EGFR1 signaling pathway (Mus musculus)

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1CYProteins in a complex interactionNUMACYPMMolecule in the pathwayMANUPMPMCYECPMCYPMMANULigandPMAutodephosphorylationNUCYPMPMMAReceptorGolgi apparatusRecruitmentGene SymbolPMPMNUPMExtracellularNUPMNucleusGlycosylationPMNUCYMACYCYCYSumoylationMAActivationPMNUCYNUPMMACYMA(Protein-protein interaction)CYDesumoylationCYNUCYMANUMADeacetylationPMCYCYDeubiquitinationCYMAMAInhibitionPhosphorylationPalmitoylationCYReaction through unknown mechanisms/moleculesMACYCYMATranslocationGOMANUCYCYCYMAPMNUAutophosphorylationCYDCYENEndoplasmic reticulumERDephosphorylationMAMTCYDemethylationMACYMethylationPMENPMAcetylationNUMolecular associationPMProteolytic cleavageControlENPlasma membraneMAPMPMNUAccession Number : NetPath 4; cellmap:4NUDUbiquitinationCYMANUCYNUCYCYMitochondrionCYCytoplasmCYNUMAEnzyme complexDNUCYEndosomeCYPlscr1Mapk3FosSh2d3cLOC382523Pik3r3EgfrArafRps6ka1Ptpn6Eps15l1Pik3cbSh3bgrlKrt1-18Stat3Sh2d3cSos1Pik3cgPrkcaCeacam1Jund1Zfp259Gab1Raf1Reps2EgfEgfRps6ka3CrkStat2Dusp1Ctnnd1TgifMap2k1ATF1Creb1Jak2Arf42900057D21RikPkn2Stxbp1Nck2EgfMycGrb10Krt2-8Pik3c2bRbbp7Shc12900057D21RikEgfrStat1Pik3r2Sh3gl3Snrpd2Inppl1Epn1Rab5aPrkczPik3cdHras1Mapk14CskStat2Sp1Ptpn12Map3k4Sh3kbp1Tnk2Map3k14JunElk1Pld1Plcg1Smad2Prkcb1Sin3aPrkcmCebpaKrasJak1Shc1Pak1Rac1Errfi1Map2k3Rps6ka5Smad2Ap2a1Vav1Dok2Stat5aRipk1EgfrKrt1-17Eps15Raf1Elk4Plec12900057D21RikStat5aPrkcaStat3Arf4Stat1Stat5bMapk7HdhCdc42Gja1Pld2NrasStat1Prkar1aDdef1Arf4RalbPrkciElf3SncaRasa1Dip3bPitpnaTnip1Bcar1Map2k7Akt1Bcar1Casp9Dusp1EPPK1Grb2Camk2aPRKCGSocs1CrklRgs16Ptpn5Sh3gl2Plcg2ABI1Map3k2Eef1a1Gab2Grb14Map3k2Mapk1Mapk1Eef1a1Vav3PtprrMcf2WaslYwhabSpry2Vav2PxnDip3bKrt2-7Dnm1MAP3K1RfxankItchFoxo1PIK3R1Git1Ptk6Wnk1Map2k5Plcg2Stat3Spry2Ndufa13Rps6ka3EgfrCebpbPlcg1Pebp1Stxbp1Pld1Shoc2Mta2Ptpn6Map3k3Nck1Rps6ka2Smad3Zfp259Tieg3Elf3Hat1RalgdsSocs3Gab1Ralbp1Ptk2bReps1CblbMapk8CblcPik3caSh3gl2Map2k1Ptpn11Smad3Cav1Sos2Hip1CblUsp6nlHdac1Map2k2Eps8Grb7Cav2Foxo1Eps15Src


