Androgen receptor signaling pathway (Gallus gallus)

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1-7ERPlasma membraneEndosomeAndrogen IndependentDeubiquitinationPECPMTCY->NUAndrogen IndependentMolecule in the pathwayCY->NUGlycosylationPalmitoylationCY->NUProteolytic CleavageDAndrogen (T/DHT)DGene SymbolDPAutophosphorylationProteins in a complex interactionReactions through unknown mechanisms/moleculesEnzyme complexPCytoplasmPhosphorylationMethylationReceptor(Protein-protein interaction)ActivationTranslocationDeacetylationLigandAcetylationENDAccession Number: NetPath 2; cellmap:2InhibitionExtracellularUbiquitinationDephosphorylationDeSumoylationEndoplasmic reticulumSumoylationGOPRecruitmentNucleusMolecular associationDControlMitochondrionCY->NUCYGolgi appparatusDemethylationNUPMSRYRUNX1GHRESR1ARRAD54L2SMAD3CDK9APPL1UBE3AGTF2H1RASCAV1NCOA1TPTEHRMT1L2CREBBPEP300RCJMB04_13m17GTF2F1HMGB1CCNHARRB1CASP1CDC37UXTAKT1ARMAP2K1ESR2PA2G4PATZ1PXNNR2C2CTNNB1HTATIPGAPDHCCNE1NR5A1JUNPIAS4SLC25A4RB1FLNAHMGB2NCOA3TP53SVILPOU2F2NR0B2BAG1CCND1SP1CTDP1PNRC1EGFRHIPK3ARMMP1RCJMB04_19f10HRMT1L2CDK7GTF2F2COX5BPCAFNR0B1TGFB1I1SIN3ASRCPNRC1CDC2FHL2PIAS3NCOR2TMF1ETV5STUB1FLNANRIP1NSD1RANBP9ESR1NR3C1HDAC1HSPA1ARUNX2JUNNCOA4RNF14IGF1CALR3RCJMB04_24l12PTENTBPIPRELASTAT3RANP1BRCA1NR3C1POU2F1CASP3CASP7RCJMB04_19f10CDC25BRAC3CASP8PIAS1RNF4SENP1AKT1MAPK1UBE2IATF2TGIF1ARNCOA2SMAD4MDM2IL6IL6STSPDEFYWHAHAESPAK6RAF1PLAGL1MAPK1


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_2

Comments

GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP138(r20973) with a 78% conversion rate.

