DNA damage response (Homo sapiens)

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Revision as of 10:30, 12 May 2010 by J.krumeich (Talk | contribs)
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14217221, 4, 5, 7, 9...1, 4, 5, 7, 9...21, 4, 5, 7, 9...38, 103102108, 1021731, 4, 5, 7, 9...8, 1028, 1021, 4, 5, 7, 9...6, 11, 12, 15, 18828, 101, 4, 5, 7, 9...141717101, 4, 5, 7, 9...222142G2/M transitionChromatinremodellingBlocked transcriptionGene productAlkylating agentsBulky DNA lesionDNA damage sourceCell membraneDouble-strand breaksSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingDNA repair and damage preventionMitochondrial membraneExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsCaption:MetaboliteReplication stressApoptosisCell-cycleChange in the Cell conditionTextDNA repairROSBlocked replicationDNA adductActivationMicro RNAG2/M checkpointG1/S transitionROSTextDifferent pathwayCellExtral cellularSpaceDNA damage ATM dependentCell survivalEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)G2/MCheckpointInhibitionSenescenceCell-cycle progressionChromatin alterationGADD45GCASP3ATRhsa-miR-29a/b/cFANCD2GADD45Bhsa-miR-21MRE11hsa-mir-21CDC25AE2F1CASP8RFChsa-miR-221CCND2TLK1CHEK2hsa-miR-106bhsa-mir-17PIDDhsa-mir-20aBAXCASP9hsa-mir-203RAD17RAD51hsa-miR-133aBIDTNFRSF10BCaffeinehsa-mir-195hsa-miR-24aHUS1PMAIP1CCNB1NBNBRCA1RB1CHEK1PRKDCCCNB3CCNB2CYCShsa-miR-421E2F1CDK4CREB1TLK2BBC3hsa-let-7bGADD45Bhsa-miR-17H2AFXRPA2SFNhsa-miR-145CCNE2FASRAD50CDK5SMC1Ahsa-mir-16hsa-miR-16hsa-let-7ahsa-mir-330CCND3ABL1hsa-mir-223CDK1c-MycGADD45ASESN1CDK6CDK2hsa-mir-424DDB2CDKN1Bhsa-miR-181aRRM2BPMLRAD1CDC25Chsa-miR-24hsa-miR-222CDKN1Ahsa-miR-24aTP53AIP1hsa-miR-34bRAD9Ahsa-miR-34cTP53hsa-mir-210hsa-mir-449aAPAF1ATMEstradiolATRIPCCNE1hsa-miR-449a/bhsa-miR-15aGADD45A7-hydroxystaurosporinehsa-miR-34CCND1RB1GADD45GRAD52


