TNF-alpha signaling (Homo sapiens)

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EndosomeEndoplasmic reticulum(Protein-protein interaction)ERRecruitmentDeacetylationDemethylationProteolytic cleavageProteins in a complex interactionDesumoylationENCY ->NUInhibitionCY ->NUEnzyme complexDDeubiquitinationMitochondrionLigandPMAccession Number: NetPath 9; cellmap:9AcetylationGolgi apparatusTranslocationCY ->NUCytoplasmMolecular associationMolecule in the pathwayGlycosylationUbiquitinationCY ->NUControlPalmitoylationMethylationMTNUECGOReceptorSumoylationExtracellularReaction through unknown mechanisms/moleculesCY ->NUAutophosphorylationDephosphorylationPlasma membraneNucleusActivationPhosphorylationCYDDX3G3BP2TXLNACASP7CRADDYWHAZNR2C2RELTNFRSF1BRASAL2TNFRSF11ABCL3RELAMAP3K7IP1TRAF5HSP90AB1MTIF2BIRC2TANKFANCD2RPL30NFKBIEGNB2L1Gene SymbolSMARCC1CHUKCDC37TRAF4MAP2K5UBCH5CRPL6NFKBIACASP8AP2TRAF3POLR1DKPNA6NFKB1NFKB2FBLRPS6KB1PTK2PPP2CAPOLR1ATNFYWHAECOMMD1SMARCE1CUL1CDC34FAF1NFKBIAGeneCAPN3PSMD13ALPLHDAC1PDCD2PRAF1TRAF4HSP90AA1TNIP1NKIRAS2PSMD7TRAF1PKN1GeneMCM5LRPPRCFLNAIKBKGIKBKGRIPK2BAG4TBK1PRKACARELBCASP2MEKK2RIPK1TNFTNFRSF1AMAP3K1NFKB1PEG3RIPK3AKT2KPNA3CHUKPOLR1CCFLARRPS13IKBKEHDAC6PIAS3DBC1TNIP2YWHAGT2BPTRAF6PSMC3GeneRIPK1YWHABGSK3BRPL4CASP3MAP3K8PFDN2NSMAFGAB1CSNK2BNALP4NFKBIAFBXW11PSMB5MAP3K14CYLDCASP10KPNA2FADDIQGAP2PSMD6PSMC1TNFKCNQ1CSNK2A2AKT1IKBKAPTRPC4APBIRC2RELATNFMARK2YWHAQNKIRAS1TRAF2SMARCA4TBKBP1MAP3K3PRKCZGLG1IKBKBTNFRSF1ATNFRSF1BHDAC2TAB3BCL7ACREBBPTRAF1COPS3MCCPAPOLATNFUSP11MAP3K3RELBGTF2IMCM7TNFRSF8RPS6KA5PTPN11CSNK2A1PEBP1USP2WDR68DAPSMARCC2RELABIRC3KTN1AZI2TRIAD3HIST3H3SRCTRAIPRPS11DPF2ZA20D2PSMD3CAV1RNF25TRADDSKP1ATRAF2SUMO1ACTL6AASE1BIRC3YWHAHTRAF2UBE2IGenePPP1R13LTNFNFKBIZCASP8STAT1POLR1BMAP3K7IP2RELTNFRSF1APOLRY2HPSMC2NFKB1NFKBIBTRADDSMARCB1HSPB1PSMD1AKAP8PMLRELAPOLR2LNR2C2PSMD12RPL8TBK1UNC5CLTNFRSF1BFKBP5TNFAIP3BTRCUBCH5B


Description

"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor superfamily. Activation by the homotrimeric ligand results in receptor trimerization. TNFRSF1A trimers result in the activation of NF-kB through MAPK and caspase pathways leading to apoptosis, whereas a heterocomplex of both TNFRSF1A and TNFRSF1B recruits proteins such as BIRC2 and BIRC3, which are apoptotic inhibitors. As both TNF alpha and IL-1 stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity." Source: http://www.netpath.org/pathways?path_id=NetPath_9

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
129710view01:30, 22 May 2024EweitzModified title
124583view05:13, 13 November 2022EgonwRemoved outdated license info: all CCZero now
124582view05:11, 13 November 2022EgonwConverted a label ("ROS") to a metabolite node with identifier
120699view13:12, 23 December 2021EweitzStandardize font, weight, case
116472view10:16, 7 May 2021EweitzModified title
111053view14:57, 3 July 2020L DupuisConverted interactions to graphical lines in legend
105836view23:09, 15 August 2019KhanspersModified description
89895view13:10, 6 October 2016EgonwModified description
81070view19:14, 19 July 2015EgonwAdded three missing ChEBI metabolite IDs.
79942view08:40, 28 April 2015Zariadded annotation for RAS
79280view22:53, 19 March 2015ZariAdded Identifier for SELE,CCL2 and NOXO1
78500view10:28, 7 January 2015MaintBotadded missing graphIds
72093view21:34, 24 October 2013Mkutmonadded datasource to "TNF"
71708view20:00, 17 October 2013MaintBotremoved data source from nodes without identifier
70103view18:53, 12 July 2013MaintBotupdated to 2013 schema
67700view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
47978view14:38, 23 April 2012NetPathModified description
44640view18:30, 22 September 2011Khanspersadded description
44639view18:29, 22 September 2011KhanspersModified categories
44638view18:29, 22 September 2011KhanspersUpdating content to NetSlim
41210view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
36762view19:39, 29 April 2010Khansperstest
35303view23:33, 11 February 2010NsalomonisModified description
32365view13:44, 15 August 2009MaintBotFixed text labels
32004view13:18, 14 August 2009MaintBotFixed group labels
28972view11:00, 19 March 2009EveloSpecify description
28971view10:54, 19 March 2009EveloJus alignments
28970view10:42, 19 March 2009Evelocleaned up a bit
28911view08:09, 12 March 2009AlexanderPicoconnecting edges
28908view07:04, 12 March 2009AlexanderPicoconnecting edges
28907view06:23, 12 March 2009AlexanderPicoconnecting edges
28906view05:04, 12 March 2009Burakconnected the edges
28905view04:54, 12 March 2009BurakPeriodical save, work in progress
21163view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP231]]: Moved to stable identifier
8446view13:46, 7 January 2008MaintBot[[Pathway:Human:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7839view16:21, 18 December 2007MaintBotfixed category names
7307view12:42, 4 November 2007MaintBotAdded categories to GPML
6399view22:18, 22 May 2007A.Pandeygpml file for [[Human:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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ZA20D2GeneProduct7763 (Entrez Gene)

Annotated Interactions

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