Calcium regulation in cardiac cells (Danio rerio)
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Thomas
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1
2+
Cytosolic Ca
Protein Kinase A
PIP2
G
2+
bg
b
P
CaM kinase
Ca
Ca
Epinephrine
beta Arrestin
Ca
Calsequestrin S-Ca
G alpha i/o/z
2+
DAG
SR
IP3 Receptors
K+
2+
Calreticulin-Ca
Calmodulin
ADP + Pi
Ca
Dihydropyridine-Sensitive
Membrane
Depolarization
b
Adenylyl
M1 Muscarinic Receptor
Adenylyl Cyclases
Adrenergic Receptor
IP3 Receptors
Cyclases
P
K+
G
IP3
b
Epinephrine
2+
bg
Ca
2+
bg
Protein Kinase C
PKC inhibitor Protein-1
G
Phopholamban
G alpha i/o/z
a
Ca2+
ADP + Pi
Na+
Calsequestrin C-Ca
FKBP12
Ca
K+
b
Connexin
Cytosolic Ca
g
PKA Inhibitors
Na+/Ca2+ Exchanger
Adrenergic Receptor
Ca
arrestin/GRK
2+
2+
Connexin
Cytosolic Ca2+
Na+/K+ ATPase
Cytosol
Signaling
Regulators of G-protein
Repolarization
2+
2+
2+
G
arrestin/GRK
GRK
Na+
cAMP
Na2+
2+
Ca
Gap Junctions (Connexins)
IP4
L-Type Ca2+ Channel
CaM kinase
Protein Kinase A
2+
G
LOC100003514
zgc:154027
zgc:153888
gnai3
LOC561288
ATP1B3
LOC564915
LOC557123
atp2a2a
tpte
CACNA1S
camk2d2
cx35
rgs20
chrm2a
gnai1
prkcb1
ATP1B2
YWHAQ
cx34.4
YWHAG
LOC568010
ARRB2
atp2b2
zgc:158799
gng3
LOC568726
ADRA1B
ryr3
cacnb1
GNB3
LOC100150701
RGS14
CALM3
CH73-270F14.2
CH211-220F13.4
chrm3
RGS2
YWHAZ
CACNB3
FXYD2
CH211-215F19.1
LOC100000320
camk4
PLN
PRKAR2B
chrm5a
LOC798222
ATP1B1
ATP
gnao1a
gng7
LOC557353
cx55.5
DKEYP-60A7.2
ATP
LOC567452
zgc:172124
PKIB
LOC792708
LOC100149388
GJA5
cx44.1
RGS10
RGS1
ATP1A4
GRK4
gng2
LOC569499
GNB4
PRKCQ
LOC568614
itpr2
LOC100150195
gnb5
LOC555284
gngt1
LOC795659
gnai2
anxa6
gng5
prkar2aa
LOC798498
YWHAB
rgs5
prkce
zgc:172124
ADCY6
SFN
gng12
CALM2
CACNA1E
arrb1
GJB5
GNB1
CAMK1
RYR2
ywhae1
cx35.4
LOC100149498
slc8a1b
LOC570659
RGS3
zgc:153624
CH211-238E12.1
rgs17
zgc:171922
CAMK2G
PRKCD
adcy2b
rgs6
ywhah
zgc:112145
cacna1c
cx33.8
ADRB2
zgc:92704
LOC571888
GJA12
zgc:73189
cx43
LOC564307
PKIG
GJA4
ADP
cacna1a
calrl2
LOC571825
PKIA
FKBP1A
zgc:101761
cacna1d
Acetylcholine
LOC568671
CALM1
gnb2
cx27.5
ATP
LOC100006640
plcb3
prkacb
atp2b3b
atp2b1a
prkcz
camk2a
rgs4
ADCY4
ATP
ADCY9
GNG11
slc8a3
casq2
cx48.5
zgc:110206
rgs7
adrb1
plcb3
RYR1
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP536(r21808)
with a 65% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
116853
view
10:48, 14 May 2021
Eweitz
Modified title
116852
view
10:47, 14 May 2021
Eweitz
Modified title
107098
view
14:18, 17 September 2019
MaintBot
ChEBI identifier normalization
106078
view
11:59, 16 August 2019
MaintBot
HMDB identifier normalization
95759
view
14:13, 19 January 2018
Mkutmon
Homology conversion update
71502
view
19:20, 17 October 2013
MaintBot
Automated update of data sources
68618
view
04:03, 6 July 2013
MaintBot
Updated to 2013 gpml schema
67772
view
13:56, 26 June 2013
Christine Chichester
Ontology Term : 'calcium/calcium-mediated signaling pathway' added !
