Ketone bodies synthesis and degradation (Canis familiaris)

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* pathway-regulated enzymes: HMG-CoA synthase, mtFatty acid beta-oxidationFatty acid metabolismSterol biosynthesisGlycolysis(HMG-CoA cycle)Pyruvate metabolismAcetoacetateAcetyl-CoAHMGCLHMGCS23-Hydroxy-3-methylglutaryl-CoAAcetyl-CoAAcetoacetyl-CoABDH1OXCT13-Hydroxy-butyrateACAT1


Description

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia

Comments

GenMAPP notes 
Ketogenesis (Human)
GenMAPP remarks 
Adapted from KEGG
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP311(r21335) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
117463view10:56, 21 May 2021EweitzModified title
68565view22:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
67673view11:47, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
48300view04:08, 18 May 2012KhanspersUpdating PubChem xrefs
48299view04:07, 18 May 2012MaintBotAutomatic update of PubChem xrefs
40723view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35381view09:21, 12 February 2010Thomasadded literature, fixed metabolite xrefs
35371view09:15, 12 February 2010ThomasModified description
34002view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
30703view22:50, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite
3-Hydroxy-butyrateMetabolite3037032 (PubChem)
ACAT1GeneProduct489421 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem)
Acetoacetyl-CoAMetabolite
Acetyl-CoAMetabolite
BDH1GeneProduct488037 (Entrez Gene)
HMGCLGeneProduct478187 (Entrez Gene)
HMGCS2GeneProduct607923 (Entrez Gene)
OXCT1GeneProduct479347 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1134"
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