miRNA regulation of DNA damage response (Homo sapiens)
From WikiPathways
Description
This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.
If it is not mentioned different, the processes take place in the cell cytoplasm.
The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arrangedQuality Tags
Ontology Terms
Bibliography
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- Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M; ''The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
- Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Bâˆڑأ‰آ¬âˆڈrresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V; ''p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.''; Mol Syst Biol, 2008 PubMed Europe PMC Scholia
- Lâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
- Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC Scholia
- Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M; ''p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
- Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC Scholia
- Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW; ''The negative role of cyclin G in ATM-dependent p53 activation.''; Oncogene, 2004 PubMed Europe PMC Scholia
- Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC Scholia
- Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
- Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
- Toledo F, Wahl GM; ''Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
- Cuesta R, Martâˆڑأ‰آ¬â‰ nez-Sâˆڑأ‰آ¬آ°nchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
- Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
- Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
- Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC Scholia
- Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC Scholia
- Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
- Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P, Petrelli NJ, Dunn SP, Krueger LJ; ''MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.''; Cancer Res, 2007 PubMed Europe PMC Scholia
- Chargari C, Toillon RA, Macdermed D, Castadot P, Magnâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
- Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
- Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
- Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
- Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
- Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
- Bueno MJ, Pâˆڑأ‰آ¬آ©rez de Castro I, Gâˆڑأ‰آ¬â‰¥mez de Cedrâˆڑأ‰آ¬â‰¥n M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernâˆڑأ‰آ¬آ°ndez-Piqueras J, Malumbres M; ''Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.''; Cancer Cell, 2008 PubMed Europe PMC Scholia
- ''''; , PubMed Europe PMC Scholia
- Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC Scholia
- Woods K, Thomson JM, Hammond SM; ''Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
- Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
- Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
- Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
- O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT; ''c-Myc-regulated microRNAs modulate E2F1 expression.''; Nature, 2005 PubMed Europe PMC Scholia
- Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC Scholia
- Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC Scholia
- Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
- Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U; ''Dynamics of the p53-Mdm2 feedback loop in individual cells.''; Nat Genet, 2004 PubMed Europe PMC Scholia
- Coller HA, Forman JJ, Legesse-Miller A; ''"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron.''; PLoS Genet, 2007 PubMed Europe PMC Scholia
- Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC Scholia
- Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC Scholia
- Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafrâˆڑأ‰آ¬آ® SA, Farace MG; ''miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
- Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Mâˆڑأ‰آ¬آ؛ller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMed Europe PMC Scholia
- Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC Scholia
- Gong H, Cao Y, Han G, Zhang Y, You Q, Wang Y, Pan Y; '' Current Issue Forthcoming Issue Special Issues Most Read Most Cited (Dimensions) Most Cited (CrossRef) Social Media Archive Information Online Submission Information for Authors Language Editing Information for Reviewers Editorial Policies Editorial Academy Join Editorial Academy Aims and Scope Abstracting and Indexing Bibliographic Information Information for Librarians Information for Advertisers Reprints and permissions Contact the Editor General Information About Spandidos Conferences Job Opportunities Contact Terms and Conditions p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage''; https://doi.org/10.3892/ijo.2017.3922, 2017 PubMed Europe PMC Scholia
- Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC Scholia
- Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
- Pothof J, Verkaik NS, van IJcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP; ''MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.''; EMBO J, 2009 PubMed Europe PMC Scholia
- Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, Croce CM, Bolondi L, Negrini M; ''MicroRNA involvement in hepatocellular carcinoma.''; J Cell Mol Med, 2008 PubMed Europe PMC Scholia
- Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
- Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
GeneProduct | |||
7-hydroxystaurosporine | Metabolite | 65225 (Chemspider) | |
ABL1 | GeneProduct | ENSG00000097007 (Ensembl Human) | |
APAF1 | GeneProduct | ENSG00000120868 (Ensembl Human) | |
ATM | GeneProduct | ENSG00000149311 (Ensembl Human) | |
ATR | GeneProduct | ENSG00000175054 (Ensembl Human) | |
ATRIP | GeneProduct | 84126 (Entrez Gene) | |
BAX | GeneProduct | ENSG00000087088 (Ensembl Human) | |
BBC3 | GeneProduct | ENSG00000105327 (Ensembl Human) | |
BID | GeneProduct | ENSG00000015475 (Ensembl Human) | |
BRCA1 | GeneProduct | ENSG00000012048 (Ensembl Human) | |
CASP3 | GeneProduct | ENSG00000164305 (Ensembl Human) | |
CASP8 | GeneProduct | ENSG00000064012 (Ensembl Human) | |
CASP9 | GeneProduct | ENSG00000132906 (Ensembl Human) | |
CCNB1 | GeneProduct | ENSG00000134057 (Ensembl Human) | |
CCNB2 | GeneProduct | ENSG00000157456 (Ensembl Human) | |
CCNB3 | GeneProduct | ENSG00000147082 (Ensembl Human) | |
CCND1 | GeneProduct | ENSG00000110092 (Ensembl Human) | |
CCND2 | GeneProduct | ENSG00000118971 (Ensembl Human) | |
CCND3 | GeneProduct | ENSG00000112576 (Ensembl Human) | |
CCNE1 | GeneProduct | ENSG00000105173 (Ensembl Human) | |
CCNE2 | GeneProduct | ENSG00000175305 (Ensembl Human) | |
CDC20B | GeneProduct | 166979 (Entrez Gene) | |
CDC25A | GeneProduct | ENSG00000164045 (Ensembl Human) | |
CDC25C | GeneProduct | ENSG00000158402 (Ensembl Human) | |
CDK1 | GeneProduct | ENSG00000170312 (Ensembl Human) | |
CDK2 | GeneProduct | ENSG00000123374 (Ensembl Human) | |
CDK4 | GeneProduct | ENSG00000135446 (Ensembl Human) | |
CDK5 | GeneProduct | ENSG00000164885 (Ensembl Human) | |
CDK6 | GeneProduct | ENSG00000105810 (Ensembl Human) | |
CDKN1A | GeneProduct | ENSG00000124762 (Ensembl Human) | |
CDKN1B | GeneProduct | ENSG00000111276 (Ensembl Human) | |
CHEK1 | GeneProduct | ENSG00000149554 (Ensembl Human) | |
CHEK2 | GeneProduct | ENSG00000183765 (Ensembl Human) | |
CREB1 | GeneProduct | 1385 (Entrez Gene) | |
CYCS | GeneProduct | ENSG00000172115 (Ensembl Human) | |
