G13 signaling pathway (Bos taurus)

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1CytokinesisG13Contraction & Actin-MyosinInteraction, Focal AdhesionStress Fiber ContractionActivated Rho AActin PolymerizationDisassembly of ActinAnti-ApoptoticActin PolymerizationFilopodia FormationStress FiberDisappearanceActin ReorganizationCell-Cell AdhesionMembraneRufflingMAPK10PIK3CACDC42RTKNPIP4K2APIK3CBPAK3MYBPHPIK3R2WASLRPS6KB1CITIQGAP2MAP3K4PKN1CFL2ARHGDIGLOC786565SH3RF1ROCK1ROCK2IQGAP1LOC505611RHPN2CFL1PFN1CALM1RHOAp140 Sra-1PPP1CBARHGDIBTNK2PIK3CDRAC1LIMK1ARHGEF1WASMYL1


Description

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP524(r21780) with a 78% conversion rate.

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Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117519view11:08, 21 May 2021EweitzModified title
95752view14:07, 19 January 2018MkutmonHomology conversion update
80871view15:29, 30 June 2015Mkutmonhomology conversion
72019view12:39, 24 October 2013Mkutmonfixed unconnected lines
71394view19:00, 17 October 2013MaintBotAutomated update of data sources
67273view10:30, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
63313view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
62700view23:16, 1 May 2013MaintBotUpdated UniProt data source
40494view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35421view10:44, 12 February 2010ThomasModified description
35420view10:44, 12 February 2010Thomasadded literature, fixed connection
33738view23:55, 8 December 2009MaintBotAutomatic update of empty xrefs
32521view12:56, 17 August 2009MaintBotFixed text labels
32370view16:35, 15 August 2009MaintBotFixed text labels
32208view12:41, 15 August 2009MaintBotFixed text labels
31696view11:48, 14 August 2009MaintBotFixed group labels
31219view19:41, 13 August 2009MaintBotFixed text labels
30632view22:26, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARHGDIBGeneProduct327676 (Entrez Gene)
ARHGDIGGeneProduct613745 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CFL1GeneProduct534553 (Entrez Gene)
CFL2GeneProduct539332 (Entrez Gene)
CITGeneProduct786852 (Entrez Gene)
IQGAP1GeneProduct532715 (Entrez Gene)
IQGAP2GeneProduct
LIMK1GeneProduct535225 (Entrez Gene)
LOC505611GeneProduct505611 (Entrez Gene)
LOC786565GeneProduct786565 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MYBPHGeneProduct510169 (Entrez Gene)
MYL1GeneProduct317657 (Entrez Gene)
PAK3GeneProduct534526 (Entrez Gene)
PFN1GeneProduct781603 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene) P42338
PIK3R2GeneProduct282308 (Entrez Gene)
PIP4K2AGeneProduct533289 (Entrez Gene)
PKN1GeneProduct509080 (Entrez Gene)
PPP1CBGeneProduct538829 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
RHPN2GeneProduct533687 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene) S69211
ROCK2GeneProduct282041 (Entrez Gene) BAA31594
RPS6KB1GeneProduct404181 (Entrez Gene) A41687
RTKNGeneProduct539691 (Entrez Gene)
SH3RF1GeneProduct528315 (Entrez Gene) Posh
TNK2GeneProductS33596
WASGeneProduct
WASLGeneProduct281577 (Entrez Gene)
p140 Sra-1GeneProduct

Annotated Interactions

No annotated interactions
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