HG_Shared_Pathway-MYCN-CellCycle (Homo sapiens)

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1CENP-A/I/MCPCCentrosomeMotilityNucleusG1G2SMMembraneApoptosisMSX1TACC2TP53SURVIVINPIK3R1CDK4/6ESCO2RB1CCNB1/2BOREALINPPre-RCAURKBCDKN1A (p21)TCF4CCNA1/2CDKN1B (p27)PAKTCCNG2PHOX2BNOTCH3-ICASCL1CDCA3 (TOME1)CDK2CCNE1/2PPCDK2CDKN2A (p16)CCND1CDKN1C (p57)MYCNPFOXO3CDK1PHEY1PIK3CAFOXO3JAG1ALKDLL3NOTCH3


Description

Reflects the current status of research in the Human Genetics Department of the AMC in Amsterdam.

This is confidential. The pathway organizes results from wet lab experiments in the IMR32 neuroblastoma cell line.

Readouts are from Affymetrix array, western blot

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Ontology Terms

 

Bibliography


History

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CompareRevisionActionTimeUserComment
36582view11:37, 6 April 2010PietDeleted pathway: Temporary subselection
36518view13:04, 29 March 2010PietLaying out
36517view12:58, 29 March 2010PietColors
36516view12:56, 29 March 2010PietColors
36514view12:54, 29 March 2010PietNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKTGeneProduct208 (Entrez Gene)
ASCL1GeneProduct
AURKBGeneProduct
BOREALINGeneProduct
CCNA1/2GeneProduct
CCNB1/2GeneProduct
CCND1GeneProduct
CCNE1/2GeneProduct
CCNG2GeneProduct
CDCA3 (TOME1)GeneProduct
CDK1GeneProduct
CDK2GeneProduct1017 (Entrez Gene)
CDK4/6GeneProduct
CDKN1A (p21)GeneProduct
CDKN1B (p27)GeneProduct
CDKN1C (p57)GeneProduct1786 (Entrez Gene) 38 Genes additionally regulated
CDKN2A (p16)GeneProduct
ESCO2GeneProduct
FOXO3GeneProduct2309 (Entrez Gene)
HEY1GeneProduct
MSX1GeneProduct4487 (Entrez Gene)
MYCNGeneProduct4613 (Entrez Gene)
NOTCH3-ICGeneProduct4854 (Entrez Gene)
PMetabolite
PHOX2BGeneProduct8929 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene) Alias p110
PIK3R1GeneProduct5295 (Entrez Gene) Alias p85a
Pre-RCGeneProduct
RB1GeneProduct5925 (Entrez Gene)
SURVIVINGeneProduct
TACC2GeneProduct
TCF4GeneProduct
TP53GeneProduct

Annotated Interactions

No annotated interactions

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