Mechanisms associated with pluripotency (Mus musculus)

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Description

The aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we intentionally focused on information flow, neglecting reactions, metabolites, intracellular movement of components, and their modifications such as protein phosphorylation Each edge can be seen as direct mechanism between its nodes.

For more information, see

Som A, Harder C, Greber B, Siatkowski M, Paudel Y, et al. 2010 The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165

The June 2010 PluriNetWork described in the paper can be found at http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/ . The PluriNetWork at WikiPathWays started with the December 2010 version.


We are aware that 'This pathway contains unconnected lines', but to resolve this problem, we need to work around the wikipathways limitation that a node may have at most 12 incoming edge points.

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Bibliography

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  1. Foshay K, Gallicano G; ''Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate''; Stem Cells and Development, 2008 PubMed Europe PMC Scholia
  2. Do JT, Schöler HR; ''Regulatory circuits underlying pluripotency and reprogramming''; Trends Pharmacol Sci, 2009 PubMed Europe PMC Scholia
  3. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, Farina A, Martinez E; ''Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  4. Gao F, Kwon SW, Zhao Y, Jin Y; ''PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  5. Schugar RC, Robbins PD, Deasy BM; ''Small molecules in stem cell self-renewal and differentiation''; Gene Ther, 2008 PubMed Europe PMC Scholia
  6. Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, Yagi K, Miyazaki J, Matoba R, Ko MS, Niwa H; ''Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  7. Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ; ''Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  8. Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P; ''Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog''; Stem Cells, 2009 PubMed Europe PMC Scholia
  9. Zhong X, Jin Y; ''Critical Roles of Coactivator p300 in Mouse Embryonic Stem Cell Differentiation and Nanog Expression''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  10. Sun Y, Li H, Liu Y, Mattson MP, Rao MS, Zhan M; ''Evolutionarily Conserved Transcriptional Co-Expression Guiding Embryonic Stem Cell Differentiation''; Crit Rev Eukaryot Gene Expr, 2006 PubMed Europe PMC Scholia
  11. Wang ZX, Kueh JL, Teh CH, Rossbach M, Lim L, Li P, Wong KY, Lufkin T, Robson P, Stanton LW; ''Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells''; Stem Cells, 2007 PubMed Europe PMC Scholia
  12. Barnea E, Bergman Y; ''Synergy of SF1 and RAR in activation of Oct-3/4 promoter''; J Mol Chem, 2000 PubMed Europe PMC Scholia
  13. Rowland BD, Bernards R, Peeper DS; ''The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene''; Nat Cell Biol, 2005 PubMed Europe PMC Scholia
  14. Hemberger M, Dean W, Reik W; ''Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal''; Nat Rev Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  15. Rao; ''Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells''; Dev Biol, 2004 PubMed Europe PMC Scholia
  16. Kurooka H, Honjo T; ''Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  17. Majewski M, Nieborowska-Skorska M, Salomoni P, Slupianek A, Reiss K, Trotta R, Calabretta B, Skorski T; ''Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt1''; Cancer Res, 1999 PubMed Europe PMC Scholia
  18. Benetti R, Gonzalo S, Jaco I, Muñoz P, Gonzalez S, Schoeftner S, Murchison E, Andl T, Chen T, Klatt P, Li E, Serrano M, Millar S, Hannon G, Blasco MA; ''A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases''; Nature Structural & Molecular Biology, 2008 PubMed Europe PMC Scholia
  19. Mazumdar J, Dondeti V, Simon MC; ''Hypoxia-inducible factors in stem cells and cancer''; J Cell Mol Med, 2009 PubMed Europe PMC Scholia
  20. Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH; ''A protein interaction network for pluripotency of embryonic stem cells''; Nature, 2006 PubMed Europe PMC Scholia
  21. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr; ''Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen''; Science, 1994 PubMed Europe PMC Scholia
  22. Endoh M, Endo TA, Endoh T, Fujimura Y, Ohara O, Toyoda T, Otte AP, Okano M, Brockdorff N, Vidal M, Koseki H; ''Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity''; Development, 2008 PubMed Europe PMC Scholia
  23. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z, Thomson JA, Zwaka TP; ''Ronin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells''; Cell, 2008 PubMed Europe PMC Scholia
  24. Kuroda T, Tada M, Kubota H, Kimura H, Hatano S, Suemori H, Nakatsuji N, Tada T; ''Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression''; Molecular and Cellular Biology, 2005 PubMed Europe PMC Scholia
  25. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH; ''Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  26. Lu J, Jeong HW, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Yupoma, Chai L; ''Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex''; PLoS One, 2009 PubMed Europe PMC Scholia
  27. Yu HB, Kunarso G, Hong FH, Stanton LW; ''Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  28. Liu Y, Ji L, Ten Y, Wang Y, Pei X; ''The molecular mechanism of embryonic stem cell pluripotency and self-renewal''; Sci China C Life Sci, 2007 PubMed Europe PMC Scholia
  29. Harms KL, Chen X; ''The C Terminus of p53 Family Proteins Is a Cell Fate Determinant''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  30. Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J; ''An expanded Oct4 interaction network: implications for stem cell biology, development, and disease''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia
  31. Mullen EM, Gu P, Cooney AJ; ''Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation''; PPAR Res, 2007 PubMed Europe PMC Scholia
  32. Schoorlemmer J, van Puijenbroek A, van Den Eijnden M, Jonk L, Pals C, Kruijer W; ''Characterization of a negative retinoic acid response element in the murine Oct4 promoter''; Molecular and Cellular Biology, 1994 PubMed Europe PMC Scholia
  33. Feng B, Jiang J, Kraus P, Ng JH, Heng JC, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T, Ng HH; ''Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb''; Nature Cell Biology, 2009 PubMed Europe PMC Scholia
  34. Xie X, Chan RJ, Yoder MC; ''Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation''; FEBS Lett, 2002 PubMed Europe PMC Scholia
