Matrix metalloproteinases (Canis familiaris)
From WikiPathways
Description
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.
Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.
Source: WikipediaQuality Tags
Ontology Terms
Bibliography
- Vu TH, Werb Z; ''''; , PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
BSG | GeneProduct | ||
MMP10 | GeneProduct | ||
MMP11 | GeneProduct | 486408 (Entrez Gene) | |
MMP12 | GeneProduct | 611789 (Entrez Gene) | |
MMP13 | GeneProduct | 403763 (Entrez Gene) | |
MMP14 | GeneProduct | 403823 (Entrez Gene) | |
MMP1 | GeneProduct | 489428 (Entrez Gene) | |
MMP15 | GeneProduct | 487257 (Entrez Gene) | |
MMP16 | GeneProduct | 487036 (Entrez Gene) | |
MMP17 | GeneProduct | 609890 (Entrez Gene) | |
MMP19 | GeneProduct | 606853 (Entrez Gene) | |
MMP20 | GeneProduct | 611829 (Entrez Gene) | |
MMP21 | GeneProduct | 611418 (Entrez Gene) | |
MMP23A | GeneProduct | ||
MMP23B | GeneProduct | 607187 (Entrez Gene) | |
MMP2 | GeneProduct | 403733 (Entrez Gene) | |
MMP24 | GeneProduct | 485849 (Entrez Gene) | |
MMP25 | GeneProduct | 490046 (Entrez Gene) | |
MMP26 | GeneProduct | 610101 (Entrez Gene) | |
MMP27 | GeneProduct | 489430 (Entrez Gene) | |
MMP28 | GeneProduct | 491136 (Entrez Gene) | |
MMP3 | GeneProduct | 403445 (Entrez Gene) | |
MMP7 | GeneProduct | 489432 (Entrez Gene) | |
MMP8 | GeneProduct | 489429 (Entrez Gene) | |
MMP9 | GeneProduct | 403885 (Entrez Gene) | |
TCF20 | GeneProduct | 481224 (Entrez Gene) | |
TIMP1 | GeneProduct | 403816 (Entrez Gene) | |
TIMP2 | GeneProduct | 403633 (Entrez Gene) | |
TIMP3 | GeneProduct | 481289 (Entrez Gene) | |
TIMP4 | GeneProduct | ||
TNF | GeneProduct | 403922 (Entrez Gene) |
Annotated Interactions
No annotated interactions