Heart development (Homo sapiens)
From WikiPathways
Description
This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by an arrow while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.
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Ontology Terms
Bibliography
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- Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O; ''BMP and BMP receptor expression during murine organogenesis.''; Gene Expr Patterns, 2009 PubMed Europe PMC Scholia
- Fulcoli FG, Huynh T, Scambler PJ, Baldini A; ''Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.''; PLoS One, 2009 PubMed Europe PMC Scholia
- Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP; ''An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.''; Cell, 2007 PubMed Europe PMC Scholia
- Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D; ''Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.''; Cell, 2010 PubMed Europe PMC Scholia
- Srivastava D; ''Making or breaking the heart: from lineage determination to morphogenesis.''; Cell, 2006 PubMed Europe PMC Scholia
- Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D; ''A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
- Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT; ''Development of heart valves requires Gata4 expression in endothelial-derived cells.''; Development, 2006 PubMed Europe PMC Scholia
- Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D; ''miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.''; Nature, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
BHLHE40 | GeneProduct | 8553 (Entrez Gene) | In other species, this is BHLHB2 |
BMP10 | GeneProduct | 27302 (Entrez Gene) | |
BMP2 | GeneProduct | 650 (Entrez Gene) | |
BMP4 | GeneProduct | 652 (Entrez Gene) | |
BMPR1A | GeneProduct | 657 (Entrez Gene) | |
BMPR2 | GeneProduct | 659 (Entrez Gene) | |
CTNNB1 | GeneProduct | 1499 (Entrez Gene) | |
ERBB3 | GeneProduct | 2065 (Entrez Gene) | |
FGF10 | GeneProduct | 2255 (Entrez Gene) | |
FGF8 | GeneProduct | 2253 (Entrez Gene) | |
FOXA2 | GeneProduct | 3170 (Entrez Gene) | |
FOXC1 | GeneProduct | 2296 (Entrez Gene) | |
FOXC2 | GeneProduct | 2303 (Entrez Gene) | |
FOXH1 | GeneProduct | 8928 (Entrez Gene) | |
GATA4 | GeneProduct | 2626 (Entrez Gene) | |
GATA6 | GeneProduct | 2627 (Entrez Gene) | |
HAND1 | GeneProduct | 9421 (Entrez Gene) | |
HAND2 | GeneProduct | 9464 (Entrez Gene) | |
HEY1 | GeneProduct | 23462 (Entrez Gene) | |
HEY2 | GeneProduct | 23493 (Entrez Gene) | |
IRX4 | GeneProduct | 50805 (Entrez Gene) | |
ISL1 | GeneProduct | 3670 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MEF2C | GeneProduct | 4208 (Entrez Gene) | |
MIR1-1 | GeneProduct | ENSG00000199017 (Ensembl Human) | |
MIR143 | GeneProduct | ENSG00000208035 (Ensembl Human) | |
MIR145 | GeneProduct | ENSG00000207700 (Ensembl Human) | |
NFATC1 | GeneProduct | 4772 (Entrez Gene) | |
NFATC2 | GeneProduct | 4773 (Entrez Gene) | |
NFATC3 | GeneProduct | 4775 (Entrez Gene) | |
NFATC4 | GeneProduct | 4776 (Entrez Gene) | |
NKX2-5 | GeneProduct | 1482 (Entrez Gene) | |
NOTCH1 | GeneProduct | 4851 (Entrez Gene) | |
PITX2 | GeneProduct | 5308 (Entrez Gene) | |
PTPN11 | GeneProduct | 5781 (Entrez Gene) | |
SHH | GeneProduct | 6469 (Entrez Gene) | |
SMAD1 | GeneProduct | 4086 (Entrez Gene) | |
SMAD4 | GeneProduct | 4089 (Entrez Gene) | |
SMYD1 | GeneProduct | 150572 (Entrez Gene) | |
SRF | GeneProduct | 6722 (Entrez Gene) | |
TBX1 | GeneProduct | 6899 (Entrez Gene) | |
TBX20 | GeneProduct | 57057 (Entrez Gene) | |
TBX2 | GeneProduct | 6909 (Entrez Gene) | |
TBX5 | GeneProduct | 6910 (Entrez Gene) | |
VEGFA | GeneProduct | 7422 (Entrez Gene) | |
VEGFB | GeneProduct | 7423 (Entrez Gene) | |
VEGFC | GeneProduct | 7424 (Entrez Gene) |
Annotated Interactions
No annotated interactions