G1 to S cell cycle control (Bos taurus)

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1DNA replicationeRbDNA polymerasespG1/S transition CyclinDependent KinasesbpG2 Phase-M phaseE2fG1/S Cell CycleG1/S transition PhaseuinactiveCheckpointphosphorylation of proteinsinvolved in G1/S transitionupCell cycle DNA replication genespG1 CyclinDependant Cyclasescakpedp1G1 PhasepDegradationCyclin DsubTTTCC/GCGCCyclin Esorigin recognition complexPRIM2RPA2MCM3MCM6MYT1CCNB1CDC25ACCNHCdkWEE1ORC4LATF6BCdkPOLA2CDK4CREB3ORC2LTFDP1CDKORC1LPOLECDK2E2F3CCNE1CCND1E2F4TP53PCNARPA1CDKN2ACDK7CDK7MCM2CREB3L1CyclinDCDKN1BCCNE1CDK4MNAT1E2fCCNE1CDKN2DCDKN1CMCM7CDKN2CCCNA1GADD45AORC5LLOC615374RPA3CDC45LCDK6CDK6ORC3LRBL1CCND2RB1CCNE2LOC615374CDKN2BATMCREB1E2F1MCM4E2F5TFDP1MDM2RB1CDKMCM5CDKN1ACCNG2E2fORC6LCREB3L4E2F6PRIM1CREB3L3POLE2CCND3TFDP2TP53MYCE2F2RB1CyclinD


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP45(r20771) with a 83% conversion rate.

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Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95747view13:54, 19 January 2018MkutmonHomology conversion update
80826view15:27, 30 June 2015Mkutmonhomology conversion
67265view10:28, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63326view21:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
48129view05:48, 9 May 2012MaintBotUpdating from human to fix xref duplication
40507view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35825view21:59, 17 February 2010KhanspersAdded lit ref
35824view21:59, 17 February 2010KhanspersModified description
33750view23:58, 8 December 2009MaintBotAutomatic update of empty xrefs
32529view12:59, 17 August 2009MaintBotFixed text labels
32216view12:44, 15 August 2009MaintBotFixed text labels
31711view11:52, 14 August 2009MaintBotFixed group labels
31227view19:43, 13 August 2009MaintBotFixed text labels
30647view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF6BGeneProduct513928 (Entrez Gene)
ATMGeneProduct526824 (Entrez Gene)
CCNA1GeneProduct521939 (Entrez Gene)
CCNB1GeneProduct327679 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CCND2GeneProduct615414 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CCNE1GeneProduct533526 (Entrez Gene)
CCNE2GeneProduct538436 (Entrez Gene)
CCNG2GeneProduct512960 (Entrez Gene)
CCNHGeneProduct615512 (Entrez Gene)
CDC25AGeneProduct520188 (Entrez Gene)
CDC45LGeneProduct507122 (Entrez Gene)
CDKGeneProduct
CDK2GeneProduct519217 (Entrez Gene)
CDK4GeneProduct510618 (Entrez Gene)
CDK6GeneProduct511754 (Entrez Gene)
CDK7GeneProduct515462 (Entrez Gene)
CDKN1AGeneProduct513497 (Entrez Gene)
CDKN1BGeneProduct512613 (Entrez Gene)
CDKN1CGeneProduct510972 (Entrez Gene)
CDKN2AGeneProduct616369 (Entrez Gene)
CDKN2BGeneProduct527124 (Entrez Gene)
CDKN2CGeneProduct505691 (Entrez Gene)
CDKN2DGeneProduct510244 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CREB3GeneProduct281715 (Entrez Gene)
CREB3L1GeneProduct513105 (Entrez Gene)
CREB3L3GeneProduct513010 (Entrez Gene)
CREB3L4GeneProduct529566 (Entrez Gene)
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProduct535369 (Entrez Gene)
E2F2GeneProduct617024 (Entrez Gene)
E2F3GeneProduct541184 (Entrez Gene)
E2F4GeneProduct525428 (Entrez Gene)
E2F5GeneProduct539427 (Entrez Gene)
E2F6GeneProduct514085 (Entrez Gene)
E2fGeneProduct
GADD45AGeneProduct505463 (Entrez Gene)
LOC615374GeneProduct615374 (Entrez Gene)
MCM2GeneProduct510120 (Entrez Gene)
MCM3GeneProduct281302 (Entrez Gene)
MCM4GeneProduct504367 (Entrez Gene)
MCM5GeneProduct506970 (Entrez Gene)
MCM6GeneProduct517812 (Entrez Gene)
MCM7GeneProduct539924 (Entrez Gene)
MDM2GeneProduct540378 (Entrez Gene)
MNAT1GeneProduct534176 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
MYT1GeneProduct505552 (Entrez Gene)
ORC1LGeneProduct513523 (Entrez Gene)
ORC2LGeneProduct511281 (Entrez Gene)
ORC3LGeneProduct523714 (Entrez Gene)
ORC4LGeneProduct529245 (Entrez Gene)
ORC5LGeneProduct519409 (Entrez Gene)
ORC6LGeneProduct515476 (Entrez Gene)
PCNAGeneProduct515499 (Entrez Gene)
POLA2GeneProduct514793 (Entrez Gene)
POLEGeneProduct
POLE2GeneProduct518653 (Entrez Gene)
PRIM1GeneProduct506240 (Entrez Gene)
PRIM2GeneProduct514682 (Entrez Gene)
RB1GeneProduct534712 (Entrez Gene)
RBL1GeneProduct524870 (Entrez Gene)
RPA1GeneProduct504844 (Entrez Gene)
RPA2GeneProduct507912 (Entrez Gene)
RPA3GeneProduct512754 (Entrez Gene)
TFDP1GeneProduct534579 (Entrez Gene)
TFDP2GeneProduct506114 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
WEE1GeneProduct540322 (Entrez Gene)

Annotated Interactions

No annotated interactions
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