G13 signaling pathway (Canis familiaris)

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1Contraction & Actin-MyosinInteraction, Focal AdhesionStress Fiber ContractionActivated Rho AActin PolymerizationCytokinesisMembrane RufflingGActin PolymerizationFilopodia FormationActin ReorganizationCell-Cell AdhesionDisassembly of ActinStress Fiber DisappearanceAnti-Apoptotic13MYBPHPIK3CDWASARHGDIGPKN1CFL2CITARHGDIBPFN1p140 Sra-1ROCK2IQGAP2ARHGEF1ROCK1MYL1PPP1CBRTKNLIMK1TNK2PIP4K2APIK3CBSH3RF1PIK3CARPS6KB1RHOACALM1RHPN2MAPK10CDC42DIAPH1RAC1MAP3K4WASLCFL1PAK3GNA13PIK3R2IQGAP1


Description

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP524(r21780) with a 84% conversion rate.

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Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117451view10:53, 21 May 2021EweitzModified title
95739view13:26, 19 January 2018Mkutmonupdated homology conversion
71475view19:18, 17 October 2013MaintBotAutomated update of data sources
68567view22:52, 5 July 2013MaintBotUpdated to 2013 gpml schema
67274view10:30, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
62723view03:17, 2 May 2013MaintBotUpdated UniProt data source
40725view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35423view10:50, 12 February 2010ThomasModified description
35422view10:49, 12 February 2010Thomasremoved braces, fixed labels, added literature,
34004view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32371view16:39, 15 August 2009MaintBotFixed text labels
32263view13:02, 15 August 2009MaintBotFixed text labels
31790view12:15, 14 August 2009MaintBotFixed group labels
31290view20:07, 13 August 2009MaintBotFixed text labels
30748view23:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARHGDIBGeneProduct486666 (Entrez Gene)
ARHGDIGGeneProduct611541 (Entrez Gene)
ARHGEF1GeneProduct
CALM1GeneProduct480416 (Entrez Gene)
CDC42GeneProduct607535 (Entrez Gene)
CFL1GeneProduct476022 (Entrez Gene)
CFL2GeneProduct490649 (Entrez Gene)
CITGeneProduct
DIAPH1GeneProduct
GNA13GeneProduct490901 (Entrez Gene)
IQGAP1GeneProduct479050 (Entrez Gene)
IQGAP2GeneProduct479177 (Entrez Gene)
LIMK1GeneProduct489800 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MYBPHGeneProduct490223 (Entrez Gene)
MYL1GeneProduct478896 (Entrez Gene)
PAK3GeneProduct492067 (Entrez Gene)
PFN1GeneProduct
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene) P42338
PIK3R2GeneProduct609956 (Entrez Gene)
PIP4K2AGeneProduct608414 (Entrez Gene)
PKN1GeneProduct484903 (Entrez Gene)
PPP1CBGeneProduct403558 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
RHPN2GeneProduct403518 (Entrez Gene)
ROCK1GeneProduct480181 (Entrez Gene) S69211
ROCK2GeneProduct482970 (Entrez Gene) BAA31594
RPS6KB1GeneProduct480580 (Entrez Gene) A41687
RTKNGeneProduct475788 (Entrez Gene)
SH3RF1GeneProduct612744 (Entrez Gene) Posh
TNK2GeneProduct488025 (Entrez Gene) S33596
WASGeneProduct491867 (Entrez Gene)
WASLGeneProduct475213 (Entrez Gene)
p140 Sra-1GeneProduct

Annotated Interactions

No annotated interactions
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