Description

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

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History

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CompareRevisionActionTimeUserComment
36878view13:08, 12 May 2010J.krumeichDeleted pathway: replaced
36872view12:08, 12 May 2010J.krumeichPeriodical save, work in progress
36869view11:58, 12 May 2010J.krumeichPeriodical save, work in progress
36868view11:37, 12 May 2010J.krumeichPeriodical save, work in progress
36867view10:50, 12 May 2010J.krumeichPeriodical save, work in progress
36866view10:30, 12 May 2010J.krumeichPeriodical save, work in progress
36865view10:19, 12 May 2010J.krumeichPeriodical save, work in progress
36864view10:09, 12 May 2010J.krumeichPeriodical save, work in progress
36862view09:48, 12 May 2010J.krumeichPeriodical save, work in progress
36861view09:35, 12 May 2010J.krumeichNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl Human)
APAF1GeneProductENSG00000120868 (Ensembl Human)
ATMGeneProductENSG00000149311 (Ensembl Human)
ATRGeneProductENSG00000175054 (Ensembl Human)
ATRIPGeneProduct84126 (Entrez Gene)
BAXGeneProductENSG00000087088 (Ensembl Human)
BBC3GeneProductENSG00000105327 (Ensembl Human)
BIDGeneProductENSG00000015475 (Ensembl Human)
BRCA1GeneProductENSG00000012048 (Ensembl Human)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CCNB1GeneProductENSG00000134057 (Ensembl Human)
CCNB2GeneProductENSG00000157456 (Ensembl Human)
CCNB3GeneProductENSG00000147082 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCND2GeneProductENSG00000118971 (Ensembl Human)
CCND3GeneProductENSG00000112576 (Ensembl Human)
CCNE1GeneProductENSG00000105173 (Ensembl Human)
CCNE2GeneProductENSG00000175305 (Ensembl Human)
CDC25AGeneProductENSG00000164045 (Ensembl Human)
CDC25CGeneProductENSG00000158402 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CDK5GeneProductENSG00000164885 (Ensembl Human)
CDK6GeneProductENSG00000105810 (Ensembl Human)
CDKN1AGeneProductENSG00000124762 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CHEK1GeneProductENSG00000149554 (Ensembl Human)
CHEK2GeneProductENSG00000183765 (Ensembl Human)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl Human)
CaffeineMetabolite2424 (Chemspider)
DDB2GeneProductENSG00000134574 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl Human)
FASGeneProductENSG00000026103 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GADD45GGeneProductENSG00000130222 (Ensembl Human)
H2AFXGeneProductENSG00000188486 (Ensembl Human)
HUS1GeneProductENSG00000188996 (Ensembl Human)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl Human)
PMLGeneProductENSG00000140464 (Ensembl Human)
PRKDCGeneProductENSG00000121031 (Ensembl Human)
RAD17GeneProductENSG00000152942 (Ensembl Human)
RAD1GeneProductENSG00000113456 (Ensembl Human)
RAD50GeneProductENSG00000113522 (Ensembl Human)
RAD51GeneProductENSG00000051180 (Ensembl Human)
RAD52GeneProductENSG00000002016 (Ensembl Human)
RAD9AGeneProductENSG00000172613 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl Human)
RRM2BGeneProductENSG00000048392 (Ensembl Human)
SESN1GeneProductENSG00000080546 (Ensembl Human)
SFNGeneProductENSG00000175793 (Ensembl Human)
SMC1AGeneProductENSG00000072501 (Ensembl Human)
TLK1GeneProductENSG00000198586 (Ensembl Human)
TLK2GeneProductENSG00000146872 (Ensembl Human)
TNFRSF10BGeneProductENSG00000120889 (Ensembl Human)
TP53AIP1GeneProductENSG00000120471 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
c-MycGeneProduct4609 (Entrez Gene)
hsa-let-7aRna
hsa-let-7bRnaENSG00000207875 (Ensembl Human)
hsa-miR-106bRna
hsa-miR-133aRna
hsa-miR-145Rna
hsa-miR-15aRna
hsa-miR-16Rna
hsa-miR-17Rna
hsa-miR-181aRna
hsa-miR-21Rna
hsa-miR-221Rna
hsa-miR-222Rna
hsa-miR-24GeneProduct
hsa-miR-24aRna
hsa-miR-29a/b/cRna
hsa-miR-34Rna
hsa-miR-34bRna
hsa-miR-34cRna
hsa-miR-421Rna
hsa-miR-449a/bRna
hsa-mir-16RnaENSG00000208006 (Ensembl Human)
hsa-mir-17GeneProductENSG00000207745 (Ensembl Human)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
hsa-mir-203GeneProductENSG00000207568 (Ensembl Human)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl Human)
hsa-mir-210GeneProductENSG00000199038 (Ensembl Human)
hsa-mir-21GeneProductENSG00000199004 (Ensembl Human)
hsa-mir-223GeneProductENSG00000207939 (Ensembl Human)
hsa-mir-330GeneProductENSG00000199066 (Ensembl Human)
hsa-mir-424RnaENSG00000199097 (Ensembl Human)
hsa-mir-449aRnaENSG00000198983 (Ensembl Human)

Annotated Interactions

No annotated interactions

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