IL4 signaling (Homo sapiens)

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ReceptorDDCYECSumoylationCY -> PMGlycosylationDCY -> PMTranslocationMethylationCY -> PMRecruitmentCytoplasmGolgi apparatusDemethylationMolecular associationCY -> NUDEndosomeMolecule in the pathwayDDesumoylationDEnzyme complexENUbiquitination(Protein-protein interaction)DDephosphorylationPhosphorylationProteins in a complex interactionReaction through unknown mechanisms/moleculesExtracellularAccession Number: NetPath 16ControlMTNucleusPalmitoylationGOEndoplasmic reticulumMitochondrionDProteolytic cleavageERInhibitionAcetylationCY -> PMDeubiquitinationPMNUDPlasma membraneActivationLigandAutophosphorylationCY -> NUDeacetylationPRKCIJAK1RASA1PRKD3STAT6ELK1PRKCZNFKB1JAK1INPP5DMAPK11Gene SymbolPIK3R1IRS1IL13RA1DOK2MAPK1STAMSTAT6STAT1PRKD3EP300PRKCDJAK2PTPN6PRKCIPIK3CATYK2MAPK14IL4RBADADRBK2IL4RSTAT5ABCL2L1LCKMAPK3CXCR4JAK2NCF1MAPK14FYNIL4PIK3CDCREBBPSTAT6RELAPIK3R2SHC1SOCS3HMGA1SPI1ETS1GRB2FESATF2IRS2STAT6HIST2H3CRPS6KB1PLCG1PTPN11PRKCZSOCS1SRCCBLIL4PTK2PAWRSOS1JAK3PRKCDSOCS5NFKB1IL2RGAKT1STAT6


Description

Interleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 receptor alpha (IL4RA) and the common gamma chain (γc), Receptor complex 2 comprises of IL4RA and IL-13 receptor alpha1. IL-4 stimulates the JAK/STAT and MAPK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_16

Comments

GenMAPP notes 
NetPath 16 - IL-4 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129668view00:41, 22 May 2024EweitzModified title
126335view06:06, 22 April 2023EgonwLicense is CCZero
120704view13:21, 23 December 2021EweitzStandardize font, weight, case
116636view11:22, 9 May 2021EweitzModified title
116002view15:59, 28 March 2021EgonwCopied the NetPath paper to the literature list.
115983view18:11, 23 March 2021EgonwModified description
110790view17:32, 5 June 2020Joops05Modified title
108325view21:04, 6 December 2019L DupuisConverted interactions to graphical lines in legend
89828view12:06, 6 October 2016MkutmonModified description
79978view13:37, 29 April 2015Zarirepalced NEW ID for NCOA3
78576view14:50, 7 January 2015MaintBotadded missing graphIds
78053view13:03, 23 November 2014EgonwReplaced label Entrez Genes identifiers by their numeric IDs.
74009view15:25, 19 March 2014Joppe014connected lines
70016view01:50, 12 July 2013AlexanderPicoModified title
69985view21:32, 11 July 2013MaintBotupdated to 2013 schema
67378view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-4 signaling pathway' added !
63211view20:58, 8 May 2013MaintBotUpdating gpml version
48437view14:33, 24 May 2012NetPathModified description
45367view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45131view00:50, 7 October 2011AlexanderPicofixed db refs
44846view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44625view18:04, 22 September 2011Khanspersadded description
44624view18:03, 22 September 2011KhanspersUpdating content to NetSlim
44108view20:32, 24 August 2011KhanspersReverted to version '23:21, 1 March 2011' by Khanspers
44024view22:52, 22 August 2011KhanspersAdded category
44023view22:51, 22 August 2011KhanspersModified description
44022view22:49, 22 August 2011KhanspersUpdating pathway from NetSlim
41099view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35643view21:32, 12 February 2010KhanspersModified description
28126view19:19, 27 January 2009KhanspersCapitalized Pathway in name
21514view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
8176view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
7708view16:11, 18 December 2007MaintBotfixed category names
7247view12:41, 4 November 2007MaintBotAdded categories to GPML
6337view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-4_NetPath_16]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADRBK2GeneProduct157 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ETS1GeneProduct2113 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
Gene SymbolGeneProduct
HIST2H3CGeneProduct126961 (Entrez Gene)
HMGA1GeneProduct3159 (Entrez Gene)
IL13RA1GeneProduct3597 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL4RGeneProduct3566 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NCF1GeneProduct4687 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PAWRGeneProduct5074 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD3GeneProduct23683 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOCS5GeneProduct9655 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

No annotated interactions
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