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Bibliography

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  1. Mooradian AD, Morley JE, Korenman SG; ''Biological actions of androgens.''; Endocr Rev, 1987 PubMed Europe PMC Scholia
  2. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B; ''Regulation of androgen action.''; Vitam Horm, 1999 PubMed Europe PMC Scholia
  3. Holterhus PM, Piefke S, Hiort O; ''Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs.''; J Steroid Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
  4. Davison SL, Bell R; ''Androgen physiology.''; Semin Reprod Med, 2006 PubMed Europe PMC Scholia
  5. Raudrant D, Rabe T; ''Progestogens with antiandrogenic properties.''; Drugs, 2003 PubMed Europe PMC Scholia
  6. Bardin CW, Brown T, Isomaa VV, Jänne OA; ''Progestins can mimic, inhibit and potentiate the actions of androgens.''; Pharmacol Ther, 1983 PubMed Europe PMC Scholia
  7. Heinlein CA, Chang C; ''The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117996view11:24, 23 May 2021EweitzModified title
82845view15:45, 6 November 2015Mkutmonupdated outdated identifiers
74403view08:49, 16 April 2014EgonwRemoved a data source where no ID was given.
73850view00:51, 26 February 2014MaintBotupdated schema
67046view09:59, 26 June 2013Christine ChichesterOntology Term : 'androgen signaling pathway' added !
47788view16:24, 6 April 2012Khanspersupdated xref
40973view22:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
35677view22:49, 12 February 2010AlexanderPico
35676view22:48, 12 February 2010AlexanderPicoadding description and refs
33898view17:59, 9 December 2009MaintBotAutomatic update of empty xrefs
31514view21:38, 13 August 2009MaintBotFixed text labels
30352view20:53, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AESGeneProduct
AKT1GeneProduct395928 (Entrez Gene)
APPL1GeneProduct416002 (Entrez Gene)
ARGeneProduct422165 (Entrez Gene)
ATF2GeneProduct395727 (Entrez Gene)
BAG1GeneProduct420967 (Entrez Gene)
BRCA1GeneProduct373983 (Entrez Gene)
CALR3GeneProduct420146 (Entrez Gene)
CASP1GeneProduct395764 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP8GeneProduct395284 (Entrez Gene)
CAV1GeneProduct373996 (Entrez Gene)
CCND1GeneProduct396341 (Entrez Gene)
CCNE1GeneProduct426117 (Entrez Gene)
CCNHGeneProduct427328 (Entrez Gene)
CDC2GeneProduct396252 (Entrez Gene)
CDC25BGeneProduct
CDC37GeneProduct395430 (Entrez Gene)
CDK7GeneProduct771294 (Entrez Gene)
CDK9GeneProduct417226 (Entrez Gene)
COX5BGeneProduct
CREBBPGeneProduct416667 (Entrez Gene)
CTDP1GeneProduct420813 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
ESR1GeneProduct396099 (Entrez Gene)
ESR2GeneProduct395575 (Entrez Gene)
ETV5GeneProduct395749 (Entrez Gene)
FHL2GeneProduct418726 (Entrez Gene)
FLNAGeneProduct
GAPDHGeneProduct374193 (Entrez Gene)
GHRGeneProduct408184 (Entrez Gene)
GTF2F1GeneProduct
GTF2F2GeneProduct418843 (Entrez Gene)
GTF2H1GeneProduct423081 (Entrez Gene)
HDAC1GeneProduct373961 (Entrez Gene)
HIPK3GeneProduct421597 (Entrez Gene)
HMGB1GeneProduct395724 (Entrez Gene)
HMGB2GeneProduct396482 (Entrez Gene)
HRMT1L2GeneProduct
HSPA1AGeneProduct
HTATIPGeneProduct
IGF1GeneProduct418090 (Entrez Gene)
IL6GeneProduct395337 (Entrez Gene)
IL6STGeneProduct395684 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MDM2GeneProduct395609 (Entrez Gene)
MMP1GeneProduct418982 (Entrez Gene)
NCOA1GeneProduct422016 (Entrez Gene)
NCOA2GeneProduct420176 (Entrez Gene)
NCOA3GeneProduct419208 (Entrez Gene)
NCOA4GeneProduct423615 (Entrez Gene)
NCOR2GeneProduct416815 (Entrez Gene)
NR0B1GeneProduct395285 (Entrez Gene)
NR0B2GeneProduct768353 (Entrez Gene)
NR2C2GeneProduct395253 (Entrez Gene)
NR3C1GeneProduct416343 (Entrez Gene)
NR5A1GeneProduct395960 (Entrez Gene)
NRIP1GeneProduct427966 (Entrez Gene)
NSD1GeneProduct416214 (Entrez Gene)
PA2G4GeneProduct425279 (Entrez Gene)
PAK6GeneProduct428837 (Entrez Gene)
PATZ1GeneProduct416963 (Entrez Gene)
PCAFGeneProduct428441 (Entrez Gene)
PIAS1GeneProduct427514 (Entrez Gene)
PIAS3GeneProduct
PIAS4GeneProduct420095 (Entrez Gene)
PLAGL1GeneProduct421664 (Entrez Gene)
PNRC1GeneProduct421817 (Entrez Gene)
POU2F1GeneProduct396463 (Entrez Gene)
POU2F2GeneProduct
PTENGeneProduct423675 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
RAC3GeneProduct395870 (Entrez Gene)
RAD54L2GeneProduct415933 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RANBP9GeneProduct420836 (Entrez Gene)
RANP1GeneProduct396193 (Entrez Gene)
RASGeneProduct
RB1GeneProduct386582 (Entrez Gene)
RCJMB04_13m17GeneProduct425530 (Entrez Gene)
RCJMB04_19f10GeneProduct771726 (Entrez Gene)
RCJMB04_24l12GeneProduct416383 (Entrez Gene)
RELAGeneProduct
RNF14GeneProduct416340 (Entrez Gene)
RNF4GeneProduct422886 (Entrez Gene)
RUNX1GeneProduct
RUNX2GeneProduct373919 (Entrez Gene)
SENP1GeneProduct426185 (Entrez Gene)
SIN3AGeneProduct415307 (Entrez Gene)
SLC25A4GeneProduct422546 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SMAD4GeneProduct
SP1GeneProduct395303 (Entrez Gene)
SPDEFGeneProduct428271 (Entrez Gene)
SRCGeneProduct396442 (Entrez Gene)
SRYGeneProduct
STAT3GeneProduct420027 (Entrez Gene)
STUB1GeneProduct426918 (Entrez Gene)
SVILGeneProduct420475 (Entrez Gene)
TBPIPGeneProduct
TGFB1I1GeneProduct
TGIF1GeneProduct396339 (Entrez Gene)
TMF1GeneProduct426072 (Entrez Gene)
TP53GeneProduct396200 (Entrez Gene)
TPTEGeneProduct418885 (Entrez Gene)
UBE2IGeneProduct374123 (Entrez Gene)
UBE3AGeneProduct418686 (Entrez Gene)
UXTGeneProduct
YWHAHGeneProduct416955 (Entrez Gene)

Annotated Interactions

No annotated interactions
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