Calcium regulation in cardiac cells (Mus musculus)

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1Ca2+Protein Kinase CDAGgCalsequestrin S-CaGGNa+CaM kinaseP2+Cytosolic Ca2+PKA InhibitorsMembraneDepolarizationCalsequestrin C-CabgCaIP3PIP2IP4K+Ca2+GRKCytosolic CaK+2+Dihydropyridine-SensitiveM1 Muscarinic ReceptorCyclasesL-Type Ca2+ ChannelPKC inhibitor Protein-1bbgAdrenergic ReceptorFKBP12CaM kinaseK+Ca2+Epinephrine2+Regulators of G-proteinGap Junctions (Connexins)2+GG alpha i/o/zbgSignalingAdenylylADP + Piarrestin/GRKAdrenergic ReceptorcAMPPhopholambanNa+Calreticulin-CaPIP3 ReceptorsG alpha i/o/zarrestin/GRKIP3 ReceptorsRepolarizationGCalmodulin2+Na+/K+ ATPase2+b2+CaConnexinADP + PiNa+/Ca2+ Exchanger2+Protein Kinase AGNa2+2+CaCaAdenylyl CyclasesbSRCa2+Protein Kinase ACytosolic Ca2+ConnexinEpinephrineaCytosolbeta ArrestinCabPrkchRyr1Prkar1aGnai2Gnb1Atp1b2Gnao1PrkcdCasq1Gja5Cacna1eCamk2gGja8Adcy4Chrm1Kcnb1YwhahAtp1b1PrkcbGjb3Gm2423Itpr2Plcb3Atp2b3Rgs5PkiaCasq2Adra1aCalm1Cacnb3Gnb4Chrm3Rgs16Itpr3Prkar2aChrm2Adcy7YwhaeCamk4Atp1b3Adrb1Plcb3Camk1Fkbp1aRgs7Chrm4Camk2aAtp1a4ATPGnai3Gng8Gjd2Rgs1ADPGrk4SfnGrk5Fxyd2Ryr3Gja4Gjc1Rgs11Rgs3Slc8a1Gng4Rgs6Rgs2Gnb5Prkar1bAdra1bItpr1Gjb1Gngt1Kcnj5Gng2Gng12Gnai1GnaqGng11PrkchAdrb2Gng7Prkar2bPrkacbAdcy9Adcy8GnasRgs19Gng13PkibCacna1dArrb2Gjb4Gnb2Camk2dAnxa6YwhagGjb2PrkccSlc8a3YwhazPrkacaAdcy2Cacna1aRgs4Rgs14Camk2bPrkczPrkcaRgs18Rgs20Adcy3Chrm5Gjb5Adrb3GNG5ATPKcnj3GJA10Rgs10Adra1dGstt2Calm2Gja3ATPCacna1sPlnAdcy5PkigRyr2Calm3Cacna1cATPAtp2a2Arrb1Gnb3Gjc2AcetylcholineGjb6YwhabAdcy6Cacnb1Atp2b2PrkceAtp2a3PrkcqAdcy1GnazPrkd1Gng3Atp2b1CalrGja1Rgs17Rgs9Cacna1bGrk6Gna11


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r21808) with a 90% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117867view10:16, 23 May 2021EweitzModified title
107210view14:30, 17 September 2019MaintBotChEBI identifier normalization
106903view13:37, 17 September 2019MaintBotHMDB identifier normalization
95761view14:13, 19 January 2018MkutmonHomology conversion update
80276view19:11, 29 May 2015Siangyun.angAdded Atp1a1, Atp1a2
80275view18:30, 29 May 2015Siangyun.angUpdated identifier Kcnk3, Cacna1g, Cacna1h
80272view07:36, 29 May 2015Siangyun.angUpdated identifiers for Kcnk3, Cacna1g, Cacna1h, Atp2b4
80271view07:28, 29 May 2015Siangyun.angPeriodical save, work in progress
80270view07:26, 29 May 2015Siangyun.angAdded Cacna1g and Cacna1h
80269view06:55, 29 May 2015Siangyun.angAdded Kcnk3
80268view06:28, 29 May 2015Siangyun.angAdded Atp2b4
80267view22:14, 28 May 2015Siangyun.angUpdated Fxyd1 literature reference
80266view21:03, 28 May 2015Siangyun.angAdded Fxyd1
78150view08:26, 7 December 2014EgonwFixed the HMDB data source for a HMDB identifier.
73390view17:05, 25 January 2014EgonwFixed the HMDB database name.