47926
view
22:32, 18 April 2012
Khanspers
updated xref
40780
view
22:15, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35461
view
11:53, 12 February 2010
Thomas
Modified description
35456
view
11:52, 12 February 2010
Thomas
added literature
34171
view
21:18, 9 December 2009
MaintBot
Automatic update of empty xrefs
32335
view
13:30, 15 August 2009
MaintBot
Fixed text labels
31947
view
12:59, 14 August 2009
MaintBot
Fixed group labels
31377
view
20:39, 13 August 2009
MaintBot
Fixed text labels
31076
view
01:31, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ADCY4
GeneProduct
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6
GeneProduct
ADCY9
GeneProduct
ADP
Metabolite
ADRA1B
GeneProduct
ADRB2
GeneProduct
ARRB2
GeneProduct
ATP1A4
GeneProduct
ATP1B1
GeneProduct
ATP1B2
GeneProduct
ATP1B3
GeneProduct
ATP
Metabolite
Acetylcholine
Metabolite
CACNA1E
GeneProduct
CACNA1S
GeneProduct
405791 (Entrez Gene)
CACNB3
GeneProduct
CALM1
GeneProduct
CALM2
GeneProduct
CALM3
GeneProduct
CAMK1
GeneProduct
CAMK2G
GeneProduct
CH211-215F19.1
GeneProduct
558248 (Entrez Gene)
CH211-220F13.4
GeneProduct
100148976 (Entrez Gene)
CH211-238E12.1
GeneProduct
555941 (Entrez Gene)
CH73-270F14.2
GeneProduct
570108 (Entrez Gene)
DKEYP-60A7.2
GeneProduct
562619 (Entrez Gene)
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
FKBP1A
GeneProduct
FXYD2
GeneProduct
GJA12
GeneProduct
GJA4
GeneProduct
GJA5
GeneProduct
GJB5
GeneProduct
GNB1
GeneProduct
322104 (Entrez Gene)
GNB3
GeneProduct
406483 (Entrez Gene)
GNB4
GeneProduct
GNG11
GeneProduct
GRK4
GeneProduct
LOC100000320
GeneProduct
100000320 (Entrez Gene)
LOC100003514
GeneProduct
100003514 (Entrez Gene)
LOC100006640
GeneProduct
100006640 (Entrez Gene)
LOC100149388
GeneProduct
100149388 (Entrez Gene)
LOC100149498
GeneProduct
100149498 (Entrez Gene)
LOC100150195
GeneProduct
100150195 (Entrez Gene)
LOC100150701
GeneProduct
100150701 (Entrez Gene)
LOC555284
GeneProduct
555284 (Entrez Gene)
LOC557123
GeneProduct
557123 (Entrez Gene)
KPCM HUMAN
LOC557353
GeneProduct
557353 (Entrez Gene)
LOC561288
GeneProduct
561288 (Entrez Gene)
LOC564307
GeneProduct
564307 (Entrez Gene)
LOC564915
GeneProduct
564915 (Entrez Gene)
LOC567452
GeneProduct
567452 (Entrez Gene)
LOC568010
GeneProduct
568010 (Entrez Gene)
LOC568614
GeneProduct
568614 (Entrez Gene)
LOC568671
GeneProduct
568671 (Entrez Gene)
LOC568726
GeneProduct
568726 (Entrez Gene)
LOC569499
GeneProduct
569499 (Entrez Gene)
CYA1 HUMAN
LOC570659
GeneProduct
570659 (Entrez Gene)
LOC571825
GeneProduct
571825 (Entrez Gene)
LOC571888
GeneProduct
571888 (Entrez Gene)
LOC792708
GeneProduct
792708 (Entrez Gene)
LOC795659
GeneProduct
795659 (Entrez Gene)
LOC798222
GeneProduct
798222 (Entrez Gene)
LOC798498
GeneProduct
798498 (Entrez Gene)
PKIA
GeneProduct
PKIB
GeneProduct
797348 (Entrez Gene)
PKIG
GeneProduct
503808 (Entrez Gene)
PLN
GeneProduct
PRKAR2B
GeneProduct
PRKCD
GeneProduct
334571 (Entrez Gene)
PRKCQ
GeneProduct
555521 (Entrez Gene)
RGS1
GeneProduct
RGS10
GeneProduct
RGS14
GeneProduct
327368 (Entrez Gene)
RGS2
GeneProduct
436935 (Entrez Gene)
RGS3
GeneProduct
RYR1
GeneProduct
RYR2
GeneProduct
SFN
GeneProduct
YWHAB
GeneProduct
YWHAG
GeneProduct
YWHAQ
GeneProduct