  35. Tutter AV, Kowalski MP, Baltus GA, Iourgenko V, Labow M, Li E, Kadam S; ''Role for Med12 in regulation of Nanog and Nanog target genes''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  36. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z; ''Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells''; Nat Cell Biol, 2008 PubMed Europe PMC Scholia
  37. Sato N, Kondo M, Arai K; ''The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
  38. Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R; ''The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development''; Development, 2006 PubMed Europe PMC Scholia
  39. Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F, Niehrs C; ''Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation''; Nature, 2007 PubMed Europe PMC Scholia
  40. Liu X, Huang J, Chen T, Wang Y, Xin S, Li J, Pei G, Kang J; ''Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells''; Cell Research, 2008 PubMed Europe PMC Scholia
  41. Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J; ''Post-translational regulation of Oct4 transcriptional activity''; PLoS One, 2009 PubMed Europe PMC Scholia
  42. Gao Y, Wang B, Xiao Z, Chen B, Han J, Wang X, Zhang J, Gao S, Zhao Y, Dai J; ''Nogo-66 regulates Nanog expression through Stat3 pathway in murine embryonic stem cells''; Stem Cells Dev, 2010 PubMed Europe PMC Scholia
  43. Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD; ''Dax1 Up-Regulates Oct4 Expression in Mouse Embryonic Stem Cells via LRH-1 and SRA''; Mol Endocrinol, 2010 PubMed Europe PMC Scholia
  44. Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y; ''Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification''; Nature, 2010 PubMed Europe PMC Scholia
  45. Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Kim JH, Yoon DK, Kim KW; ''Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  46. Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, Niwa H, Yamanaka S; ''Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development''; Molecular and Cellular Biology, 2003 PubMed Europe PMC Scholia
  47. Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, Sheng HZ, Zhao YX, Zhao YM, Jin Y; ''Wwp2, an E3 Ubiquitin Ligase That Targets Transcription Factor Oct-4 for Ubiquitination''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  48. Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R; ''Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis''; PLoS One, 2009 PubMed Europe PMC Scholia
  49. Pan G, Thomson JA; ''Nanog and transcriptional networks in embryonic stem cell pluripotency''; Cell Research, 2007 PubMed Europe PMC Scholia
  50. Wong LH, McGhie JD, Sim M, Anderson MA, Ahn S, Hannan RD, George AJ, Morgan KA, Mann JR, Choo KH; ''ATRX interacts with H3 3 in maintaining telomere structural integrity in pluripotent embryonic stem cells''; Genome Res, 2010 PubMed Europe PMC Scholia
  51. Jeltsch A; ''Molecular enzymology of mammalian DNA methyltransferases''; Curr Top Microbiol Immunol, 2006 PubMed Europe PMC Scholia
  52. Wang ZX, Teh CH, Kueh JL, Lufkin T, Robson P, Stanton LW; ''Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  53. Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE; ''UHRF1 plays a role in maintaining DNA methylation in mammalian cells''; Science, 2007 PubMed Europe PMC Scholia
  54. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y; ''p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression''; Nat Cell Biol, 2005 PubMed Europe PMC Scholia
  55. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R, Sharov AA, Ko MS, Niwa H; ''Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells''; Nat Cell Biol, 2007 PubMed Europe PMC Scholia
  56. Zhou Q, Chipperfield H, Melton DA, Wong WH; ''A gene regulatory network in mouse embryonic stem cells''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  57. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT; ''Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch''; Mol Cell, 2007 PubMed Europe PMC Scholia
  58. Lensch MW, Daheron L, Schlaeger TM; ''Pluripotent Stem Cells and Their Niches''; Stem Cell Rev, 2006 PubMed Europe PMC Scholia
  59. Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G, Li J, Yamanaka S, Crider DG, Testa G, Li RA, Lim B, Stewart CL, Liu Y, Van Eyk JE, Wersto RP, Wobus AM, Boheler KR; ''B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells''; PLoS One, 2008 PubMed Europe PMC Scholia
  60. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH; ''A core Klf circuitry regulates self-renewal of embryonic stem cells''; Nat Cell Biol, 2008 PubMed Europe PMC Scholia
  61. Chakrabarty K, Heumann R; ''Prospective of Ras signaling in stem cells''; Biol Chem, 2008 PubMed Europe PMC Scholia
  62. Kidder BL, Yang J, Palmer S; ''Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells''; PLoS One, 2008 PubMed Europe PMC Scholia
  63. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Won Kwon S, Zhao Y, Li J, Jin Y; ''Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  64. Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, Senapati S, Batra SK; ''RNA Polymerase II-Association Factor 1 (Paf1/PD2) Maintains Self-renewal by Its Interaction with Oct3/4 in Mouse Embryonic Stem Cells''; Stem Cells, 2009 PubMed Europe PMC Scholia
  65. Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, Schöler HR; ''New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2''; Genes Dev, 1998 PubMed Europe PMC Scholia
  66. Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F, Leonhardt H; ''Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells''; EMBO Rep, 2009 PubMed Europe PMC Scholia
  67. Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW; ''Zic3 Is Required for Maintenance of Pluripotency in Embryonic Stem Cells''; Mol Biol Cell, 2007 PubMed Europe PMC Scholia
  68. Chambers I, Tomlinson SR; ''The transcriptional foundation of pluripotency''; Development, 2009 PubMed Europe PMC Scholia
  69. Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE; ''Telomerase modulates Wnt signalling by association with target gene chromatin''; Nature, 2009 PubMed Europe PMC Scholia
  70. Abdelalim EM, Tooyama I; ''BNP signaling is crucial for embryonic stem cell proliferation''; PLoS One, 2009 PubMed Europe PMC Scholia
  71. Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT; ''The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting''; Nature, 2009 PubMed Europe PMC Scholia
  72. Wang ZX, Teh CH, Chan CM, Chu C, Rossbach M, Kunarso G, Allapitchay TB, Wong KY, Stanton LW; ''The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes''; Stem Cells, 2008 PubMed Europe PMC Scholia
  73. Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, Blasco MA, Serrano M; ''The Ink4/Arf locus is a barrier for iPS cell reprogramming''; Nature, 2009 PubMed Europe PMC Scholia
  74. Schoorlemmer J, Kruijer W; ''Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells''; Mech Dev, 1991 PubMed Europe PMC Scholia
