Ketone bodies synthesis and degradation (Gallus gallus)

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* pathway-regulated enzymes: HMG-CoA synthase, mtFatty acid beta-oxidationFatty acid metabolismSterol biosynthesisGlycolysis(HMG-CoA cycle)Pyruvate metabolismAcetoacetateAcetyl-CoAHMGCLHMGCS23-Hydroxy-3-methylglutaryl-CoAAcetyl-CoAAcetoacetyl-CoABDH1OXCT13-Hydroxy-butyrateACAT1


Description

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia

Comments

GenMAPP notes 
Ketogenesis (Human)
GenMAPP remarks 
Adapted from KEGG
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP311(r21335) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fukao T, Lopaschuk GD, Mitchell GA; ''Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.''; Prostaglandins Leukot Essent Fatty Acids, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117187view10:25, 18 May 2021EweitzModified title
68818view17:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67679view11:48, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
48306view04:21, 18 May 2012KhanspersUpdating PubChem xrefs
48304view04:19, 18 May 2012MaintBotAutomatic update of PubChem xrefs
40953view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35392view09:38, 12 February 2010Thomasfixed connections
35383view09:25, 12 February 2010Thomasadded literature, fixed metabolite xrefs
35376view09:17, 12 February 2010ThomasModified description
33880view17:53, 9 December 2009MaintBotAutomatic update of empty xrefs
30353view20:53, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite
3-Hydroxy-butyrateMetabolite3037032 (PubChem)
ACAT1GeneProduct418968 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem)
Acetoacetyl-CoAMetabolite
Acetyl-CoAMetabolite
BDH1GeneProduct424891 (Entrez Gene)
HMGCLGeneProduct396316 (Entrez Gene)
HMGCS2GeneProduct424380 (Entrez Gene)
OXCT1GeneProduct427190 (Entrez Gene)

Annotated Interactions

No annotated interactions
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