69124view18:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67775view14:00, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
47774view05:39, 6 April 2012Khanspersupdated xref
41310view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
35443view11:40, 12 February 2010ThomasModified description
35442view11:39, 12 February 2010Thomasadded literature
34392view22:53, 9 December 2009MaintBotAutomatic update of empty xrefs
32841view20:32, 14 September 2009MaintBotadded xrefs
32464view17:27, 15 August 2009MaintBotFixed text labels
32147view14:00, 14 August 2009MaintBotFixed group labels
31475view21:21, 13 August 2009MaintBotFixed text labels
30879view00:16, 30 July 2009MaintBotConverted from Homo sapiens
21844view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Calcium regulation in cardiac cells]] moved to [[Pathway:WP553]]: Moved to stable identifier
7934view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Calcium regulation in cardiac cells]] moved to [[Pathway:Mus musculus:Calcium regulation in cardiac cells]]: Renaming species
7592view16:02, 18 December 2007MaintBotfixed category names
7459view12:42, 4 November 2007MaintBotAdded categories to GPML
19393view22:18, 22 May 2007N.Cottegpml file for [[Mouse:Calcium_regulation_in_cardiac_cells]]
19392view22:18, 22 May 2007J.Fonggpml file for [[Mouse:Calcium_regulation_in_cardiac_cells]]
6419view22:18, 22 May 2007Nsalomonisgpml file for [[Mouse:Calcium_regulation_in_cardiac_cells]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATPMetaboliteHMDB01532 (CAS)
ATPMetaboliteHMDB01532 (HMDB)
AcetylcholineMetaboliteHMDB00895 (HMDB)
Adcy1GeneProduct432530 (Entrez Gene) CYA1 HUMAN
Adcy2GeneProduct210044 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy3GeneProduct104111 (Entrez Gene)
Adcy4GeneProduct104110 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy5GeneProduct224129 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy6GeneProduct11512 (Entrez Gene)
Adcy7GeneProduct11513 (Entrez Gene)
Adcy8GeneProduct11514 (Entrez Gene)
Adcy9GeneProduct11515 (Entrez Gene)
Adra1aGeneProduct11549 (Entrez Gene)
Adra1bGeneProduct11548 (Entrez Gene)
Adra1dGeneProduct11550 (Entrez Gene)
Adrb1GeneProduct11554 (Entrez Gene)
Adrb2GeneProduct11555 (Entrez Gene)
Adrb3GeneProduct11556 (Entrez Gene)
Anxa6GeneProduct11749 (Entrez Gene)
Arrb1GeneProduct109689 (Entrez Gene)
Arrb2GeneProduct216869 (Entrez Gene)
Atp1a4GeneProduct27222 (Entrez Gene)
Atp1b1GeneProduct11931 (Entrez Gene)
Atp1b2GeneProduct11932 (Entrez Gene)
Atp1b3GeneProduct11933 (Entrez Gene)
Atp2a2GeneProduct11938 (Entrez Gene)
Atp2a3GeneProduct53313 (Entrez Gene)
Atp2b1GeneProduct67972 (Entrez Gene)
Atp2b2GeneProduct11941 (Entrez Gene)
Atp2b3GeneProduct320707 (Entrez Gene)
Cacna1aGeneProduct12286 (Entrez Gene)
Cacna1bGeneProduct12287 (Entrez Gene)
Cacna1cGeneProduct12288 (Entrez Gene)
Cacna1dGeneProduct12289 (Entrez Gene)
Cacna1eGeneProduct12290 (Entrez Gene)
Cacna1sGeneProduct12292 (Entrez Gene)
Cacnb1GeneProduct12295 (Entrez Gene)
Cacnb3GeneProduct12297 (Entrez Gene)
Calm1GeneProduct12313 (Entrez Gene)
Calm2GeneProduct12314 (Entrez Gene)
Calm3GeneProduct12315 (Entrez Gene)
CalrGeneProduct12317 (Entrez Gene)
Camk1GeneProduct52163 (Entrez Gene)
Camk2aGeneProduct12322 (Entrez Gene)
Camk2bGeneProduct12323 (Entrez Gene)
Camk2dGeneProduct108058 (Entrez Gene)
Camk2gGeneProduct12325 (Entrez Gene)
Camk4GeneProduct12326 (Entrez Gene)
Casq1GeneProduct12372 (Entrez Gene)
Casq2GeneProduct12373 (Entrez Gene)
Chrm1GeneProduct12669 (Entrez Gene)
Chrm2GeneProduct243764 (Entrez Gene)
Chrm3GeneProduct12671 (Entrez Gene)