Description

No description

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117874view10:19, 23 May 2021EweitzModified title
82883view12:40, 11 November 2015JmeliusCorrect outdated id
71756view20:20, 17 October 2013MaintBotAutomated update of data sources
69206view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67178view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41396view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
35717view23:28, 12 February 2010AlexanderPico
35440view11:37, 12 February 2010MichielAdded ref
34429view23:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32711view22:49, 2 September 2009MaintBotReverted to version '11:32, 14 November 2008' by MaintBot
32710view22:45, 2 September 2009MaintBotadded xrefs
30821view23:58, 29 July 2009MaintBotConverted from Homo sapiens
21884view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:EGFR1 NetPath 4]] moved to [[Pathway:WP572]]: Moved to stable identifier
7998view13:46, 7 January 2008MaintBot[[Pathway:Mouse:EGFR1 NetPath 4]] moved to [[Pathway:Mus musculus:EGFR1 NetPath 4]]: Renaming species
7622view16:05, 18 December 2007MaintBotfixed category names
7216view12:33, 4 November 2007MaintBotAdded categories to GPML
6432view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:EGFR1_NetPath_4]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2900057D21RikGeneProduct72993 (Entrez Gene)
ABI1GeneProduct11308 (Entrez Gene)
ATF1GeneProduct11908 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Ap2a1GeneProduct11771 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene)
Arf4GeneProduct11843 (Entrez Gene)
Bcar1GeneProduct12927 (Entrez Gene)
Camk2aGeneProduct12322 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cav1GeneProduct12389 (Entrez Gene)
Cav2GeneProduct12390 (Entrez Gene)
CblGeneProduct12402 (Entrez Gene)
CblbGeneProduct208650 (Entrez Gene)
CblcGeneProduct80794 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Ceacam1GeneProduct26365 (Entrez Gene)
CebpaGeneProduct12606 (Entrez Gene)
CebpbGeneProduct12608 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
CskGeneProduct12988 (Entrez Gene)
Ctnnd1GeneProduct12388 (Entrez Gene)
Ddef1GeneProduct13196 (Entrez Gene)
Dip3bGeneProduct216190 (Entrez Gene)
Dnm1GeneProduct13429 (Entrez Gene)
Dok2GeneProduct13449 (Entrez Gene)
Dusp1GeneProduct19252 (Entrez Gene)
EPPK1GeneProduct223650 (Entrez Gene)
Eef1a1GeneProduct13627 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Elf3GeneProduct13710 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Elk4GeneProduct13714 (Entrez Gene)
Epn1GeneProduct13854 (Entrez Gene)
Eps15GeneProduct13858 (Entrez Gene)
Eps15l1GeneProduct13859 (Entrez Gene)
Eps8GeneProduct13860 (Entrez Gene)
Errfi1GeneProduct74155 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Git1GeneProduct216963 (Entrez Gene)
Gja1GeneProduct14609 (Entrez Gene)
Grb10GeneProduct14783 (Entrez Gene)
Grb14GeneProduct50915 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Grb7GeneProduct14786 (Entrez Gene)
Hat1GeneProduct107435 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
HdhGeneProduct15194 (Entrez Gene)
Hip1GeneProduct215114 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Inppl1GeneProduct16332 (Entrez Gene)
ItchGeneProduct16396 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Jund1GeneProduct16478 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
Krt1-17GeneProduct16667 (Entrez Gene)
Krt1-18GeneProduct16668 (Entrez Gene)
Krt2-7GeneProduct110310 (Entrez Gene)
Krt2-8GeneProduct16691 (Entrez Gene)
LOC382523GeneProduct382523 (Entrez Gene)
MAP3K1GeneProduct26401 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Map3k14GeneProduct53859 (Entrez Gene)
Map3k2GeneProduct26405 (Entrez Gene)
Map3k3GeneProduct26406 (Entrez Gene)
Map3k4GeneProduct26407 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mcf2GeneProduct109904 (Entrez Gene)
Mta2GeneProduct23942 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Nck1GeneProduct17973 (Entrez Gene)
Nck2GeneProduct17974 (Entrez Gene)
Ndufa13GeneProduct67184 (Entrez Gene)
NrasGeneProduct18176 (Entrez Gene)
PIK3R1GeneProduct18708 (Entrez Gene)
PRKCGGeneProduct
Pak1GeneProduct18479 (Entrez Gene)
Pebp1GeneProduct23980 (Entrez Gene)
Pik3c2bGeneProduct240752 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
PitpnaGeneProduct18738 (Entrez Gene)
Pkn2GeneProduct109333 (Entrez Gene)
Plcg1GeneProduct18803 (Entrez Gene)
Plcg2GeneProduct234779 (Entrez Gene)
Pld1GeneProduct18805 (Entrez Gene)
Pld2GeneProduct18806 (Entrez Gene)
Plec1GeneProduct18810 (Entrez Gene)
Plscr1GeneProduct22038 (Entrez Gene)
Prkar1aGeneProduct19084 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
Prkcb1GeneProduct18751 (Entrez Gene)
PrkciGeneProduct18759 (Entrez Gene)
PrkcmGeneProduct18760 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptk6GeneProduct20459 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Ptpn12GeneProduct19248 (Entrez Gene)
Ptpn5GeneProduct19259 (Entrez Gene)
Ptpn6GeneProduct15170 (Entrez Gene)
PtprrGeneProduct19279 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Rab5aGeneProduct271457 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RalbGeneProduct64143 (Entrez Gene)
Ralbp1GeneProduct19765 (Entrez Gene)
RalgdsGeneProduct19730 (Entrez Gene)
Rasa1GeneProduct218397 (Entrez Gene)
Rbbp7GeneProduct245688 (Entrez Gene)
Reps1GeneProduct19707 (Entrez Gene)
Reps2GeneProduct194590 (Entrez Gene)
RfxankGeneProduct19727 (Entrez Gene)
Rgs16GeneProduct19734 (Entrez Gene)
Ripk1GeneProduct19766 (Entrez Gene)
Rps6ka1GeneProduct20111 (Entrez Gene)
Rps6ka2GeneProduct20112 (Entrez Gene)
Rps6ka3GeneProduct110651 (Entrez Gene)
Rps6ka5GeneProduct73086 (Entrez Gene)
Sh2d3cGeneProduct27387 (Entrez Gene)
Sh3bgrlGeneProduct56726 (Entrez Gene)
Sh3gl2GeneProduct20404 (Entrez Gene)
Sh3gl3GeneProduct20408 (Entrez Gene)
Sh3kbp1GeneProduct58194 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Shoc2GeneProduct56392 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
SncaGeneProduct20617 (Entrez Gene)
Snrpd2GeneProduct107686 (Entrez Gene)
Socs1GeneProduct12703 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sos2GeneProduct20663 (Entrez Gene)
Sp1GeneProduct20683 (Entrez Gene)
Spry2GeneProduct24064 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat2GeneProduct20847 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Stxbp1GeneProduct20910 (Entrez Gene)
TgifGeneProduct21815 (Entrez Gene)
Tieg3GeneProduct194655 (Entrez Gene)
Tnip1GeneProduct57783 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
Usp6nlGeneProduct98910 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
Vav2GeneProduct22325 (Entrez Gene)
Vav3GeneProduct57257 (Entrez Gene)
WaslGeneProduct73178 (Entrez Gene)
Wnk1GeneProduct232341 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
Zfp259GeneProduct22687 (Entrez Gene)

Annotated Interactions

No annotated interactions
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