  75. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, Clark AT, Wong DT; ''Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  76. Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, Bak M, Tommerup N, Rappsilber J, Helin K; ''JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells''; Nature, 2010 PubMed Europe PMC Scholia
  77. Hashimoto Y, Myojin R, Katoh N, Ohtsu M, Tashiro F, Onoda F, Murakami Y; ''The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation''; Biochem Biophys Res Commun, 2009 PubMed Europe PMC Scholia
  78. Takahashi K, Murakami M, Yamanaka S; ''Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  79. Zhang P, Andrianakos R, Yang Y, Liu C, Lu W; ''Kruppel-like factor 4 (KLF4) prevents embryonic stem (ES) cell differentiation by regulating nanog gene expression''; J Mol Chem, 2010 PubMed Europe PMC Scholia
  80. van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E; ''Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes''; Mol Cell Biol, 1998 PubMed Europe PMC Scholia
  81. Wang J, Levasseur DN, Orkin SH; ''Requirement of Nanog dimerization for stem cell self-renewal and pluripotency''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  82. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  83. Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, Matsuda T, Koide H, Yokota T; ''STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  84. Tapscott SJ; ''The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription''; Development, 2005 PubMed Europe PMC Scholia
  85. Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H; ''Degradation of chromosomal DNA during apoptosis''; Cell Death Differ, 2003 PubMed Europe PMC Scholia
  86. Choi Y, Rajkovic A; ''Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  87. Solozobova V, Blattner C; ''Regulation of p53 in embryonic stem cells''; Exp Cell Res, 2010 PubMed Europe PMC Scholia
  88. Qi X, Li TG, Hao J, Hu J, Wang J, Simmons H, Miura S, Mishina Y, Zhao GQ; ''BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  89. Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P; ''Molecular coupling of Xist regulation and pluripotency''; Science, 2008 PubMed Europe PMC Scholia
  90. Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG; ''A small molecule primes embryonic stem cells for differentiation''; Cell Stem Cell, 2009 PubMed Europe PMC Scholia
  91. Yuan H, Corbi N, Basilico C, Dailey L; ''Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3/4/4''; Genes Dev, 1995 PubMed Europe PMC Scholia
  92. Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, Lou Y, Yang J, Ma Y, Chai L, Ng HH, Lufkin T, Robson P, Lim B; ''Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  93. Xi S, Geiman TM, Briones V, Guang Tao Y, Xu H, Muegge K; ''Lsh participates in DNA methylation and silencing of stem cell genes''; Stem Cells, 2009 PubMed Europe PMC Scholia
  94. Lee J, Kim HK, Han YM, Kim J; ''Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
  95. Epsztejn-Litman S, Feldman N, Abu-Remaileh M, Shufaro Y, Gerson A, Ueda J, Deplus R, Fuks F, Shinkai Y, Cedar H, Bergman Y; ''De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes''; Nat Struct Mol Biol, 2008 PubMed Europe PMC Scholia
  96. Boiani M, Schöler HR; ''Regulatory networks in embryo-derived pluripotent stem cells''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  97. Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P; ''Transcriptional regulation of nanog by OCT4 and SOX2''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  98. Hamazaki T, Kehoe SM, Nakano T, Terada N; ''The Grb2/Mek pathway represses Nanog in murine embryonic stem cells''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  99. Hall J, Guo G, Wray J, Eyres I, Nichols J, Grotewold L, Morfopoulou S, Humphreys P, Mansfield W, Walker R, Tomlinson S, Smith A; ''Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal''; Cell Stem Cell, 2009 PubMed Europe PMC Scholia
  100. Moretto-Zita M, Jin H, Shen Z, Zhao T, Briggs SP, Xu Y; ''Phosphorylation stabilizes Nanog by promoting its interaction with Pin1''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  101. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K; ''UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development''; Nature, 2007 PubMed Europe PMC Scholia
  102. Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W; ''Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming''; Stem Cells, 2009 PubMed Europe PMC Scholia
  103. Silva J, and Smith A; ''Capturing Pluripotency''; Cell, 2008 PubMed Europe PMC Scholia
  104. Matoba R, Niwa H, Masui S, Ohtsuka S, Carter MG, Sharov AA, Ko MS; '' Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling''; PLoS One, 2006 PubMed Europe PMC Scholia
  105. Niwa H, Ogawa K, Shimosato D, Adachi K; ''A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells''; Nature, 2009 PubMed Europe PMC Scholia
  106. Ramos JW; ''The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
  107. Jaenisch R, Young R; ''Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming''; Cell, 2008 PubMed Europe PMC Scholia
  108. Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, Biggs JR, Kraft AS, Yang VW; ''The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  109. Reinhold MI, Kapadia RM, Liao Z, Naski MC; ''The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  110. Larsen BD, Rampalli S, Burns LE, Brunette S, Dilworth FJ, Megeney LA; ''Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  111. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, Morishita Y, Watabe T, Niwa H, Miyazono K; ''Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells''; Journal of Cell Science, 2007 PubMed Europe PMC Scholia
  112. Yuin-Han Loh, Qiang Wu, Joon-Lin Chew, Vinsensius B Vega, Weiwei Zhang, Xi Chen, Guillaume Bourque, Joshy George, Bernard Leong, Jun Liu, Kee-Yew Wong, Ken W Sung, Charlie W H Lee, Xiao-Dong Zhao, Kuo-Ping Chiu, Leonard Lipovich, Vladimir A Kuznetsov, Paul Robson, Lawrence W Stanton, Chia-Lin Wei, Yijun Ruan, Bing Lim and Huck-Hui Ng; ''The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells''; Nature Genetics 38, 431 - 44, 2006 PubMed Europe PMC Scholia
  113. Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, Blakely K, Smiley S, Marcon E, Roudeva D, Li J, Olsen JB, Punna T, Isserlin R, Chetyrkin S, Gingras AC, Emili A, Greenblatt J, Moffat J; ''A lentiviral-based functional proteomics approach identifies chromatin remodelling complexes important for the induction of pluripotency''; Mol Cell Proteomics, 2010 PubMed Europe PMC Scholia
  114. Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, Thomson JA, Zwaka TP; ''Caspase activity mediates the differentiation of embryonic stem cells''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  115. Hao J, Li TG, Qi X, Zhao DF, Zhao GQ; ''WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells''; Dev Biol, 2006 PubMed Europe PMC Scholia
