Cell cycle (Rattus norvegicus)

From WikiPathways

Revision as of 09:12, 12 February 2010 by MartijnVanIersel (Talk | contribs)
Jump to: navigation, search
1mediated+pS-phase proteinsG2Histone DeacetylasesS+pep27,57(Start)+pDNA damage checkpoint+p+pSecurin+u+pApoptosisGrowth Factor+p+pMR-point+peMCM (Mini-ChromosomeMaintenance) complexproteolysis+uHDACp21G1+u+pSeparinDNA+pTranscription Factor E2Fesignaling+u+ppathway+pUbiquitin-p-p+p+pGrowth Factor withdrawalORC (OriginRecognition complex)DNA biosynthesis+u+pp16,15,18,19DNA+pMAPKCondensineeBub1bEspl1Tp53Rb1Orc3lGsk3bSmad3Smad4Hdac4Cdh1Bub1Ccne2Ccnb3E2f6Cdc14bHdac1Cdkn1bARFMCMEp300Mdm2Orc6lUBE2FHdac3SCFE2f5Cdc25bMcm2Chek2YwhagMcm4Mpeg1Cdc14aMcm6Smc1aCdc6Cdc7SCFOrc5lMAD2L214-3-3Cdkn2aCdk2Ccnd2ATRCdkn1aHDAC5Orc2lCdk4E2f1Pttg1ORCChek1Cdc2E2FHdac7Dbf4Hdac6APC/CCcna1Orc1lE2F2Cdc20Mad2l1Skp2Ccna2Ccne1APC/CAbl1Pkmyt1Tgfb1Mcm3PcnaRb1Ccnb2Cdc25aSkp2Gadd45aOrc4lHdac8Ccnb1Mad1l1LOC680133Ccna2Cdk2BUB3Ccna1CcnhPTTG2E2F4Rb1E2f3AtmCdk2Cdc25cMcm5Cdk6Cdc45lGeneProductWee1Rbl1PrkdcPTTG3Ccnd3Cdc2Plk1Hdac2Rbl1TFDP1MENMcm7


