miRNA regulation of DNA damage response (Homo sapiens)

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1811119, 161, 6-8, 13...1, 6-8, 13...2411115112119, 161, 6-8, 13...181, 6-8, 13...418959, 16115113, 10, 12, 15, 17111, 6-8, 13...1141116169, 161141, 6-8, 13...9, 1616111, 6-8, 13...ApoptosisGene productDNA adductBlocked replicationDNA repair and damage preventionG2/MCheckpointTextCellCell-cycleSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingBlocked transcriptionG1/S transitionCell survivalCell membraneDifferent pathwayG2/M transitionROSCell-cycle progressionChange in the Cell conditionAlkylating agentsG2/M checkpointDNA damage sourceExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsCaption:MetaboliteMitochondrial membraneDNA damage ATM dependentChromatinremodellingInhibitionBulky DNA lesionSenescenceMicro RNAEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)ROSTextReplication stressDouble-strand breaksChromatin alterationDNA repairActivationExtral cellularSpaceTLK2hsa-mir-21SMC1ATNFRSF10Bhsa-mir-17SFNCCNE1hsa-mir-373FANCD2hsa-mir-17GADD45Bhsa-mir-21hsa-mir-29chsa-mir-106bGADD45Ahsa-mir-424PMAIP1CHEK2hsa-mir-24BIDCDKN1Ahsa-mir-16hsa-mir-16CASP3CDK2TLK1CREB1CCNB2CCND3RPA2RAD1hsa-mir-133aCaffeinehsa-mir-15ahsa-mir-195hsa-mir-16ATRRAD9ABBC3hsa-mir-449bCASP9PRKDCPIDDCCND2CCNB1RRM2BMRE11RB1GADD45ACASP8CCNE2hsa-let-7a-1TP53AIP1PMLRAD51GADD45Ghsa-mir-449aHUS17-hydroxystaurosporineGADD45Ghsa-mir-34cABL1hsa-mir-222GADD45BDDB2CYCShsa-mir-221CDKN1BATRIPE2F1hsa-mir-203NBNhsa-mir-181aCDK5ATMFASH2AFXhsa-mir-210CDC25Chsa-mir-421RAD52CCNB3SESN1RAD50CDK1RB1hsa-mir-34bCHEK1hsa-mir-145c-MycEstradiolTP53CCND1BAXCDK4hsa-mir-29aE2F1hsa-mir-330APAF1CDK6RAD17hsa-mir-20aGeneProductBRCA1hsa-mir-29bCDC25Ahsa-mir-223hsa-mir-449aRFC