Caffeine | Metabolite | 2424 (Chemspider) | |
DDB2 | GeneProduct | ENSG00000134574 (Ensembl Human) | |
E2F1 | GeneProduct | ENSG00000101412 (Ensembl Human) | |
Estradiol | Metabolite | 16469 (ChEBI) | |
FANCD2 | GeneProduct | ENSG00000144554 (Ensembl Human) | |
FAS | GeneProduct | ENSG00000026103 (Ensembl Human) | |
GADD45A | GeneProduct | ENSG00000116717 (Ensembl Human) | |
GADD45B | GeneProduct | ENSG00000099860 (Ensembl Human) | |
GADD45G | GeneProduct | ENSG00000130222 (Ensembl Human) | |
GeneProduct | GeneProduct | ||
H2AFX | GeneProduct | ENSG00000188486 (Ensembl Human) | |
HUS1 | GeneProduct | ENSG00000188996 (Ensembl Human) | |
MCM7 | GeneProduct | 4176 (Entrez Gene) | |
MIRHG1 | GeneProduct | ENSG00000215417 (Ensembl Human) | |
MRE11 | GeneProduct | 4361 (Entrez Gene) | |
NBN | GeneProduct | 4683 (Entrez Gene) | |
PIDD | GeneProduct | 55367 (Entrez Gene) | |
PMAIP1 | GeneProduct | ENSG00000141682 (Ensembl Human) | |
PML | GeneProduct | ENSG00000140464 (Ensembl Human) | |
PRKDC | GeneProduct | ENSG00000121031 (Ensembl Human) | |
RAD17 | GeneProduct | ENSG00000152942 (Ensembl Human) | |
RAD1 | GeneProduct | ENSG00000113456 (Ensembl Human) | |
RAD50 | GeneProduct | ENSG00000113522 (Ensembl Human) | |
RAD51 | GeneProduct | ENSG00000051180 (Ensembl Human) | |
RAD52 | GeneProduct | ENSG00000002016 (Ensembl Human) | |
RAD9A | GeneProduct | ENSG00000172613 (Ensembl Human) | |
RB1 | GeneProduct | ENSG00000139687 (Ensembl Human) | |
RFC | GeneProduct | 5981 (Entrez Gene) | |
RPA2 | GeneProduct | ENSG00000117748 (Ensembl Human) | |
RRM2B | GeneProduct | ENSG00000048392 (Ensembl Human) | |
SESN1 | GeneProduct | ENSG00000080546 (Ensembl Human) | |
SFN | GeneProduct | ENSG00000175793 (Ensembl Human) | |
SMC1A | GeneProduct | ENSG00000072501 (Ensembl Human) | |
TLK1 | GeneProduct | ENSG00000198586 (Ensembl Human) | |
TLK2 | GeneProduct | ENSG00000146872 (Ensembl Human) | |
TNFRSF10B | GeneProduct | ENSG00000120889 (Ensembl Human) | |
TP53AIP1 | GeneProduct | ENSG00000120471 (Ensembl Human) | |
TP53 | GeneProduct | ENSG00000141510 (Ensembl Human) | |
c-Myc | GeneProduct | 4609 (Entrez Gene) | |
hsa-let-7a-1 | Rna | ENSG00000199165 (Ensembl Human) | |
hsa-mir-106b | Rna | ENSG00000208036 (Ensembl Human) | |
hsa-mir-145 | Rna | ENSG00000207700 (Ensembl Human) | |
hsa-mir-15a | Rna | ENSG00000207718 (Ensembl Human) | |
hsa-mir-16 | Rna | ENSG00000208006 (Ensembl Human) | |
hsa-mir-17 | Rna | ENSG00000207745 (Ensembl Human) | |
hsa-mir-181a | Rna | ENSG00000207759 (Ensembl Human) | |
hsa-mir-195 | Rna | ENSG00000207929 (Ensembl Human) | |
hsa-mir-203 | GeneProduct | ENSG00000207568 (Ensembl Human) | |
hsa-mir-20a | GeneProduct | ENSG00000199149 (Ensembl Human) | |
hsa-mir-210 | GeneProduct | ENSG00000199038 (Ensembl Human) | |
hsa-mir-21 | Rna | ENSG00000199004 (Ensembl Human) | |
hsa-mir-221 | Rna | ENSG00000207870 (Ensembl Human) | |
hsa-mir-222 | Rna | ENSG00000207725 (Ensembl Human) | |
hsa-mir-223 | GeneProduct | ENSG00000207939 (Ensembl Human) | |
hsa-mir-24 | GeneProduct | ENSG00000207617 (Ensembl Human) | |
hsa-mir-29a | Rna | ENSG00000198981 (Ensembl Human) | |
hsa-mir-29b | Rna | ENSG00000207748 (Ensembl Human) | |
hsa-mir-29c | Rna | ENSG00000207966 (Ensembl Human) | |
hsa-mir-330 | GeneProduct | ENSG00000199066 (Ensembl Human) | |
hsa-mir-34b | Rna | ENSG00000207811 (Ensembl Human) | |
hsa-mir-34c | Rna | ENSG00000207562 (Ensembl Human) | |
hsa-mir-373 | GeneProduct | ENSG00000199143 (Ensembl Human) | |
hsa-mir-421 | Rna | ENSG00000202566 (Ensembl Human) | |
hsa-mir-424 | Rna | ENSG00000199097 (Ensembl Human) | |
hsa-mir-449a | Rna | ENSG00000198983 (Ensembl Human) | |
hsa-mir-449b | Rna | ENSG00000207728 (Ensembl Human) |
Annotated Interactions
No annotated interactions