Regulation of cardiac hypertrophy by miR-208 (Mus musculus)

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βMHCαMHC11121OverexpressionmiR-208bAtrial fibrilationsHypertrophyNucleusKnock-outmiR-208aProlonged PR interval, abberand conductionHopmiR-208amiR-208bCx40MyostatinβMHCGata4Trap1


Description

MicroRNA-208a regulates hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.

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Bibliography

  1. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ; ''MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.''; J Clin Invest, 2009 PubMed Europe PMC Scholia
  2. Lo CW; ''Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice.''; Circ Res, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126388view10:33, 26 April 2023EgonwLicense is CCZero
116841view10:31, 14 May 2021EweitzModified title
87631view08:54, 25 July 2016LindarieswijkOntology Term : 'hypertrophic cardiomyopathy pathway' added !
73503view23:11, 29 January 2014KhanspersModified title
69926view19:50, 11 July 2013Mkutmonfixed unconnected lines
69924view19:50, 11 July 2013MkutmonPeriodical save, work in progress
59045view20:46, 21 February 2013MaintBotUpdated Ensembl data source
41320view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
36815view08:12, 6 May 2010MLevelsModified categories
36798view11:58, 4 May 2010MLevelsMinor changes
36796view11:53, 4 May 2010SusanPeriodical save, work in progress
36791view10:22, 4 May 2010MLevelsModified description
36790view10:20, 4 May 2010MLevels
36789view10:20, 4 May 2010MLevelsMoved a line
36788view10:18, 4 May 2010MLevelsChanged Title
36787view10:15, 4 May 2010MLevelsModified description
36786view10:14, 4 May 2010MLevelsModified description
36785view10:09, 4 May 2010MLevelsMoving items
36784view10:07, 4 May 2010MLevelsPeriodical save, work in progress
36783view09:57, 4 May 2010MLevelsPeriodical save, work in progress
36782view09:37, 4 May 2010MLevelsPeriodical save, work in progress
36781view09:25, 4 May 2010MLevelsPeriodical save, work in progress
36780view09:06, 4 May 2010MLevelsMoving items
36778view08:56, 4 May 2010SusanSpecify description
36777view08:49, 4 May 2010SusanMinor adaptation
36755view08:19, 28 April 2010SusanPeriodical save, work in progress
36751view13:42, 27 April 2010MLevelsAdded color to the micro RNAs
36750view13:11, 27 April 2010MLevelsAdded Entrez Gene number for miR-208b
36749view09:18, 27 April 2010MLevelsMoved some items
36748view09:09, 27 April 2010MLevelsPathway Made
36747view09:02, 27 April 2010MLevelsPeriodical save, work in progress
36746view08:52, 27 April 2010MLevelsPeriodical save, work in progress
36745view08:42, 27 April 2010MLevelsPeriodical save, work in progress
36744view08:31, 27 April 2010MLevelsPeriodical save, work in progress
36742view08:21, 27 April 2010MLevelsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cx40Protein14613 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
HopGeneProduct74318 (Entrez Gene)
MyostatinProtein17700 (Entrez Gene)
Trap1Protein327987 (Entrez Gene)
miR-208aRnaMI0000555 (miRBase)
miR-208bRnaENSMUSG00000077928 (Ensembl Mouse) MI0005552
βMHCGeneProduct140781 (Entrez Gene)

Annotated Interactions

No annotated interactions

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