PI3K-AKT-NFkB pathway (Rattus norvegicus)

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Indirect inactivationCYTOKINESTRANSCRIPTION FACTORSHeat shockANTIGEN PROCESSINGSTRESS RESPONSE GENESDNAReactive oxygen speciesAPOPTOSISDirect inhibitionCELL ADHESION MOLECULESCELL MEMBRANEIndirect activationCYTOPLASMDirect activationGROWTH FACTORSProteosomal digestionANTI-APOPTOSISNUCLEAUSGlut2TirapHSPcJunELAM-1TraddAbca1c-FosBadCcl17IkkbNfkb1Pdpk1UbTapbpPdgfARipk1RelAVcamIrf1Birc2RelAPtk2IkkaPik3r1MycFox01BaxBmp3Glut1Tpl-2Erbb2Akt1HMOX1Traf2Irs2Ppp2caBmp2NfkbibRasGsk-3Pfkfb2Cfbcxcl2Irs1TNFNfkb2CflipSod1Traf6RantesIns1Ppp2r3aBcl2l1Bcl2l10EGFIgfbp2Nfkb1Tak1Akt2p53Tlr 4Myd88RelABirc3Gab2EgfrInsrIL-1 RNfkbiaFasIcam-1Irak4BaxMdm2Glut4NfkbieFth1RelBcl2RelATap1Bnip3Psmb9Bcl2A1Ppp2r5dTab1BimPik3caTnfr1aIkkgCXCL11Nfkb2UbSod2mTor