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
GenMAPP remarks 
Right-click here to see notes
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 81% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
109404view17:38, 16 March 2020L DupuisFixed interactions
89530view11:04, 16 September 2016Mkutmonontology tag fix
89483view13:39, 15 September 2016Mkutmonremove space from ontology term id
71805view20:34, 17 October 2013MaintBotAutomated update of data sources
71308view17:00, 17 October 2013MaintBotAutomated update of data sources
69449view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
67104view10:07, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62853view05:07, 3 May 2013MaintBotUpdated UniProt data source
41778view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
35362view09:12, 12 February 2010MartijnVanIerselModified description
34146view19:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32429view17:12, 15 August 2009MaintBotFixed text labels
32092view13:42, 14 August 2009MaintBotFixed group labels
31449view21:10, 13 August 2009MaintBotFixed text labels
31022view01:08, 30 July 2009MaintBotConverted from Homo sapiens
21584view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Cell cycle KEGG]] moved to [[Pathway:WP429]]: Moved to stable identifier
7952view13:46, 7 January 2008MaintBot[[Pathway:Rat:Cell cycle KEGG]] moved to [[Pathway:Rattus norvegicus:Cell cycle KEGG]]: Renaming species
7600view16:03, 18 December 2007MaintBotfixed category names
7208view12:33, 4 November 2007MaintBotAdded categories to GPML
19399view22:19, 22 May 2007BruceConklingpml file for [[Rat:Cell_cycle_KEGG]]
6524view22:19, 22 May 2007Nsalomonisgpml file for [[Rat:Cell_cycle_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
APC/CGeneProduct
ARFGeneProduct
ATRGeneProduct300942 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
Abl1GeneProduct311860 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
AtmGeneProduct300711 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
BUB3GeneProduct361662 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Bub1GeneProduct296137 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
Bub1bGeneProduct171576 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Ccna1GeneProduct295052 (Entrez Gene) CCNA1; cyclin A1
Ccna2GeneProduct114494 (Entrez Gene) CCNA2; cyclin A2
Ccnb1GeneProduct25203 (Entrez Gene) CCNB1; cyclin B1
Ccnb2GeneProduct363088 (Entrez Gene) CCNB2; cyclin B2
Ccnb3GeneProduct317389 (Entrez Gene) CCNB3; cyclin B
Ccnd2GeneProduct64033 (Entrez Gene) CCND2; cyclin D2
Ccnd3GeneProduct25193 (Entrez Gene) CCND3; cyclin D3
Ccne1GeneProduct25729 (Entrez Gene) CCNE1; cyclin E
Ccne2GeneProduct362485 (Entrez Gene) CCNE2; cyclin E
CcnhGeneProduct84389 (Entrez Gene) CCNH; cyclin H
Cdc14aGeneProduct310806 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
Cdc14bGeneProduct361195 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
Cdc20GeneProduct64515 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
Cdc2GeneProduct54237 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
Cdc25aGeneProduct171102 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
Cdc25bGeneProduct171103 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
Cdc25cGeneProduct307511 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
Cdc45lGeneProduct287961 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
Cdc6GeneProduct360621 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
Cdc7GeneProduct360908 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
Cdh1GeneProduct83502 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
Cdk4GeneProduct94201 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
Cdk6GeneProduct114483 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
Cdkn1aGeneProduct114851 (Entrez Gene)
Cdkn1bGeneProduct83571 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
Cdkn2aGeneProduct25163 (Entrez Gene)
Chek1GeneProduct140583 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Chek2GeneProduct114212 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Dbf4GeneProduct312046 (Entrez Gene) ASK; activator of S phase kinas
E2FGeneProduct
E2F2GeneProductE2F2; E2F transcription factor 2
E2F4GeneProduct307794 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2f1GeneProduct399489 (Entrez Gene) E2F1; E2F transcription factor 1
E2f3GeneProduct291105 (Entrez Gene) E2F3; E2F transcription factor 3
E2f5GeneProduct116651 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2f6GeneProduct313978 (Entrez Gene) E2F6; E2F transcription factor 6
Ep300GeneProduct170915 (Entrez Gene) EP300; E1A binding protein p300
Espl1GeneProduct315330 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
Gadd45aGeneProduct25112 (Entrez Gene)
GeneProductGeneProduct
Gsk3bGeneProduct84027 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
HDAC5GeneProduct84580 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac1GeneProduct297893 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct84577 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct84578 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct363287 (Entrez Gene) HDAC4; histone deacetylase 4
Hdac6GeneProduct84581 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7GeneProduct84582 (Entrez Gene) HDAC7A; histone deacetylase 7
Hdac8GeneProduct363481 (Entrez Gene) HDAC8; histone deacetylase
LOC680133GeneProduct680133 (Entrez Gene)
MAD2L2GeneProduct313702 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MENGeneProduct
Mad1l1GeneProduct680006 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
Mad2l1GeneProduct297176 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
Mcm2GeneProduct312538 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Mcm3GeneProduct316273 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Mcm4GeneProduct29728 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
Mcm5GeneProduct291885 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Mcm6GeneProduct29685 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Mcm7GeneProduct288532 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Mdm2GeneProduct314856 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
Mpeg1GeneProduct64552 (Entrez Gene)
ORCGeneProduct
Orc1lGeneProduct313479 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
Orc2lGeneProduct301430 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
Orc3lGeneProduct313138 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
Orc4lGeneProduct295596 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
Orc5lGeneProduct362304 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
Orc6lGeneProduct291927 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PTTG2GeneProduct360936 (Entrez Gene) PTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
PcnaGeneProduct25737 (Entrez Gene) PCNA; proliferating cell nuclear antigen
Pkmyt1GeneProduct287101 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
Plk1GeneProduct25515 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PrkdcGeneProduct360748 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
Pttg1GeneProduct64193 (Entrez Gene) PTTG1; pituitary tumor-transforming
Rb1GeneProduct24708 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
Rbl1GeneProduct680111 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SCFGeneProduct
Skp2GeneProduct294790 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
Smad3GeneProduct25631 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
Smad4GeneProduct50554 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Smc1aGeneProduct63996 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TFDP1GeneProductTFDP1; transcription factor Dp-1
Tgfb1GeneProduct59086 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
UBE2FGeneProduct363284 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
Wee1GeneProduct308937 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YwhagGeneProduct56010 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP429"
Personal tools