  116. Lee J, Rhee BK, Bae GY, Han YM, Kim J; ''Stimulation of Oct-4 activity by Ewing's sarcoma protein''; Stem Cells, 2005 PubMed Europe PMC Scholia
  117. Chen X, Fang F, Liou YC, Ng HH; ''Zfp143 regulates Nanog through modulation of Oct4 binding''; Stem Cells, 2008 PubMed Europe PMC Scholia
  118. Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH; ''The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia
  119. Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C; ''The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  120. Parisi S, Cozzuto L, Tarantino C, Passaro F, Ciriello S, Aloia L, Antonini D, De Simone V, Pastore L, Russo T; ''Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state''; BMC Biol, 2010 PubMed Europe PMC Scholia
  121. Cartwright P, McLean C, Sheppard A, Rivett D, Jones K, Dalton S; ''LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism''; Development, 2005 PubMed Europe PMC Scholia
  122. Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, Jing NH, Chen T, Li E, Sasaki H, Xu GL; ''Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog''; Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  123. Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A; ''PIAS Proteins as Repressors of Oct4 Function''; J Mol Biol, 2007 PubMed Europe PMC Scholia
  124. Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T, Nishiyama A, Koide H, Ko MS, Niwa H, Yokota T; ''Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  125. Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A; ''Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays''; J Cell Physiol, 2008 PubMed Europe PMC Scholia
  126. Sampath P, Pritchard DK, Pabon L, Reinecke H, Schwartz SM, Morris DR, Murry CE; ''A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  127. Liao B, Jin Y; ''Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner''; Cell Res, 2010 PubMed Europe PMC Scholia
  128. Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''Esrrb Activates Oct4 Transcription and Sustains Self-renewal and Pluripotency in Embryonic Stem Cells''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  129. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y; ''Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells''; Stem Cells, 2009 PubMed Europe PMC Scholia
  130. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, Daley GQ; ''Cross-regulation of the Nanog and Cdx2 promoters''; Cell Res, 2009 PubMed Europe PMC Scholia
  131. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG; ''Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination''; Genome Res, 2010 PubMed Europe PMC Scholia
  132. Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, Tibboel D, Görlich D, Poot RA, Rottier RJ; ''Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors''; J Cell Biol, 2009 PubMed Europe PMC Scholia
  133. Kelly VR, Hammer GD; ''LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells''; Mol Cell Endocrinol, 2010 PubMed Europe PMC Scholia
  134. Fazzio TG, Huff JT, Panning B; ''An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity''; Cell, 2008 PubMed Europe PMC Scholia
  135. Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D; ''Jarid2 and PRC2, partners in regulating gene expression''; Genes Dev, 2010 PubMed Europe PMC Scholia
  136. Chen L, Khillan JS; ''A novel signaling by vitamin A/retinol promotes self renewal of mouse embryonic stem cells by activating PI3K/Akt signaling pathway via insulin-like growth factor-1 receptor''; Stem Cells, 2010 PubMed Europe PMC Scholia
  137. Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC; ''Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  138. Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y; ''Krüppel-like factor 5 Is Essential for Blastocyst Development and the Normal Self-Renewal of Mouse ESCs''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  139. Wu DY, Yao Z; ''Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter''; Cell Res, 2006 PubMed Europe PMC Scholia
  140. Kosaka N, Sakamoto H, Terada M, Ochiya T; ''Pleiotropic Function of FGF-4: Its Role in Development and setm cells''; Dev Dyn, 2009 PubMed Europe PMC Scholia
  141. Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F; ''Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells''; J Mol Chem, 2005 PubMed Europe PMC Scholia
  142. Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, Russo T; ''Klf5 is involved in self-renewal of mouse embryonic stem cells''; J Cell Sci, 2008 PubMed Europe PMC Scholia
  143. Sapkota G, Alarcón C, Spagnoli FM, Brivanlou AH, Massagué J; ''Balancing BMP signaling through integrated inputs into the Smad1 linker''; Mol Cell, 2007 PubMed Europe PMC Scholia
  144. Fuhrmann G, Chung A, Jackson K, Hummelke G, Baniahmad A, Sutter J, Sylvester I, Schöler H, Cooney A; ''Mouse germline restriction of Oct4 expression by germ cell nuclear factor''; Dev Cell, 2001 PubMed Europe PMC Scholia
  145. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  146. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT; ''Cdk2ap1 Is Required for Epigenetic Silencing of Oct4 during Murine Embryonic Stem Cell Differentiation''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  147. Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B; ''T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways''; Stem Cells, 2008 PubMed Europe PMC Scholia
  148. Adams IR, McLaren A; ''Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells''; Dev Dyn, 2004 PubMed Europe PMC Scholia
  149. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J; ''Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation''; Cell, 2005 PubMed Europe PMC Scholia
  150. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH; ''Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells''; Cell, 2008 PubMed Europe PMC Scholia
  151. Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, Shiota K, Sugino H, Asashima M; ''TIF1{beta} regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  152. Yeap LS, Hayashi K, Surani MA; ''ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage''; Epigenetics Chromatin, 2009 PubMed Europe PMC Scholia
  153. Lee J, Go Y, Kang I, Han YM, Kim J; ''Oct-4 controls cell cycle progression of embryonic stem cells''; Biochem J, 2010 PubMed Europe PMC Scholia
  154. Ko SY, Kang HY, Lee HS, Han SY, Hong SH; ''Identification of Jmjd1a as a STAT3 downstream gene in mES cells''; Cell Struct Funct, 2006 PubMed Europe PMC Scholia
  155. Bard JD, Gelebart P, Amin HM, Young LC, Ma Y, Lai R; ''Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4''; FASEB J, 2009 PubMed Europe PMC Scholia
