p38 MAPK signaling pathway (Gallus gallus)

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1-8FASL, InflammatoryCytokines, UV, etc.?Cytokines Production,Apoptosis, etc.Growth Factors, UVTrophic Factors, etc.??Stress: Osmotic shockg-radiation, AnisomycinDNA transcriptionRight click for commentsApoptosis??TranslationMAPKAPK2CREB1GRB2ELK1ATF2DAXXMAPK14RIPK1TRAF2TGFB2HRASPLA2G4ARAC1MKNK1MAP3K9MAP3K5SHC1MEF2DMAXTRADDMAPKAPK2CDC42RASGRF1MAPKAPK5HSPB1MAP3K7RCJMB04_17i9DDIT3MYCMAP3K1TGFBR1HMGN1RPS6KA5MAPK14MAP2K4MAP2K6


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP400(r21524) with a 80% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  2. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  3. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  4. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  6. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  7. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  8. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116822view10:16, 14 May 2021EweitzModified title
111169view13:37, 21 July 2020EgonwMade another pathway clickable
95745view13:50, 19 January 2018MkutmonHomology conversion update
95123view15:07, 16 November 2017Mkutmonadded missing homology converter comment source
68866view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67571view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41005view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
38244view21:22, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38243view21:21, 27 August 2010Khanspers
35706view23:14, 12 February 2010KhanspersDescription and bibliography
33926view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33479view15:07, 30 November 2009MaintBotRemoved group label
31529view21:43, 13 August 2009MaintBotFixed text labels
30372view20:59, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProduct395727 (Entrez Gene)
CDC42GeneProduct395917 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
DAXXGeneProduct
DDIT3GeneProduct
ELK1GeneProduct
GRB2GeneProduct386572 (Entrez Gene)
HMGN1GeneProduct395999 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
HSPB1GeneProduct396227 (Entrez Gene)
MAP2K4GeneProduct417312 (Entrez Gene)
MAP2K6GeneProduct
MAP3K1GeneProduct427144 (Entrez Gene)
MAP3K5GeneProduct421688 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAP3K9GeneProduct776822 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MAPKAPK5GeneProduct373929 (Entrez Gene)
MAXGeneProduct
MEF2DGeneProduct769067 (Entrez Gene)
MKNK1GeneProduct771961 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
PLA2G4AGeneProduct396394 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RASGRF1GeneProduct415578 (Entrez Gene) PDZ domain containing guanine nucleotide exchange
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RIPK1GeneProduct378921 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA5GeneProduct423408 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
TGFB2GeneProduct421352 (Entrez Gene)
TGFBR1GeneProduct374094 (Entrez Gene)
TRADDGeneProduct415700 (Entrez Gene)
TRAF2GeneProduct417287 (Entrez Gene)

Annotated Interactions

No annotated interactions
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