The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module.
Source: http://www.netpath.org/pathways?path_id=NetPath_2
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GenMAPP notes
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
Mooradian AD, Morley JE, Korenman SG; ''Biological actions of androgens.''; Endocr Rev, 1987 PubMedEurope PMCScholia
Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B; ''Regulation of androgen action.''; Vitam Horm, 1999 PubMedEurope PMCScholia
Bardin CW, Brown T, Isomaa VV, Jänne OA; ''Progestins can mimic, inhibit and potentiate the actions of androgens.''; Pharmacol Ther, 1983 PubMedEurope PMCScholia
Heinlein CA, Chang C; ''The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.''; Mol Endocrinol, 2002 PubMedEurope PMCScholia
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