  156. Zhu D, Fang J, Li Y, Zhang J; ''Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation''; PLoS One, 2009 PubMed Europe PMC Scholia
  157. Yang J, Gao C, Chai L, Ma Y; ''A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells''; PLoS One, 2010 PubMed Europe PMC Scholia
  158. Campbell PA, Perez-Iratxeta C, Andrade-Navarro MA, Rudnicki MA; ''Oct4 Targets Regulatory Nodes to Modulate Stem Cell Function''; PLoS One, 2007 PubMed Europe PMC Scholia
  159. Addis RC, Prasad M, Yochem RL, Zhan X, Sheets T, Axelman J, Patterson ES, Shamblott MJ; ''OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells''; J Cell Biochem, 2010 PubMed Europe PMC Scholia
  160. Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, Kittler R, Junqueira M, Shevchenko A, Schulz H, Hubner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F; ''A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity''; Cell Stem Cell, 2009 PubMed Europe PMC Scholia
  161. Sekkaï D, Gruel G, Herry M, Moucadel V, Constantinescu SN, Albagli O, Tronik-Le Roux D, Vainchenker W, Bennaceur-Griscelli A; ''Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells''; Stem Cells, 2005 PubMed Europe PMC Scholia
  162. Paling NR, Wheadon H, Bone HK, Welham MJ; ''Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  163. Hong F, Fang F, He X, Cao X, Chipperfield H, Xie D, Wong WH, Ng HH, Zhong S; ''Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells''; PLoS Comput Biol, 2009 PubMed Europe PMC Scholia
  164. Niwa H, Burdon T, Chambers I, Smith A; ''Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3''; Genes Dev, 1998 PubMed Europe PMC Scholia
  165. Sun Y, Li H, Yang H, Rao MS, Zhan M; ''Mechanisms Controlling Embryonic Stem Cell Self-Renewal and Differentiation''; Critical Reviews in Eukaryotic Gene Expression, 2006 PubMed Europe PMC Scholia
  166. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA; ''Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells''; Cell, 2005 PubMed Europe PMC Scholia
  167. Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH; ''Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells''; Genes Dev, 2009 PubMed Europe PMC Scholia
  168. Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL; ''Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia
  169. Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, Ward DC, Ma Y; ''Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  170. Katoh M, Katoh M; ''WNT Signaling Pathway and Stem Cell Signaling Network''; Clin Cancer Res, 2007 PubMed Europe PMC Scholia
  171. Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH; ''Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  172. Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA; ''Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells''; Genes Dev, 2008 PubMed Europe PMC Scholia
  173. Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J; ''Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling''; Mol Cell, 2009 PubMed Europe PMC Scholia
  174. Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM, Zernicka-Goetz M; ''CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation''; Stem Cells, 2009 PubMed Europe PMC Scholia
  175. Takao Y, Yokota T, Koide H; ''Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  176. Torres J, Watt FM; ''Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3''; Nat Cell Biol, 2008 PubMed Europe PMC Scholia
  177. Niwa H; ''How is pluripotency determined and maintained?''; Development, 2007 PubMed Europe PMC Scholia
  178. Park S, Hu X, Gupta P, Lin Y, Ha S, Wei L; ''SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells''; Nature Structural & Molecular Biology, 2007 PubMed Europe PMC Scholia
  179. Loh YH, Zhang W, Chen X, George J, Ng HH; ''Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells''; Genes Dev, 2007 PubMed Europe PMC Scholia
  180. Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, Lim SL, Cao S, Tay J, Orlov YL, Lufkin T, Ng HH, Tam WL, Lim B; ''Tbx3 improves the germ-line competency of induced pluripotent stem cells''; Nature, 2010 PubMed Europe PMC Scholia
  181. Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C; ''Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  182. Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y; ''G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  183. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism''; Nature, 2001 PubMed Europe PMC Scholia
  184. Zhang Z, Liao B, Xu M, Jin Y; ''Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1''; FASEB J, 2007 PubMed Europe PMC Scholia
  185. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, Reizis B; ''Zfx controls the self-renewal of embryonic and hematopoietic stem cells''; Cell, 2007 PubMed Europe PMC Scholia
  186. Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D; ''Regulation of the pluripotency marker Rex-1 by Nanog and Sox2''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  187. van den Berg DL, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, Demmers J, Chambers I, Poot RA; ''Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  188. Satou A, Taira T, Iguchi-Ariga SM, Ariga H; ''A novel transrepression pathway of c-Myc''; Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein, 2001 PubMed Europe PMC Scholia
  189. Takahashi K, Mitsui K, Yamanaka S; ''Role of ERas in promoting tumour-like properties in mouse embryonic stem cells''; Nature, 2003 PubMed Europe PMC Scholia
  190. Pan G, Li J, Zhou Y, Zheng H, Pei D; ''A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal''; FASEB J, 2006 PubMed Europe PMC Scholia
  191. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC; ''Trim24 targets endogenous p53 for degradation''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  192. Vallania F, Schiavone D, Dewilde S, Pupo E, Garbay S, Calogero R, Pontoglio M, Provero P, Poli V; ''Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  193. Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R; ''Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression''; Genes Dev, 2009 PubMed Europe PMC Scholia
  194. Lee JL, Wang MJ, Chen JY; ''Acetylation and activation of STAT3 mediated by nuclear translocation of CD44''; J Cell Biol, 2009 PubMed Europe PMC Scholia
  195. Okita K, Yamanaka S; ''Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells''; Curr Stem Cell Res Ther, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126404view19:29, 26 April 2023EgonwLicense is CCZero
120787view11:44, 6 January 2022EweitzModified title
113634view20:41, 8 November 2020EveloModified title
89515view10:58, 16 September 2016Mkutmonpubref/ontology tag fix
89475view13:39, 15 September 2016Mkutmonremove space from ontology term id
72003view11:53, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
69951view20:43, 11 July 2013MaintBotupdating to 2013 schema