Chrm4GeneProduct12672 (Entrez Gene)
Chrm5GeneProduct213788 (Entrez Gene)
Fkbp1aGeneProduct14225 (Entrez Gene)
Fxyd2GeneProduct11936 (Entrez Gene)
GJA10GeneProduct14610 (Entrez Gene)
GNG5GeneProduct14707 (Entrez Gene)
Gja1GeneProduct14609 (Entrez Gene)
Gja3GeneProduct14611 (Entrez Gene)
Gja4GeneProduct14612 (Entrez Gene)
Gja5GeneProduct14613 (Entrez Gene)
Gja8GeneProduct14616 (Entrez Gene)
Gjb1GeneProduct14618 (Entrez Gene)
Gjb2GeneProduct14619 (Entrez Gene)
Gjb3GeneProduct14620 (Entrez Gene)
Gjb4GeneProduct14621 (Entrez Gene)
Gjb5GeneProduct14622 (Entrez Gene)
Gjb6GeneProduct14623 (Entrez Gene)
Gjc1GeneProduct14615 (Entrez Gene)
Gjc2GeneProduct118454 (Entrez Gene)
Gjd2GeneProduct14617 (Entrez Gene)
Gm2423GeneProduct100039786 (Entrez Gene)
Gna11GeneProduct14672 (Entrez Gene)
Gnai1GeneProduct14677 (Entrez Gene)
Gnai2GeneProduct14678 (Entrez Gene)
Gnai3GeneProduct14679 (Entrez Gene)
Gnao1GeneProduct14681 (Entrez Gene)
GnaqGeneProduct14682 (Entrez Gene)
GnasGeneProduct14683 (Entrez Gene)
GnazGeneProduct14687 (Entrez Gene)
Gnb1GeneProduct14688 (Entrez Gene)
Gnb2GeneProduct14693 (Entrez Gene)
Gnb3GeneProduct14695 (Entrez Gene)
Gnb4GeneProduct14696 (Entrez Gene)
Gnb5GeneProduct14697 (Entrez Gene)
Gng11GeneProduct66066 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
Gng13GeneProduct64337 (Entrez Gene)
Gng2GeneProduct14702 (Entrez Gene)
Gng3GeneProduct14704 (Entrez Gene)
Gng4GeneProduct14706 (Entrez Gene)
Gng7GeneProduct14708 (Entrez Gene)
Gng8GeneProduct14709 (Entrez Gene)
Gngt1GeneProduct14699 (Entrez Gene)
Grk4GeneProduct14772 (Entrez Gene)
Grk5GeneProduct14773 (Entrez Gene)
Grk6GeneProduct26385 (Entrez Gene)
Gstt2GeneProduct14872 (Entrez Gene)
Itpr1GeneProduct16438 (Entrez Gene)
Itpr2GeneProduct16439 (Entrez Gene)
Itpr3GeneProduct16440 (Entrez Gene)
Kcnb1GeneProduct16500 (Entrez Gene)
Kcnj3GeneProduct16519 (Entrez Gene)
Kcnj5GeneProduct16521 (Entrez Gene)
PkiaGeneProduct18767 (Entrez Gene)
PkibGeneProduct18768 (Entrez Gene)
PkigGeneProduct18769 (Entrez Gene)
Plcb3GeneProduct18797 (Entrez Gene)
PlnGeneProduct18821 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkacbGeneProduct18749 (Entrez Gene)
Prkar1aGeneProduct19084 (Entrez Gene) KAP0 HUMAN
Prkar1bGeneProduct19085 (Entrez Gene)
Prkar2aGeneProduct19087 (Entrez Gene)
Prkar2bGeneProduct19088 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
PrkccGeneProduct18752 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PrkchGeneProduct18755 (Entrez Gene)
PrkcqGeneProduct18761 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Prkd1GeneProduct18760 (Entrez Gene) KPCM HUMAN
Rgs10GeneProduct67865 (Entrez Gene)
Rgs11GeneProduct50782 (Entrez Gene)
Rgs14GeneProduct51791 (Entrez Gene)
Rgs1GeneProduct50778 (Entrez Gene)
Rgs16GeneProduct19734 (Entrez Gene)
Rgs17GeneProduct56533 (Entrez Gene)
Rgs18GeneProduct64214 (Entrez Gene)
Rgs19GeneProduct56470 (Entrez Gene)
Rgs20GeneProduct58175 (Entrez Gene)
Rgs2GeneProduct19735 (Entrez Gene)
Rgs3GeneProduct50780 (Entrez Gene)
Rgs4GeneProduct19736 (Entrez Gene)
Rgs5GeneProduct19737 (Entrez Gene)
Rgs6GeneProduct50779 (Entrez Gene)
Rgs7GeneProduct24012 (Entrez Gene)
Rgs9GeneProduct19739 (Entrez Gene)
Ryr1GeneProduct20190 (Entrez Gene)
Ryr2GeneProduct20191 (Entrez Gene)
Ryr3GeneProduct20192 (Entrez Gene)
SfnGeneProduct55948 (Entrez Gene)
Slc8a1GeneProduct20541 (Entrez Gene)
Slc8a3GeneProduct110893 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
YwhaeGeneProduct22627 (Entrez Gene)
YwhagGeneProduct22628 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP553"
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