Description

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
126392view15:22, 26 April 2023EgonwLicense is CCZero
124175view12:54, 23 September 2022VanessaSousaAKT1 gene involved in miRNA regulation of DNA damage response
118120view11:08, 24 May 2021EweitzModified description
116539view12:09, 7 May 2021EweitzModified title
113793view09:04, 24 November 2020Finterlysmall graphical update
107119view14:19, 17 September 2019MaintBotChEBI identifier normalization
105862view23:21, 15 August 2019KhanspersModified description
103023view15:52, 31 January 2019Mkutmonupdated ensembl ids
102986view12:46, 31 January 2019SusanRe-annotated microRNAs
98336view13:26, 23 August 2018EgonwUpdated the MIR21 identifier.
94738view15:05, 5 October 2017Ryanmillerconnected lines
84694view21:01, 15 March 2016KhanspersQuick edit to datanode annotation or property
79564view17:47, 25 March 2015Zarichanged ID for PRKDC
78503view10:29, 7 January 2015MaintBotadded missing graphIds
75268view21:48, 13 May 2014Khanspersupdated miRNAs and lines
71711view20:03, 17 October 2013MaintBotremoved data source from nodes without identifier
70992view21:04, 21 September 2013EgonwAdded the missing DB names.
70112view19:09, 12 July 2013MaintBotupdated to 2013 schema
70023view01:52, 12 July 2013AlexanderPicoModified title
68400view08:12, 5 July 2013EgonwConverted the "alkylating agent" label into a DataNode with ChEBI identifier.
59081view21:57, 21 February 2013MaintBotUpdated Ensembl data source
45379view21:45, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44908view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41096view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
40043view15:20, 1 February 2011AndraPeriodical save, work in progress
39801view15:52, 20 January 2011Stan.gaj
39800view15:51, 20 January 2011Stan.gaj
39799view15:48, 20 January 2011Stan.gaj
39717view11:00, 14 January 2011Stan.gaj
38644view12:16, 23 September 2010Mkutmonadded some pathway links
38435view08:40, 13 September 2010Stan.gajAdded miRNA-122/Cyclin G1/MDM2/p53 regulatory network
38434view08:10, 13 September 2010Stan.gajSpecify description
38432view08:00, 13 September 2010Stan.gajPeriodical save, work in progress
37425view15:16, 1 June 2010J.krumeichSpecify description
37424view15:14, 1 June 2010J.krumeichSpecify description
37423view15:04, 1 June 2010J.krumeichPeriodical save, work in progress
37422view14:34, 1 June 2010J.krumeichPeriodical save, work in progress
37296view09:18, 25 May 2010J.krumeichPeriodical save, work in progress
37195view09:25, 21 May 2010J.krumeichPeriodical save, work in progress
37189view11:30, 20 May 2010J.krumeichModified description
37188view11:23, 20 May 2010J.krumeichPeriodical save, work in progress
37187view11:12, 20 May 2010J.krumeichPeriodical save, work in progress
37186view10:02, 20 May 2010J.krumeichSpecify description
37185view09:59, 20 May 2010J.krumeichPeriodical save, work in progress
37184view09:49, 20 May 2010J.krumeichPeriodical save, work in progress
37183view09:39, 20 May 2010J.krumeichPeriodical save, work in progress
37182view09:23, 20 May 2010J.krumeichSpecify description
37181view09:22, 20 May 2010J.krumeichSpecify description
37180view09:18, 20 May 2010J.krumeichPeriodical save, work in progress
37179view09:08, 20 May 2010J.krumeichPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl Human)
APAF1GeneProductENSG00000120868 (Ensembl Human)
ATMGeneProductENSG00000149311 (Ensembl Human)
ATRGeneProductENSG00000175054 (Ensembl Human)
ATRIPGeneProduct84126 (Entrez Gene)
BAXGeneProductENSG00000087088 (Ensembl Human)
BBC3GeneProductENSG00000105327 (Ensembl Human)
BIDGeneProductENSG00000015475 (Ensembl Human)
BRCA1GeneProductENSG00000012048 (Ensembl Human)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CCNB1GeneProductENSG00000134057 (Ensembl Human)
CCNB2GeneProductENSG00000157456 (Ensembl Human)
CCNB3GeneProductENSG00000147082 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCND2GeneProductENSG00000118971 (Ensembl Human)
CCND3GeneProductENSG00000112576 (Ensembl Human)
CCNE1GeneProductENSG00000105173 (Ensembl Human)
CCNE2GeneProductENSG00000175305 (Ensembl Human)
CDC25AGeneProductENSG00000164045 (Ensembl Human)
CDC25CGeneProductENSG00000158402 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CDK5GeneProductENSG00000164885 (Ensembl Human)
CDK6GeneProductENSG00000105810 (Ensembl Human)
CDKN1AGeneProductENSG00000124762 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CHEK1GeneProductENSG00000149554 (Ensembl Human)
CHEK2GeneProductENSG00000183765 (Ensembl Human)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl Human)
CaffeineMetabolite2424 (Chemspider)
DDB2GeneProductENSG00000134574 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl Human)
FASGeneProductENSG00000026103 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GADD45GGeneProductENSG00000130222 (Ensembl Human)
GeneProductGeneProduct
H2AFXGeneProductENSG00000188486 (Ensembl Human)
HUS1GeneProductENSG00000188996 (Ensembl Human)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl Human)
PMLGeneProductENSG00000140464 (Ensembl Human)
PRKDCGeneProductENSG00000121031 (Ensembl Human)
RAD17GeneProductENSG00000152942 (Ensembl Human)
RAD1GeneProductENSG00000113456 (Ensembl Human)
RAD50GeneProductENSG00000113522 (Ensembl Human)
RAD51GeneProductENSG00000051180 (Ensembl Human)
RAD52GeneProductENSG00000002016 (Ensembl Human)
RAD9AGeneProductENSG00000172613 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl Human)
RRM2BGeneProductENSG00000048392 (Ensembl Human)
SESN1GeneProductENSG00000080546 (Ensembl Human)
SFNGeneProductENSG00000175793 (Ensembl Human)
SMC1AGeneProductENSG00000072501 (Ensembl Human)
TLK1GeneProductENSG00000198586 (Ensembl Human)
TLK2GeneProductENSG00000146872 (Ensembl Human)
TNFRSF10BGeneProductENSG00000120889 (Ensembl Human)
TP53AIP1GeneProductENSG00000120471 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
c-MycGeneProduct4609 (Entrez Gene)
hsa-let-7a-1RnaENSG00000199165 (Ensembl Human)
hsa-mir-106bRnaENSG00000208036 (Ensembl Human)
hsa-mir-133aRnaENSG00000207786 (Ensembl Human)
hsa-mir-145RnaENSG00000207700 (Ensembl Human)
hsa-mir-15aRnaENSG00000207718 (Ensembl Human)
hsa-mir-16RnaENSG00000208006 (Ensembl Human)
hsa-mir-17RnaENSG00000207745 (Ensembl Human)
hsa-mir-181aRnaENSG00000207759 (Ensembl Human)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
hsa-mir-203GeneProductENSG00000207568 (Ensembl Human)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl Human)
hsa-mir-210GeneProductENSG00000199038 (Ensembl Human)
hsa-mir-21RnaENSG00000199004 (Ensembl Human)
hsa-mir-221RnaENSG00000207870 (Ensembl Human)
hsa-mir-222RnaENSG00000207725 (Ensembl Human)
hsa-mir-223GeneProductENSG00000207939 (Ensembl Human)
hsa-mir-24GeneProductENSG00000207617 (Ensembl Human)
hsa-mir-29aRnaENSG00000198981 (Ensembl Human)
hsa-mir-29bRnaENSG00000207748 (Ensembl Human)
hsa-mir-29cRnaENSG00000207966 (Ensembl Human)
hsa-mir-330GeneProductENSG00000199066 (Ensembl Human)
hsa-mir-34bRnaENSG00000207811 (Ensembl Human)
hsa-mir-34cRnaENSG00000207562 (Ensembl Human)
hsa-mir-373GeneProductENSG00000199143 (Ensembl Human)
hsa-mir-421RnaENSG00000202566 (Ensembl Human)
hsa-mir-424RnaENSG00000199097 (Ensembl Human)
hsa-mir-449aRnaENSG00000198983 (Ensembl Human)
hsa-mir-449bRnaENSG00000207728 (Ensembl Human)

Annotated Interactions

No annotated interactions

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