67598view11:31, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development ' added !
41345view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
40000view20:36, 22 January 2011AlexanderPicoModified categories
39726view21:54, 14 January 2011AlexanderPicoOntology Term : 'pluripotent stem cell' added !
39722view12:24, 14 January 2011C.HarderModified description
39721view12:21, 14 January 2011C.Harderwe connected the lines to the nodes
39719view12:07, 14 January 2011C.HarderDeleted pathway: updated version
39647view13:08, 6 January 2011C.HarderModified categories
39547view14:00, 18 December 2010C.HarderModified description
39546view13:55, 18 December 2010C.HarderModified description
39545view13:48, 18 December 2010C.HarderNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1600029D21Rik76509 (Entrez Gene) full name: RIKEN cDNA 1600029D21 gene
Acvr111477 (Entrez Gene) full name: activin A receptor, type 1
Acvr1b11479 (Entrez Gene) full name: activin A receptor, type 1B / Alk4
Acvr1c269275 (Entrez Gene) full name: activin A receptor, type IC / Alk7
Aes14797 (Entrez Gene) full name: amino-terminal enhancer of split
Akt111651 (Entrez Gene) full name: thymoma viral proto-oncogene 1
Apc11789 (Entrez Gene) full name: adenomatosis polyposis coli
Arid3b56380 (Entrez Gene) full name: AT rich interactive domain 3B (BRIGHT-like)
Atf211909 (Entrez Gene) full name: activating transcription factor 2
Atrx22589 (Entrez Gene) full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human)
Axin112005 (Entrez Gene) full name: Axin1
Bcam57278 (Entrez Gene) full name: basal cell adhesion molecule
Bmp412159 (Entrez Gene) full name: bone morphogenetic protein 4
Bmpr212168 (Entrez Gene) full name: bone morphogenic protein receptor, type II (serine/threonine kinase)
Brca112189 (Entrez Gene) full name: breast cancer 1
Cabin1104248 (Entrez Gene) full name: calcineurin binding protein 1
Cad69719 (Entrez Gene) full name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Carm174766 (Entrez Gene) full name: coactivator-associated arginine methyltransferase 1
Casp312367 (Entrez Gene) full name: caspase 3
Ccnd112443 (Entrez Gene) full name: cyclin D1
Cd4412505 (Entrez Gene) full name: CD44 antigen
Cdc73214498 (Entrez Gene) full name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
Cdh112550 (Entrez Gene) full name: cadherin 1
Cdk212566 (Entrez Gene) full name: cyclin-dependent kinase 2
Cdk2ap113445 (Entrez Gene) full name: CDK2 (cyclin-dependent kinase 2)-associated protein 1
Cdkn1a12575 (Entrez Gene) full name: cyclin-dependent kinase inhibitor 1A (P21)
Cdkn2a12578 (Entrez Gene) full name: cyclin-dependent kinase inhibitor 2A
Cdx212591 (Entrez Gene) full name: caudal type homeo box 2
Cer112622 (Entrez Gene) full name: cerberus 1 homolog (Xenopus laevis)
Chd4107932 (Entrez Gene) full name: chromodomain helicase DNA binding protein 4
Creb112912 (Entrez Gene) full name: cAMP responsive element binding protein 1
Crebbp12914 (Entrez Gene) full name: CREB binding protein
Ctbp113016 (Entrez Gene) full name: C-terminal binding protein 1
Ctbp213017 (Entrez Gene) full name: C-terminal binding protein 2
Ctcf13018 (Entrez Gene) full name: CCCTC-binding factor
Ctnnb112387 (Entrez Gene) full name: catenin (cadherin associated protein), beta 1
Ctr922083 (Entrez Gene) full name: Ctr9 (Alco called "SH2 domain-binding protein 1")
Cubn65969 (Entrez Gene) full name: cubilin (intrinsic factor-cobalamin receptor)
Dazl13164 (Entrez Gene) full name: deleted in azoospermia-like
Ddb113194 (Entrez Gene) full name: damage specific DNA binding protein 1
Dffa13347 (Entrez Gene) full name: DNA fragmentation factor, alpha subunit
Dgka13139 (Entrez Gene) full name: diacylglycerol kinase, alpha
Dhx913211 (Entrez Gene) full name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Dkk113380 (Entrez Gene) full name: dickkopf homolog 1 (Xenopus laevis)
Dnmt113433 (Entrez Gene) full name: DNA methyltransferase (cytosine-5) 1
Dnmt3a13435 (Entrez Gene) full name: DNA methyltransferase 3A
Dnmt3b13436 (Entrez Gene) full name: DNA methyltransferase 3B
Dnmt3l54427 (Entrez Gene) full name: DNA (cytosine-5-)-methyltransferase 3-like
Dppa473693 (Entrez Gene) full name: developmental pluripotency associated 4
Dpysl212934 (Entrez Gene) full name: dihydropyrimidinase-like 2
Dvl113542 (Entrez Gene) full name: dishevelled, dsh homolog 1 (Drosophila)
E130012A19Rik103551 (Entrez Gene) full name: RIKEN cDNA E130012A19 gene
Eed13626 (Entrez Gene) full name: embryonic ectoderm development
Ehmt177683 (Entrez Gene) full name: euchromatic histone methyltransferase 1
Ehmt2110147 (Entrez Gene) full name: euchromatic histone lysine N-methyltransferase 2
Ep300328572 (Entrez Gene) full name: E1A binding protein p300
Ep40075560 (Entrez Gene) full name: E1A binding protein p400
Eras353283 (Entrez Gene) full name: ES cell-expressed Ras
Ercc522592 (Entrez Gene) full name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Esrrb26380 (Entrez Gene) full name: estrogen related receptor, beta
Etv5104156 (Entrez Gene) full name: ets variant gene 5
Ewsr114030 (Entrez Gene) full name: Ewing sarcoma breakpoint region 1
Ezh114055 (Entrez Gene) full name: enhancer of zeste homolog 1 (Drosophila)
Ezh214056 (Entrez Gene) full name: enhancer of zeste homolog 2 (Drosophila)
Fam129a63913 (Entrez Gene) full name: family with sequence similarity 129, member A
Fbxo1550764 (Entrez Gene) full name: F-box protein 15
Fgf414175 (Entrez Gene) full name: fibroblast growth factor 4
Fgf514176 (Entrez Gene) full name: fibroblast growth factor 5
Fgfr114182 (Entrez Gene) full name: fibroblast growth factor receptor 1
Fos14281 (Entrez Gene) full name: FBJ osteosarcoma oncogene
Foxd315221 (Entrez Gene) full name: forkhead box D3
Frap156717 (Entrez Gene) full name: FK506 binding protein 12-rapamycin associated protein 1
Fzd114362 (Entrez Gene) full name: frizzled homolog 1 (Drosophila)
Gab114388 (Entrez Gene) full name: growth factor receptor bound protein 2-associated protein 1
Gadd45a13197 (Entrez Gene) full name: growth arrest and DNA-damage-inducible 45 alpha
Gadd45gip1102060 (Entrez Gene) full name: growth arrest and DNA-damage-inducible, gamma interacting protein 1
Gata614465 (Entrez Gene) full name: GATA binding protein 6
Gatad2a234366 (Entrez Gene) full name: GATA zinc finger domain containing 2A
Gatad2b229542 (Entrez Gene) full name: GATA zinc finger domain containing 2B
Gbx214472 (Entrez Gene) full name: gastrulation brain homeobox 2
Gdf914566 (Entrez Gene) full name: growth differentiation factor 9
Grb214784 (Entrez Gene) full name: growthfactorreceptor-boundprotein2
Grsf1231413 (Entrez Gene) full name: G-rich RNA sequence binding factor 1
Gsk3b56637 (Entrez Gene) full name: glycogen synthase kinase 3 beta
H3f3a15078 (Entrez Gene) full name: H3 histone, family 3A
Hand215111 (Entrez Gene) full name: heart and neural crest derivatives expressed transcript 2
