Angiogenesis (Homo sapiens)

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HRE Target GenesTarget GenesHypoxia Vascular budding throughEPC recruitionCelmemembraneDNAEPC mobilizationBasement membranedegradationCelmembraneCytoplasmUpregulation proteasesCel replicationCapillary tubule formationProliferation and differentiationof ECs, SMCs and fibroblastsVessel StabilizationExtracellularStabilization of newly formedvesselsCell growth and divisionAttraction of pericytes and SMCsNucleusPDGFBTIMP3MMP9HIF1ACBPVEGFR2FGF2FGFR2Ang 1VEGFATIMP2sTIE2PDGFRAMMP2FGF2PDGFBVEGFAHIF1ATIE2FLT1HIF1BAng 1


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Bibliography

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  1. Hellberg C, Ostman A, Heldin CH; ''PDGF and vessel maturation.''; Recent Results Cancer Res, 2010 PubMed Europe PMC Scholia
  2. Renault MA, Losordo DW; ''The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.''; Circ Res, 2007 PubMed Europe PMC Scholia
  3. Tomanek RJ, Zheng W, Yue X; ''Growth factor activation in myocardial vascularization: therapeutic implications.''; Mol Cell Biochem, 2004 PubMed Europe PMC Scholia
  4. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR; ''Angiopoietin-1 in the treatment of ischemia and sepsis.''; Shock, 2009 PubMed Europe PMC Scholia
  5. Millauer B, Wizigmann-Voos S, Schnuerch H, Martinez R, Moller NP, Risau W, Ullrich A; ''High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.''; Cell, 1993 PubMed Europe PMC Scholia
  6. Kutryk MJ, Stewart DJ; ''Angiogenesis of the heart.''; Microsc Res Tech, 2003 PubMed Europe PMC Scholia
  7. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L; ''Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model.''; Microvasc Res, 2010 PubMed Europe PMC Scholia
  8. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W; ''Angiopoietin-1 induces sprouting angiogenesis in vitro.''; Curr Biol, 1998 PubMed Europe PMC Scholia
  9. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D; ''Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  10. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS; ''Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.''; Circ Res, 2001 PubMed Europe PMC Scholia
  11. ; ''Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html, 2008
  12. Burbridge MF, Coge F, Galizzi JP, Boutin JA, West DC, Tucker GC; ''The role of the matrix metalloproteinases during in vitro vessel formation.''; Angiogenesis, 2002 PubMed Europe PMC Scholia
  13. Madeddu P; ''Therapeutic angiogenesis and vasculogenesis for tissue regeneration.''; Exp Physiol, 2005 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139047view00:14, 13 May 2025Khanspersincrease font size
137108view22:58, 27 February 2025KhanspersModified description
128558view05:00, 12 February 2024EweitzStandardize case
118358view13:36, 27 May 2021Mkutmonfixed publication references
118356view13:35, 27 May 2021Mkutmonremoved redundant reference
105882view04:53, 16 August 2019KhanspersModified description
105475view05:21, 8 August 2019KhanspersModified description
95042view01:52, 6 November 2017AlexanderPicoannotated cellular compartments
88983view09:51, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79949view10:53, 28 April 2015ZariChanged Drosophila ID to human ID for p38 MAPK
78807view09:16, 31 January 2015EgonwAccidental commit; reverting, just in case.
78806view09:15, 31 January 2015EgonwWP254
78805view09:14, 31 January 2015EgonwConnected a dot (by adding an invisible box).
75222view22:04, 9 May 2014Khanspersfixed connections and groups
74474view04:33, 25 April 2014EgonwFixed a PubMed ID.
71713view20:05, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
63161view20:19, 8 May 2013MaintBotUpdating GPML version
59198view19:08, 22 February 2013MaintBotUpdated Ensembl data source
58504view18:59, 14 February 2013MaintBotModified description
44952view12:37, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
42601view20:32, 10 April 2011AlexanderPicoupdated HIF1B to ARNT
42554view14:01, 4 April 2011ToxlabProvided entrez Gene ID for FGFR2
42553view13:43, 4 April 2011ToxlabAdded data base ref to FGF2
41185view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
38974view18:27, 25 September 2010AlexanderPicofixed groups, labels and lines
38945view23:09, 24 September 2010KhanspersFixed data nodes
38944view23:03, 24 September 2010KhanspersChanged cell compartments
37853view18:22, 12 July 2010KhanspersModified categories
37640view15:30, 14 June 2010LauraSSpecify description
37639view15:22, 14 June 2010LauraSModified description
37638view15:21, 14 June 2010LauraSModified description
37637view15:05, 14 June 2010LauraSSpecify description
37636view14:55, 14 June 2010LauraSPeriodical save, work in progress
37635view14:45, 14 June 2010LauraSPeriodical save, work in progress
37631view14:31, 14 June 2010LauraSSpecify description
37630view14:30, 14 June 2010LauraSSpecify description
37627view14:11, 14 June 2010LauraSSpecify description
37626view14:08, 14 June 2010LauraS14-06-2010
37624view14:00, 14 June 2010LauraS14-06-2010
37622view13:55, 14 June 2010LauraSPeriodical save, work in progress
37621view13:44, 14 June 2010LauraSPeriodical save, work in progress
37620view13:34, 14 June 2010LauraSPeriodical save, work in progress
37619view13:24, 14 June 2010LauraSPeriodical save, work in progress
37618view13:14, 14 June 2010LauraSPeriodical save, work in progress
37617view13:03, 14 June 2010LauraSPeriodical save, work in progress
37616view12:53, 14 June 2010LauraSPeriodical save, work in progress
37615view12:43, 14 June 2010LauraSPeriodical save, work in progress
37614view12:33, 14 June 2010LauraSPeriodical save, work in progress
37222view16:00, 22 May 2010LauraSSpecify description
37221view15:29, 22 May 2010LauraSPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
Ang 1GeneProductQ15389 (Uniprot/TrEMBL)
CBPGeneProduct1387 (Entrez Gene)
FGF2GeneProductENSG00000138685 (Ensembl Human)
FGFR2GeneProductENSG00000066468 (Uniprot/TrEMBL)
FLT1GeneProductENSG00000102755 (Ensembl Human)
HIF1AGeneProductQ16665 (Uniprot/TrEMBL)
HIF1BGeneProduct405 (Entrez Gene)
MMP2GeneProductENSG00000100985 (Ensembl Human)
MMP9GeneProductENSG00000100985 (Ensembl Human)
PDGFBGeneProductENSG00000100311 (Ensembl Human)
PDGFRAGeneProductP16234 (Uniprot/TrEMBL)
TIE2GeneProduct7010 (Entrez Gene)
TIMP2GeneProductENSG00000035862 (Ensembl Human)
TIMP3ProteinENSG00000100234 (Ensembl Human)
VEGFAGeneProductP15692 (Uniprot/TrEMBL)
VEGFR2GeneProduct3791 (Entrez Gene)
sTIE2GeneProduct7010 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1539"
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