Cell cycle (Mus musculus)

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+p+p+pR-pointAPC/C+pe(Start)+pSCFsignalingSeApoptosisMaintenance) complexORC (OriginDNAMAPKp21E2FUbiquitinmediated+pTranscription Factor E2F+u+u+p-p+pS-phase proteins+up27,57G1Recognition Complex)Mwithdrawalepathway+p+pDNA biosynthesisp16,15,18,19+uCondensineG2+uAPC/C+p+p+pORCDNA damage checkpoint-pSCFeGrowth FactorDNAMCM+p+pSeparinproteolysisHistone Deacetylases+pSecurin+pGrowth FactorMCM (Mini-ChromosomeHDACMcm6Cdc25bOrc2lMad2l2E2f6Orc4lMcm4Mad2l1CcnhHdac1-psRb1Tfdp1Cdc45lMdm2Cdc25aCcnb1Espl1Tgfb1MENPkmyt1E2f5Hdac5Hdac3E2f1Tbc1d8PcnaBub1bCcnb3Cdkn2aRbl1Ccnd2Cdk2E2f3Orc1l14-3-3YwhagPttg1ARFCdh1Abl1Cdc2aBub1Ep300Rbl1Mcm5Cdkn1aCcna2Mcm3Orc3lCdc7Ccne1Cdc20Ccnb2Cdc2aHdac2Ccna1Wee1Skp2Cdk2Ccna2Ccne2Cdk2Orc5lCcna1AA545217Rb1Gadd45aHdac4Cdc14BMcm2Hdac7aAtrAtmPrkdcOrc6lCdk6Cdc25cHdac6Cdc6Skp2Cdkn1bCcnd3Smad3Smc1l2Cdk4Mpeg1Rb1Smad4Mad1l1Gsk3bPlk1Bub3Trp53Chek2AL118125Mcm7Cdc14AE2f2E2f4Chek1


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
GenMAPP remarks 
Right-click here to see notes

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Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
89518view11:00, 16 September 2016Mkutmonontology tag fix
89476view13:39, 15 September 2016Mkutmonremove space from ontology term id
81191view13:47, 3 August 2015Mkutmonfix invalid xref
71755view20:20, 17 October 2013MaintBotUpdated data sources
67102view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62828view04:41, 3 May 2013MaintBotupdated uniprot data source
41247view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
35363view09:13, 12 February 2010MartijnVanIerselModified description
34372view22:42, 9 December 2009MaintBotAutomatic update of empty xrefs
21079view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Cell cycle KEGG]] moved to [[Pathway:WP190]]: Moved to stable identifier
10210view18:28, 16 January 2008MaintBotSpecify description
19398view13:26, 11 January 2008BruceConklinrestored missing GPML
10045view13:26, 11 January 2008Nsalomonisrestored missing GPML

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
AA545217GeneProduct27214 (Entrez Gene) ASK; activator of S phase kinas
AL118125GeneProduct404565 (Entrez Gene)
  • «208727[L] »
  • Hdac4; histone deacetylase 4
ARFGeneProduct
Abl1GeneProduct11350 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
AtmGeneProduct11920 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
AtrGeneProduct245000 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
Bub1GeneProduct12235 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
Bub1bGeneProduct12236 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Bub3GeneProduct12237 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Ccna1GeneProduct12427 (Entrez Gene) CCNA1; cyclin A1
Ccna2GeneProduct12428 (Entrez Gene) CCNA2; cyclin A2
Ccnb1GeneProduct268697 (Entrez Gene)
Ccnb2GeneProduct12442 (Entrez Gene) CCNB2; cyclin B2
Ccnb3GeneProduct209091 (Entrez Gene) CCNB3; cyclin B - see SP:Q8VDC5
Ccnd2GeneProduct12444 (Entrez Gene) CCND2; cyclin D2
Ccnd3GeneProduct12445 (Entrez Gene) CCND3; cyclin D3
Ccne1GeneProduct12447 (Entrez Gene) CCNE1; cyclin E
Ccne2GeneProduct12448 (Entrez Gene) CCNE2; cyclin E
CcnhGeneProduct66671 (Entrez Gene) CCNH; cyclin H
Cdc14AGeneProduct229776 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
Cdc14BGeneProduct218294 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
Cdc20GeneProduct107995 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
Cdc25aGeneProduct12530 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
Cdc25bGeneProduct12531 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
Cdc25cGeneProduct12532 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
Cdc2aGeneProduct12534 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
Cdc45lGeneProduct12544 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
Cdc6GeneProduct23834 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
Cdc7GeneProduct12545 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
Cdh1GeneProduct12550 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
Cdk4GeneProduct12567 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
Cdk6GeneProduct12571 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
Cdkn1aGeneProduct12575 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Chek1GeneProduct12649 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Chek2GeneProduct50883 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
E2f1GeneProduct13555 (Entrez Gene) E2F1; E2F transcription factor 1
E2f2GeneProduct242705 (Entrez Gene) E2F2; E2F transcription factor 2
E2f3GeneProduct13557 (Entrez Gene) E2F3; E2F transcription factor 3
E2f4GeneProduct104394 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2f5GeneProduct13559 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2f6GeneProduct50496 (Entrez Gene) E2F6; E2F transcription factor 6
Ep300GeneProduct328572 (Entrez Gene) EP300; E1A binding protein p300
Espl1GeneProduct105988 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
Gadd45aGeneProduct13197 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
Hdac1-psGeneProduct15181 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct15182 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct15183 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct208727 (Entrez Gene)
  • «208727[L] »
  • Hdac4; histone deacetylase 4
Hdac5GeneProduct15184 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac6GeneProduct15185 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7aGeneProduct56233 (Entrez Gene) HDAC7A; histone deacetylase 7
MENGeneProduct
Mad1l1GeneProduct17120 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
Mad2l1GeneProduct56150 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
Mad2l2GeneProduct71890 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
Mcm2GeneProduct17216 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Mcm3GeneProduct17215 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Mcm4GeneProduct17217 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
Mcm5GeneProduct17218 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Mcm6GeneProduct17219 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Mcm7GeneProduct17220 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Mdm2GeneProduct17246 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
Mpeg1GeneProduct17476 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
Orc2lGeneProduct18393 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
Orc3lGeneProduct50793 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
Orc4lGeneProduct26428 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
Orc5lGeneProduct26429 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
Orc6lGeneProduct56452 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PcnaGeneProduct18538 (Entrez Gene) PCNA; proliferating cell nuclear antigen
Pkmyt1GeneProduct268930 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
Plk1GeneProduct18817 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PrkdcGeneProduct19090 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
Pttg1GeneProduct30939 (Entrez Gene) PTTG1; pituitary tumor-transforming
Rb1GeneProduct19645 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
Rbl1GeneProduct19650 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
Skp2GeneProduct27401 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
Smad3GeneProduct17127 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
Smad4GeneProduct17128 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Smc1l2GeneProduct140557 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
Tbc1d8GeneProduct54610 (Entrez Gene)
Tfdp1GeneProduct21781 (Entrez Gene) TFDP1; transcription factor Dp-1
Tgfb1GeneProduct21803 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wee1GeneProduct22390 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YwhagGeneProduct22628 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP190"
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