Hcfc115161 (Entrez Gene) full name: host cell factor C1
Hck15162 (Entrez Gene) full name: hemopoietic cell kinase
Hdac1433759 (Entrez Gene) full name: histone deacetylase 1
Hdac215182 (Entrez Gene) full name: Histone deacetylase 2
Hdac4208727 (Entrez Gene) full name: histone deacetylase 4
Hells15201 (Entrez Gene) full name: helicase, lymphoid specific
Hif1a15251 (Entrez Gene) full name: hypoxia inducible factor 1, alpha subunit
Hira15260 (Entrez Gene) full name: histone cell cycle regulation defective homolog A (S. cerevisiae)
Hnrnpu51810 (Entrez Gene) full name: heterogeneous nuclear ribonucleoprotein U
Hras115461 (Entrez Gene) full name: Harvey rat sarcoma virus oncogene 1
Icam115894 (Entrez Gene) full name: intercellular adhesion molecule 1
Id115901 (Entrez Gene) full name: inhibitor of DNA binding 1
Igfbp316009 (Entrez Gene) full name: insulin-like growth factor binding protein 3
Il6st16195 (Entrez Gene) full name: interleukin 6 signal transducer
Inhbb16324 (Entrez Gene) full name: inhibin beta-B
Ins116333 (Entrez Gene) full name: insulin I
Insr16337 (Entrez Gene) full name: insulin receptor
Ipo7233726 (Entrez Gene) full name: importin 7
Ipo9226432 (Entrez Gene) full name: importin 9
Irs116367 (Entrez Gene) full name: insulin receptor substrate 1
Itgb116412 (Entrez Gene) full name: integrin beta 1 (fibronectin receptor beta)
Jak116451 (Entrez Gene) full name: Janus kinase 1
Jarid216468 (Entrez Gene) full name: jumonji, AT rich interactive domain 2
Kat581601 (Entrez Gene) full name: K(lysine) acetyltransferase 5
Kdm1a99982 (Entrez Gene) full name: lysine (K)-specific demethylase 1A
Kdm3a104263 (Entrez Gene) full name: lysine (K)-specific demethylase 3A
Kdm4c76804 (Entrez Gene) full name: lysine (K)-specific demethylase 4C
Kdm5c20591 (Entrez Gene) full name: lysine (K)-specific demethylase 5C
Kdm6a22289 (Entrez Gene) full name: 4lysine (K)-specific demethylase 6A
Kdm6b216850 (Entrez Gene) full name: KDM1 lysine (K)-specific demethylase 6B
Klf216598 (Entrez Gene) full name: Kruppel-like factor 2 (lung)
Klf416600 (Entrez Gene) full name: Kruppel-like factor 4 (gut)
Klf512224 (Entrez Gene) full name: Kruppel-like factor 5
Kpna216647 (Entrez Gene) full name: karyopherin (importin) alpha 2
Kpnb116211 (Entrez Gene) full name: karyopherin (importin) beta 1
Lef116842 (Entrez Gene) full name: lymphoid enhancer binding factor 1
Lefty113590 (Entrez Gene) full name: left right determination factor 1
Leo1235497 (Entrez Gene) full name: Leo1
Lif16878 (Entrez Gene) full name: leukemia inhibitory factor
Lifr16880 (Entrez Gene) full name: leukemia inhibitory factor receptor
Lrp516973 (Entrez Gene) full name: low density lipoprotein receptor-related protein 5
Lyar17089 (Entrez Gene) full name: Ly1 antibody reactive clone
Map2k126395 (Entrez Gene) full name: mitogen-activated protein kinase kinase 1
Mapk126413 (Entrez Gene) full name: mitogen-activated protein kinase 1
Mapk326417 (Entrez Gene) full name: mitogen-activated protein kinase 3
Mbd217191 (Entrez Gene) full name: methyl-CpG binding domain protein 2
Mbd317192 (Entrez Gene) full name: methyl-CpG binding domain protein 3
Mdm217246 (Entrez Gene) full name: transformed mouse 3T3 cell double minute 2
Med1259024 (Entrez Gene) full name: mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
Mef2c17260 (Entrez Gene) full name: myocyte enhancer factor 2C
Mef2d17261 (Entrez Gene) full name: myocyte enhancer factor 2D
Mitf17342 (Entrez Gene) full name: microphthalmia-associated transcription factor
Mll2381022 (Entrez Gene) full name: myeloid/lymphoid or mixed-lineage leukemia 2, ALR
Mpl17480 (Entrez Gene) full name: myeloproliferative leukemia virus oncogene
Mta1116870 (Entrez Gene) full name: metastasis associated 1
Mta223942 (Entrez Gene) full name: metastasis-associated gene family, member 2
Mtf217765 (Entrez Gene) full name: metal response element binding transcription factor 2 / PCL2
Mybl217865 (Entrez Gene) full name: myeloblastosis oncogene-like 2
Myc17869 (Entrez Gene) full name: myelocytomatosis oncogene
Mycn18109 (Entrez Gene) full name: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Myod117927 (Entrez Gene) full name: myogenic differentiation 1
Nacc166830 (Entrez Gene) full name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Nanog71950 (Entrez Gene) full name: Nanog homeobox
Ncl17975 (Entrez Gene) full name: nucleolin
Ncoa117977 (Entrez Gene) full name: nuclear receptor coactivator 1
Nedd4l83814 (Entrez Gene) full name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Nfkb118033 (Entrez Gene) full name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Nkd193960 (Entrez Gene) full name: naked cuticle 1 homolog (Drosophila)
Nme218103 (Entrez Gene) full name: non-metastatic cells 2, protein (NM23B) expressed in
Nobox18291 (Entrez Gene) full name: NOBOX oogenesis homeobox
Nodal18119 (Entrez Gene) full name: Nodal homolog
Notch118128 (Entrez Gene) full name: Notch gene homolog 1 (Drosophila)
Nppb18158 (Entrez Gene) full name: natriuretic peptide precursor type B
Npr118160 (Entrez Gene) full name: natriuretic peptide receptor 1
Nr0b111614 (Entrez Gene) full name: nuclear receptor subfamily 0, group B, member 1
Nr2c122025 (Entrez Gene) full name: nuclear receptor subfamily 2, group C, member 1
Nr2f113865 (Entrez Gene) full name: nuclear receptor subfamily 2, group F, member 1
Nr2f211819 (Entrez Gene) full name: nuclear receptor subfamily 2, group F, member 2
Nr2f613864 (Entrez Gene) full name: nuclear receptor subfamily 2, group F, member 6
Nr5a226424 (Entrez Gene) full name: nuclear receptor subfamily 5, group A, member 2
Nr6a1328572 (Entrez Gene) full name: nuclear receptor subfamily 6, group A, member 1
Ocln18260 (Entrez Gene) full name: occludin
Ogt108155 (Entrez Gene) full name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Otx218424 (Entrez Gene) full name: orthodenticle homolog 2 (Drosophila)
P4ha118451 (Entrez Gene) full name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Paf154624 (Entrez Gene) full name: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Parp111545 (Entrez Gene) full name: poly (ADP-ribose) polymerase family, member 1
Pax677766 (Entrez Gene) full name: paired box gene 6
Pbrm166923 (Entrez Gene) full name: polybromo 1 / BAF180
Perp64058 (Entrez Gene) full name: PERP, TP53 apoptosis effector
Phc113619 (Entrez Gene) full name: polyhomeotic-like 1 (Drosophila)
Phf17269424 (Entrez Gene) full name: PHD finger protein 17
Pias217344 (Entrez Gene) full name: protein inhibitor of activated STAT 2
Pias459004 (Entrez Gene) full name: protein inhibitor of activated STAT 4; PIASy
Pik3cd18707 (Entrez Gene) full name: phosphatidylinositol 3-kinase, catalytic delta polypeptide
Pim118712 (Entrez Gene) full name: proviral integration site 1
Pim3223775 (Entrez Gene) full name: proviral integration site 3
