDC45LRFC1ORC6LGTPADPRPA1UBA52ORC5LMCM4CDC6dATPPOLD4ORC2LMCM10dGTPPOLD1RFC4PCNAPRIM2PRIM1dCTPdUTPRFC3ATPMCM2ATPRFC5MCM6ORC4LPOLD2CDC7POLE2CDT1ORC1LRPA2POLA2ORC3LRPA3POLD3POLA1ADPMCM3UBCCTPMCM7


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 74% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117444view10:52, 21 May 2021EweitzModified title
71479view19:18, 17 October 2013MaintBotAutomated update of data sources
68572view22:58, 5 July 2013MaintBotUpdated to 2013 gpml schema
67157view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40730view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35221view15:53, 11 February 2010Thomasadded literature
35207view15:43, 11 February 2010ThomasModified description
34009view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32545view13:04, 17 August 2009MaintBotFixed text labels
32227view12:48, 15 August 2009MaintBotFixed text labels
31728view11:57, 14 August 2009MaintBotFixed group labels
31243view19:49, 13 August 2009MaintBotFixed text labels
30670view22:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct486421 (Entrez Gene)
CDC6GeneProduct480527 (Entrez Gene)
CDC7GeneProduct479955 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene)
CDT1GeneProduct479616 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct475219 (Entrez Gene)
GMNNGeneProduct478739 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct487128 (Entrez Gene)
MCM2GeneProduct484622 (Entrez Gene)
MCM3GeneProduct481839 (Entrez Gene)
MCM4GeneProduct477871 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM6GeneProduct476131 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
ORC1LGeneProduct475351 (Entrez Gene)
ORC2LGeneProduct478868 (Entrez Gene)
ORC3LGeneProduct474991 (Entrez Gene)
ORC4LGeneProduct476141 (Entrez Gene)
ORC5LGeneProduct609937 (Entrez Gene)
ORC6LGeneProduct482492 (Entrez Gene)
PCNAGeneProduct477166 (Entrez Gene)
POLA1GeneProduct480869 (Entrez Gene)
POLA2GeneProduct476025 (Entrez Gene)
POLD1GeneProduct610047 (Entrez Gene)
POLD2GeneProduct482686 (Entrez Gene)
POLD3GeneProduct476806 (Entrez Gene)
POLD4GeneProduct611847 (Entrez Gene)
POLE2GeneProduct608973 (Entrez Gene)
POLEGeneProduct486223 (Entrez Gene)
PRIM1GeneProduct607309 (Entrez Gene)
PRIM2GeneProduct474950 (Entrez Gene)
RFC1GeneProduct479112 (Entrez Gene)
RFC2GeneProduct489798 (Entrez Gene)
RFC3GeneProduct477308 (Entrez Gene)
RFC4GeneProduct478667 (Entrez Gene)
RFC5GeneProduct477499 (Entrez Gene)
RPA1GeneProduct491196 (Entrez Gene)
RPA2GeneProduct487339 (Entrez Gene)
RPA3GeneProduct481449 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct403722 (Entrez Gene)
UBCGeneProduct610457 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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