Description

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Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
126425view09:53, 28 April 2023EgonwLicense is CCZero
117958view10:52, 23 May 2021EweitzModified title
89860view12:28, 6 October 2016MkutmonModified description
87308view20:56, 20 July 2016EgonwAdded a bunch of Ensembl gene IDs.
87194view09:48, 19 July 2016EgonwAdded a bunch of Ensembl gene IDs.
87193view09:41, 19 July 2016EgonwModified title
83996view10:32, 9 January 2016EgonwAdded Ensembl identifiers (needs more)
83941view23:43, 4 January 2016MaintBotminor layout
71832view19:37, 18 October 2013MaintBotremoved data source from nodes without identifier
67596view11:31, 26 June 2013DdiglesOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
58950view18:19, 21 February 2013MaintBotUpdated Ensembl data source
41698view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
36258view20:01, 14 March 2010AlexanderPicoModified categories
36254view19:52, 14 March 2010AlexanderPicoConnected lines and created groups
36253view21:25, 13 March 2010CoolseenuModified description
36252view21:19, 13 March 2010CoolseenuNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abca1GeneProductabca1 (Ensembl)
Akt1GeneProduct24185 (Entrez Gene)
Akt2GeneProduct25233 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/64639?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
BaxGeneProductBax (Ensembl)
BaxGeneProductbax (Ensembl)
Bcl2A1GeneProductbcl2a1 (Ensembl)
Bcl2GeneProductbcl2a1 (Ensembl)
Bcl2l10GeneProduct114552 (Entrez Gene)
Bcl2l1GeneProduct24888 (Entrez Gene)
BimGeneProduct64547 (Entrez Gene)
Birc2GeneProductbirc2 (Ensembl)
Birc3GeneProduct78971 (Entrez Gene)
Bmp2GeneProductbmp2 (Ensembl)
Bmp3GeneProductbmp3 (Ensembl)
Bnip3GeneProductbnip3 (Ensembl)
CXCL11GeneProductcxcl11 (Ensembl)
Ccl17GeneProductccl17 (Ensembl)
CfbGeneProduct294257 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/294257?ordinalpos=6&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
CflipGeneProductcflar (Ensembl)
EGFGeneProductEGF (Ensembl)
ELAM-1GeneProduct25544 (Entrez Gene)
EgfrGeneProductegfr (Ensembl)
Erbb2GeneProducterbb2 (Ensembl)
FasGeneProduct246097 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/246097?ordinalpos=5&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Fox01GeneProduct84482 (Entrez Gene)
Fth1GeneProduct25319 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/25319?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVD
Gab2GeneProductgab2 (Ensembl)
Glut1GeneProductSLC2A3 (Ensembl)
Glut2GeneProductSLC2A2 (Ensembl)
Glut4GeneProduct25139 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/25139?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Gsk-3GeneProduct50686 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/50686?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
HMOX1GeneProductHMOX1 (Ensembl)
HSPGeneProduct
IL-1 RGeneProduct25663 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/25663?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Icam-1GeneProducticam1 (Ensembl)
Igfbp2GeneProductigfbp2 (Ensembl)
IkkaGeneProduct309361 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/309361?ordinalpos=4&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
IkkbGeneProduct84351 (Entrez Gene)
IkkgGeneProduct309295 (Entrez Gene)
Ins1GeneProductins1 (Ensembl)
InsrGeneProductinsr (Ensembl)
Irak4GeneProduct300177 (Entrez Gene)
Irf1GeneProduct24508 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/24508?ordinalpos=4&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Irs1GeneProduct25467 (Entrez Gene)
Irs2GeneProduct29376 (Entrez Gene)
Mdm2GeneProduct314856 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/314856?ordinalpos=5&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
MycGeneProductmyc (Ensembl)
Myd88GeneProductmyd88 (Ensembl) http://www.ncbi.nlm.nih.gov/gene/301059?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Nfkb1GeneProductNFKB1 (Ensembl)
Nfkb1GeneProductnfkb1 (Ensembl)
Nfkb2GeneProductNFKB2 (Ensembl)
Nfkb2GeneProductnfkb2 (Ensembl)
NfkbiaGeneProductnfkbia (Ensembl)
NfkbibGeneProductnfkbib (Ensembl)
NfkbieGeneProduct316241 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/316241?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
PdgfAGeneProduct25266 (Entrez Gene)
Pdpk1GeneProduct81745 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/81745?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Pfkfb2GeneProductpfkfb2 (Ensembl)
Pik3caGeneProduct170911 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Ppp2caGeneProductPPP2CA (Ensembl)
Ppp2r3aGeneProductPPP2R3A (Ensembl)
Ppp2r5dGeneProductPPP2R5D (Ensembl)
Psmb9GeneProductpsmb9 (Ensembl)
Ptk2GeneProductptk2 (Ensembl) http://www.ncbi.nlm.nih.gov/gene/5747?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
RantesGeneProduct81780 (Entrez Gene)
RasGeneProductKRAS (Ensembl)
RelGeneProduct305584 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/305584?ordinalpos=10&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.G
RelAGeneProductRELA (Ensembl)
RelAGeneProductrela (Ensembl)
Ripk1GeneProduct306886 (Entrez Gene)
Sod1GeneProductSOD1 (Ensembl)
Sod2GeneProductSOD2 (Ensembl)
TNFGeneProducttnf (Ensembl)
Tab1GeneProduct25663 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/315139?ordinalpos=5&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Tak1GeneProduct313121 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/313121?ordinalpos=8&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Tap1GeneProducttap1 (Ensembl)
TapbpGeneProduct25217 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/25217?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
TirapGeneProduct680127 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/680127?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Tlr 4GeneProduct29260 (Entrez Gene)
Tnfr1aGeneProduct25625 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/25625?ordinalpos=4&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Tpl-2GeneProduct116596 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/116596?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDo
TraddGeneProducttradd (Ensembl)
Traf2GeneProduct311786 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/311786?ordinalpos=4&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Traf6GeneProduct311245 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/311245?ordinalpos=4&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
UbGeneProductubc (Ensembl)
UbGeneProductubd (Ensembl)
VcamGeneProductvcam1 (Ensembl)
c-FosGeneProductfos (Ensembl)
cJunGeneProductjun (Ensembl)
cxcl2GeneProduct114105 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/114105?ordinalpos=3&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
mTorGeneProduct56718 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/56718?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Ge
p53GeneProduct24842 (Entrez Gene) http://www.ncbi.nlm.nih.gov/gene/24842?ordinalpos=9&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gen

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1491"
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