DNA damage response (Homo sapiens)

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Revision as of 11:37, 12 May 2010 by J.krumeich (Talk | contribs)
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7101021010104, 6, 8, 9, 13...32103, 154, 6, 8, 9, 13...74, 6, 8, 9, 13...3102103, 154, 6, 8, 9, 13...3, 154, 6, 8, 9, 13...1110103, 1510154, 6, 8, 9, 13...4, 6, 8, 9, 13...101131011273, 151, 5, 6, 12, 14DNA adductCell-cycle progressionROSSenescenceChromatin alterationSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingActivationBlocked transcriptionTextCell-cycleG2/M transitionCellMitochondrial membraneApoptosisExtral cellularSpaceDouble-strand breaksBulky DNA lesionG1/S transitionDNA damage sourceMetaboliteTextROSGene productG2/M checkpointChromatinremodellingDNA damage ATM dependentInhibitionChange in the Cell conditionExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsDNA repair and damage preventionBlocked replicationCaption:Different pathwayCell survivalEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)Alkylating agentsDNA repairG2/MCheckpointMicro RNACell membraneReplication stressCDKN1ARRM2Bhsa-miR-24aRFChsa-mir-221DDB2PMLPMAIP1hsa-miR-145CYCSCHEK1FANCD2hsa-mir-20aTP53BBC3hsa-mir-16RAD1CDK5CCNB2TP53AIP1APAF1hsa-mir-16TLK1GADD45Ghsa-mir-330CCND1NBNCDK4hsa-mir-210PIDDhsa-miR-21RAD50ATMRAD17PRKDCCCNB1GADD45Ahsa-miR-34bEstradiolBIDCASP3RAD9Ahsa-let-7bRPA2CCND3hsa-miR-34chsa-miR-34CDC25AGADD45Ghsa-mir-203CDK1hsa-mir-449aATRIPCHEK2RB1hsa-miR-24aE2F1BAXCASP8FASRAD52hsa-mir-181ahsa-miR-106bhsa-miR-24RAD51CCNE1HUS1ABL1RB1hsa-miR-15aSFNCCND2Caffeinec-Mychsa-mir-21CCNE2hsa-miR-16SMC1Ahsa-mir-223CCNB3BRCA1MRE11CDK6hsa-mir-133ahsa-mir-17hsa-mir-29aCDKN1Bhsa-miR-421ATRhsa-miR-17GADD45BTNFRSF10B7-hydroxystaurosporineGADD45ACDK2SESN1CDC25CE2F1hsa-mir-29chsa-let-7ahsa-mir-424hsa-mir-222CREB1hsa-mir-195CASP9hsa-miR-449a/bTLK2GADD45Bhsa-mir-29bH2AFX