YWHAZ
GeneProduct
PMID: 9861170 PMID: 1317796
adcy2b
GeneProduct
557902 (Entrez Gene)
There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
adrb1
GeneProduct
557194 (Entrez Gene)
anxa6
GeneProduct
353363 (Entrez Gene)
arrb1
GeneProduct
553266 (Entrez Gene)
atp2a2a
GeneProduct
393940 (Entrez Gene)
atp2b1a
GeneProduct
378746 (Entrez Gene)
atp2b2
GeneProduct
557430 (Entrez Gene)
atp2b3b
GeneProduct
558525 (Entrez Gene)
cacna1a
GeneProduct
562059 (Entrez Gene)
cacna1c
GeneProduct
170581 (Entrez Gene)
cacna1d
GeneProduct
403310 (Entrez Gene)
cacnb1
GeneProduct
436925 (Entrez Gene)
calrl2
GeneProduct
325317 (Entrez Gene)
camk2a
GeneProduct
550436 (Entrez Gene)
camk2d2
GeneProduct
436815 (Entrez Gene)
camk4
GeneProduct
550270 (Entrez Gene)
casq2
GeneProduct
114410 (Entrez Gene)
chrm2a
GeneProduct
352938 (Entrez Gene)
chrm3
GeneProduct
571679 (Entrez Gene)
chrm5a
GeneProduct
553978 (Entrez Gene)
cx27.5
GeneProduct
114405 (Entrez Gene)
cx33.8
GeneProduct
404725 (Entrez Gene)
cx34.4
GeneProduct
404727 (Entrez Gene)
cx35.4
GeneProduct
550380 (Entrez Gene)
cx35
GeneProduct
378444 (Entrez Gene)
cx43
GeneProduct
30236 (Entrez Gene)
cx44.1
GeneProduct
114403 (Entrez Gene)
cx48.5
GeneProduct
387533 (Entrez Gene)
cx55.5
GeneProduct
573483 (Entrez Gene)
gnai1
GeneProduct
393946 (Entrez Gene)
gnai2
GeneProduct
327650 (Entrez Gene)
gnai3
GeneProduct
100006888 (Entrez Gene)
gnao1a
GeneProduct
393760 (Entrez Gene)
gnb2
GeneProduct
541370 (Entrez Gene)
gnb5
GeneProduct
393719 (Entrez Gene)
gng12
GeneProduct
406604 (Entrez Gene)
gng2
GeneProduct
550256 (Entrez Gene)
gng3
GeneProduct
114462 (Entrez Gene)
gng5
GeneProduct
337838 (Entrez Gene)
gng7
GeneProduct
436670 (Entrez Gene)
gngt1
GeneProduct
335656 (Entrez Gene)
itpr2
GeneProduct
562585 (Entrez Gene)
plcb3
GeneProduct
100001532 (Entrez Gene)
prkacb
GeneProduct
563147 (Entrez Gene)
prkar2aa
GeneProduct
556042 (Entrez Gene)
prkcb1
GeneProduct
393953 (Entrez Gene)
prkce
GeneProduct
100005075 (Entrez Gene)
This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
prkcz
GeneProduct
555737 (Entrez Gene)
rgs17
GeneProduct
436796 (Entrez Gene)
rgs20
GeneProduct
436704 (Entrez Gene)
rgs4
GeneProduct
569876 (Entrez Gene)
rgs5
GeneProduct
573765 (Entrez Gene)
rgs6
GeneProduct
562667 (Entrez Gene)
rgs7
GeneProduct
436814 (Entrez Gene)
ryr3
GeneProduct
561350 (Entrez Gene)
slc8a1b
GeneProduct
797199 (Entrez Gene)
slc8a3
GeneProduct
560561 (Entrez Gene)
tpte
GeneProduct
327292 (Entrez Gene)
ywhae1
GeneProduct
322060 (Entrez Gene)
ywhah
GeneProduct
406443 (Entrez Gene)
zgc:101761
GeneProduct
493613 (Entrez Gene)
zgc:110206
GeneProduct
550519 (Entrez Gene)
zgc:112145
GeneProduct
550427 (Entrez Gene)
KAP0 HUMAN
zgc:153624
GeneProduct
767685 (Entrez Gene)
zgc:153888
GeneProduct
768164 (Entrez Gene)
zgc:154027
GeneProduct
767757 (Entrez Gene)
zgc:158799
GeneProduct
564064 (Entrez Gene)
zgc:171922
GeneProduct
559197 (Entrez Gene)
zgc:172124
GeneProduct
100144561 (Entrez Gene)
zgc:73189
GeneProduct
793087 (Entrez Gene)
zgc:92704
GeneProduct
436673 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
Ontology Terms
Bibliography
History
External references
DataNodes
Annotated Interactions
No annotated interactions