Target of rapamycin (TOR) signaling (Sus scrofa)

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1, 3-52Amino acidsHypoxiaInsulin signalingInsulin signalingmRNA translationSurvivalhigh AMP:ATPAmino acid transportermTORC2mTORC1AMPKCytoskeletal dynamicsribosome biogenesisautophagyActin organisationEIF4EBP1PRKAA1TSC2PRKAA2ULK1DDIT4PRKAG1MAPKAP1PRR5AKT1RRAGBCDC42PRKAB2MTORRICTORRPS6KB1FKBP1AAKT1S1PRKCARHEBULK3MLST8RapamycinRRAGCPRKAB1PRR5LPRKAG2PRKAG3RPTORRAC1ULK2RRAGATSC1MTORRRAGDDDIT4LMLST8


Description

TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1471(r36157) with a 61% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC Scholia
  2. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC Scholia
  3. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
  4. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC Scholia
  5. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128735view03:06, 21 February 2024EweitzUpgrade disease node, standardize case
116799view10:02, 14 May 2021EweitzModified title
87801view11:21, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87800view11:21, 25 July 2016MirellaKalafatiModified title
68432view18:56, 5 July 2013MaintBotUpdated to 2013 gpml schema
59001view20:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41929view05:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
37713view20:24, 28 June 2010MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct
AKT1S1GeneProductENSSSCG00000003194 (Ensembl Pig)
CDC42GeneProduct
DDIT4GeneProductENSSSCG00000010287 (Ensembl Pig)
DDIT4LGeneProductENSSSCG00000009174 (Ensembl Pig)
EIF4EBP1GeneProduct
FKBP1AGeneProduct
MAPKAP1GeneProduct
MLST8GeneProduct
MTORGeneProductENSSSCG00000003413 (Ensembl Pig)
PRKAA1GeneProductENSSSCG00000016858 (Ensembl Pig)
PRKAA2GeneProductENSSSCG00000003837 (Ensembl Pig)
PRKAB1GeneProductENSSSCG00000009840 (Ensembl Pig)
PRKAB2GeneProductENSSSCG00000006703 (Ensembl Pig)
PRKAG1GeneProductENSSSCG00000000185 (Ensembl Pig)
PRKAG2GeneProductENSSSCG00000016432 (Ensembl Pig)
PRKAG3GeneProductENSSSCG00000016200 (Ensembl Pig)
PRKCAGeneProduct
PRR5GeneProduct
PRR5LGeneProductENSSSCG00000013292 (Ensembl Pig)
RAC1GeneProduct
RHEBGeneProductENSSSCG00000016434 (Ensembl Pig)
RICTORGeneProductENSSSCG00000016853 (Ensembl Pig)
RPS6KB1GeneProductENSSSCG00000017670 (Ensembl Pig)
RPTORGeneProduct
RRAGAGeneProductENSSSCG00000005174 (Ensembl Pig)
RRAGBGeneProductENSSSCG00000012351 (Ensembl Pig)
RRAGCGeneProductENSSSCG00000003648 (Ensembl Pig)
RRAGDGeneProduct
RapamycinMetabolite7847818 (PubChem)
TSC1GeneProduct
TSC2GeneProductENSSSCG00000008040 (Ensembl Pig)
ULK1GeneProductENSSSCG00000009742 (Ensembl Pig)
ULK2GeneProduct
ULK3GeneProductENSSSCG00000001898 (Ensembl Pig)

Annotated Interactions

No annotated interactions
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