Description

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

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Bibliography


History

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CompareRevisionActionTimeUserComment
36878view13:08, 12 May 2010J.krumeichDeleted pathway: replaced
36872view12:08, 12 May 2010J.krumeichPeriodical save, work in progress
36869view11:58, 12 May 2010J.krumeichPeriodical save, work in progress
36868view11:37, 12 May 2010J.krumeichPeriodical save, work in progress
36867view10:50, 12 May 2010J.krumeichPeriodical save, work in progress
36866view10:30, 12 May 2010J.krumeichPeriodical save, work in progress
36865view10:19, 12 May 2010J.krumeichPeriodical save, work in progress
36864view10:09, 12 May 2010J.krumeichPeriodical save, work in progress
36862view09:48, 12 May 2010J.krumeichPeriodical save, work in progress
36861view09:35, 12 May 2010J.krumeichNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl Human)
APAF1GeneProductENSG00000120868 (Ensembl Human)
ATMGeneProductENSG00000149311 (Ensembl Human)
ATRGeneProductENSG00000175054 (Ensembl Human)
ATRIPGeneProduct84126 (Entrez Gene)
BAXGeneProductENSG00000087088 (Ensembl Human)
BBC3GeneProductENSG00000105327 (Ensembl Human)
BIDGeneProductENSG00000015475 (Ensembl Human)
BRCA1GeneProductENSG00000012048 (Ensembl Human)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CCNB1GeneProductENSG00000134057 (Ensembl Human)
CCNB2GeneProductENSG00000157456 (Ensembl Human)
CCNB3GeneProductENSG00000147082 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCND2GeneProductENSG00000118971 (Ensembl Human)
CCND3GeneProductENSG00000112576 (Ensembl Human)
CCNE1GeneProductENSG00000105173 (Ensembl Human)
CCNE2GeneProductENSG00000175305 (Ensembl Human)
CDC25AGeneProductENSG00000164045 (Ensembl Human)
CDC25CGeneProductENSG00000158402 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CDK5GeneProductENSG00000164885 (Ensembl Human)
CDK6GeneProductENSG00000105810 (Ensembl Human)
CDKN1AGeneProductENSG00000124762 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CHEK1GeneProductENSG00000149554 (Ensembl Human)
CHEK2GeneProductENSG00000183765 (Ensembl Human)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl Human)
CaffeineMetabolite2424 (Chemspider)
DDB2GeneProductENSG00000134574 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl Human)
FASGeneProductENSG00000026103 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GADD45GGeneProductENSG00000130222 (Ensembl Human)
H2AFXGeneProductENSG00000188486 (Ensembl Human)
HUS1GeneProductENSG00000188996 (Ensembl Human)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl Human)
PMLGeneProductENSG00000140464 (Ensembl Human)
PRKDCGeneProductENSG00000121031 (Ensembl Human)
RAD17GeneProductENSG00000152942 (Ensembl Human)
RAD1GeneProductENSG00000113456 (Ensembl Human)
RAD50GeneProductENSG00000113522 (Ensembl Human)
RAD51GeneProductENSG00000051180 (Ensembl Human)
RAD52GeneProductENSG00000002016 (Ensembl Human)
RAD9AGeneProductENSG00000172613 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl Human)
RRM2BGeneProductENSG00000048392 (Ensembl Human)
SESN1GeneProductENSG00000080546 (Ensembl Human)
SFNGeneProductENSG00000175793 (Ensembl Human)
SMC1AGeneProductENSG00000072501 (Ensembl Human)
TLK1GeneProductENSG00000198586 (Ensembl Human)
TLK2GeneProductENSG00000146872 (Ensembl Human)
TNFRSF10BGeneProductENSG00000120889 (Ensembl Human)
TP53AIP1GeneProductENSG00000120471 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
c-MycGeneProduct4609 (Entrez Gene)
hsa-let-7aRna
hsa-let-7bRnaENSG00000207875 (Ensembl Human)
hsa-miR-106bRna
hsa-miR-145Rna
hsa-miR-15aRna
hsa-miR-16Rna
hsa-miR-17Rna
hsa-miR-21Rna
hsa-miR-24GeneProduct
hsa-miR-24aRna
hsa-miR-34Rna
hsa-miR-34bRna
hsa-miR-34cRna
hsa-miR-421Rna
hsa-miR-449a/bRna
hsa-mir-133aRnaENSG00000207786 (Ensembl Human)
hsa-mir-16RnaENSG00000208006 (Ensembl Human)
hsa-mir-17GeneProductENSG00000207745 (Ensembl Human)
hsa-mir-181aRnaENSG00000207759 (Ensembl Human)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
hsa-mir-203GeneProductENSG00000207568 (Ensembl Human)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl Human)
hsa-mir-210GeneProductENSG00000199038 (Ensembl Human)
hsa-mir-21GeneProductENSG00000199004 (Ensembl Human)
hsa-mir-221RnaENSG00000207870 (Ensembl Human)
hsa-mir-222RnaENSG00000207725 (Ensembl Human)
hsa-mir-223GeneProductENSG00000207939 (Ensembl Human)
hsa-mir-29aRnaENSG00000198981 (Ensembl Human)
hsa-mir-29bRnaENSG00000207748 (Ensembl Human)
hsa-mir-29cRnaENSG00000207966 (Ensembl Human)
hsa-mir-330GeneProductENSG00000199066 (Ensembl Human)
hsa-mir-424RnaENSG00000199097 (Ensembl Human)
hsa-mir-449aRnaENSG00000198983 (Ensembl Human)

Annotated Interactions

No annotated interactions

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