Synthesis and degradation of ketone bodies (Rattus norvegicus)
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1
Fatty acid beta-oxidation
Fatty acid metabolism
Glycolysis
(HMG-CoA cycle)
Pyruvate metabolism
* pathway-regulated enzymes: HMG-CoA synthase, mt
Sterol biosynthesis
Hmgcs2
Acetoacetate
Acat1
Oxct1
Hmgcl
3-Hydroxy-3-methylglutaryl-CoA
Acetyl-CoA
Acetoacetyl-CoA
Acetyl-CoA
3-Hydroxy-butyrate
Bdh1
Description
No description
Comments
GenMAPP notes
Ketogenesis (Human)
GenMAPP remarks
Adapted from KEGG
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP311(r21335)
with a 55% conversion rate.
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Bibliography
Fukao T, Lopaschuk GD, Mitchell GA; ''Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.''; Prostaglandins Leukot Essent Fatty Acids, 2004
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117020
view
11:36, 16 May 2021
Eweitz
Modified title
106980
view
13:43, 17 September 2019
MaintBot
HMDB identifier normalization
105001
view
04:51, 28 June 2019
Khanspers
removed KEGG comments
69425
view
19:03, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67676
view
11:48, 26 June 2013
Ddigles
Ontology Term : 'ketone bodies metabolic pathway' added !
60203
view
15:36, 14 March 2013
Susan
Add metabolites id
48271
view
23:16, 17 May 2012
Khanspers
Updating PubChem xrefs
48259
view
21:58, 17 May 2012
MaintBot
Automatic update of PubChem xrefs
41748
view
02:40, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35391
view
09:37, 12 February 2010
Thomas
fixed connections
35365
view
09:14, 12 February 2010
Thomas
fixed metabolite annotations
35360
view
09:10, 12 February 2010
Thomas
Modified description
35357
view
09:08, 12 February 2010
Thomas
added literature
34119
view
19:26, 9 December 2009
MaintBot
Automatic update of empty xrefs
30962
view
00:46, 30 July 2009
MaintBot
Converted from Homo sapiens
21411
view
11:31, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:WP349]]: Moved to stable identifier
8424
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:Rattus norvegicus:Synthesis and Degradation of Ketone Bodies KEGG]]: Renaming species
7829
view
16:20, 18 December 2007
MaintBot
fixed category names
7403
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6599
view
22:20, 22 May 2007
N.Reyes
gpml file for [[Rat:Synthesis_and_Degradation_of_Ketone_Bodies_KEGG]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
3-Hydroxy-3-methylglutaryl-CoA
Metabolite
3-Hydroxy-butyrate
Metabolite
3037032 (PubChem)
Acat1
GeneProduct
25014 (Entrez Gene)
Acetoacetate
Metabolite
6971017 (PubChem)
Acetoacetyl-CoA
Metabolite
Acetyl-CoA
Metabolite
Bdh1
GeneProduct
117099 (Entrez Gene)
Hmgcl
GeneProduct
79238 (Entrez Gene)
Hmgcs2
GeneProduct
24450 (Entrez Gene)
Oxct1
GeneProduct
690163 (Entrez Gene)
Annotated Interactions
No annotated interactions
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