Pin123988 (Entrez Gene) full name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Pml18854 (Entrez Gene) full name: promyelocytic leukemia
Pou2f118986 (Entrez Gene) full name: POU domain, class 2, transcription factor 1
Pou5f118999 (Entrez Gene) full name: POU domain, class 5, transcription factor 1
Ppp2r1a51792 (Entrez Gene) full name: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
Prkaca18747 (Entrez Gene) full name: protein kinase, cAMP dependent, catalytic, alpha
Prkcc18752 (Entrez Gene) full name: protein kinase C, gamma
Psen119164 (Entrez Gene) full name: Presenilin 1
Pten19211 (Entrez Gene) full name: phosphatase and tensin homolog
Ptpn1119247 (Entrez Gene) full name: protein tyrosine phosphatase, non-receptor type 11
Ptprs19280 (Entrez Gene) full name: protein tyrosine phosphatase, receptor type, S
Raf1110157 (Entrez Gene) full name: v-raf-leukemia viral oncogene 1
Rbbp419646 (Entrez Gene) full name: retinoblastoma binding protein 4
Rbbp7245688 (Entrez Gene) full name: retinoblastoma binding protein 7
Rbl219651 (Entrez Gene) full name: retinoblastoma-like 2
Rbpj19664 (Entrez Gene) full name: recombination signal binding protein for immunoglobulin kappa J region
Rcn226611 (Entrez Gene) full name: reticulocalbin 2
Rcor2104383 (Entrez Gene) full name: REST corepressor 2
Rel19696 (Entrez Gene) full name: reticuloendotheliosis oncogene
Rela19697 (Entrez Gene) full name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Relb19698 (Entrez Gene) full name: avian reticuloendotheliosis viral (v-rel) oncogene related B
Rest19712 (Entrez Gene) full name: RE1-silencing transcription factor
Rif151869 (Entrez Gene) full name: Rap1 interacting factor 1 homolog (yeast)
Rnf219821 (Entrez Gene) full name: ring finger protein 2
Rock119877 (Entrez Gene) full name: Rho-associated coiled-coil containing protein kinase 1
Rock219878 (Entrez Gene) full name: Rho-associated coiled-coil containing protein kinase 2
Rras20130 (Entrez Gene) full name: Harvey rat sarcoma oncogene, subgroup R
Rtn4r65079 (Entrez Gene) full name: reticulon 4 receptor
Rybp56353 (Entrez Gene) full name: RING1 and YY1 binding protein
Sall158198 (Entrez Gene) full name: sal-like 1 (Drosophila)
Sall320689 (Entrez Gene) full name: sal-like 3 (Drosophila)
Sall499377 (Entrez Gene) full name: sal-like 4 (Drosophila)
Satb120230 (Entrez Gene) full name: special AT-rich sequence binding protein 1
Satb2212712 (Entrez Gene) full name: special AT-rich sequence binding protein 2
Setdb176893 (Entrez Gene) full name: SET domain, bifurcated 1
Sf122668 (Entrez Gene) full name: splicing factor 1
Sgk120393 (Entrez Gene) full name: serum/glucocorticoid regulated kinase 1
Shh20423 (Entrez Gene) full name: sonic hedgehog
Sin3a20466 (Entrez Gene) full name: transcriptional regulator, SIN3A (yeast)
Smad117125 (Entrez Gene) full name: MAD homolog 1 (Drosophila)
Smad217126 (Entrez Gene) full name: MAD homolog 2 (Drosophila)
Smad317127 (Entrez Gene) full name: MAD homolog 3 (Drosophila)
Smad417128 (Entrez Gene) full name: MAD homolog 4 (Drosophila)
Smad717131 (Entrez Gene) full name: MADhomolog7
Smarca267155 (Entrez Gene) full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Smarca420586 (Entrez Gene) full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Smarca593762 (Entrez Gene) full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Smarcad113990 (Entrez Gene) full name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Smarcc120588 (Entrez Gene) full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Smo319757 (Entrez Gene) full name: smoothened homolog (Drosophila)
Smurf175788 (Entrez Gene) full name: SMAD specific E3 ubiquitin protein ligase 1
Socs1216233 (Entrez Gene) full name: suppressorofcytokinesignaling2
Sos120662 (Entrez Gene) full name: Son of sevenless homolog 1 (Drosophila)
Sox220674 (Entrez Gene) full name: SRY-box containing gene 2
Sp120683 (Entrez Gene) full name: trans-acting transcription factor 1
Sp320687 (Entrez Gene) full name: trans-acting transcription factor 3
Spp120750 (Entrez Gene) full name: secreted phosphoprotein 1
Ssrp120833 (Entrez Gene) full name: structure specific recognition protein 1
Stat320848 (Entrez Gene) full name: signal transducer and activator of transcription 3
Stk4074178 (Entrez Gene) full name: serine/threonine kinase 40
Sumo122218 (Entrez Gene) full name: SMT3 suppressor of mif two 3 homolog 1 (yeast)
Suz1252615 (Entrez Gene) full name: suppressor of zeste 12 homolog (Drosophila)
T20997 (Entrez Gene) full name: brachyury
Tbx321386 (Entrez Gene) full name: T-box3
Tcf321415 (Entrez Gene) full name: transcription factor 3
Tcf721414 (Entrez Gene) full name: Transcription factor7 ,T-cell specific
Tcfap2a21418 (Entrez Gene) full name: transcription factor AP-2, alpha
Tcfap2c21420 (Entrez Gene) full name: transcription factor AP-2, gamma
Tcfcp2l181879 (Entrez Gene) full name: transcription factor CP2-like 1
Tcfe3209446 (Entrez Gene) full name: transcription factor E3
Tcfeb21425 (Entrez Gene) full name: transcription factor EB
Tcl121432 (Entrez Gene) full name: T-cell lymphoma breakpoint 1
Terf221750 (Entrez Gene) full name: telomeric repeat binding factor 2
Tert21752 (Entrez Gene) full name: telomerase reverse transcriptase
Tet152463 (Entrez Gene) full name: tet oncogene 1
Tgfb121803 (Entrez Gene) full name: transforming growth factor, beta 1
Tgfbr121812 (Entrez Gene) full name: transforming growth factor, beta receptor I / ALK5
Thap1159016 (Entrez Gene) full name: THAP domain containing 11
Tle221886 (Entrez Gene) full name: transducin-like enhancer of split 2, homolog of Drosophila E(spl)
Tle421888 (Entrez Gene) full name: Transducin-likeenhancerofsplit4
Tpo22018 (Entrez Gene) full name: thyroid peroxidase
Trim2421848 (Entrez Gene) full name: tripartite motif-containing 24
Trim2821849 (Entrez Gene) full name: Tripartitemotif-containing28
Trim3394093 (Entrez Gene) full name: tripartite motif-containing 33
Trp5322059 (Entrez Gene) full name: transformation related protein 53
Tsix22097 (Entrez Gene) full name: X (inactive)-specific transcript, antisense
Twist122160 (Entrez Gene) full name: twist gene homolog 1 (Drosophila)
Ube2i22196 (Entrez Gene) full name: ubiquitin-conjugating enzyme E2I
Uhrf118140 (Entrez Gene) full name: ubiquitin-like, containing PHD and RING finger domains, 1
Usp7252870 (Entrez Gene) full name: ubiquitin specific peptidase 7
Utf122286 (Entrez Gene) full name: undifferentiated embryonic cell transcription factor 1
Wdr6166317 (Entrez Gene) full name: WD repeat domain 61
Wnt3a22416 (Entrez Gene) full name: wingless-related MMTV integration site 3A
Wnt5a22418 (Entrez Gene) full name: wingless-related MMTV integration site 5A
Wwp266894 (Entrez Gene) full name: WW domain containing E3 ubiquitin protein ligase 2
Xist213742 (Entrez Gene) full name: inactive X specific transcripts
Xite619209 (Entrez Gene) full name: X-inactivation intergenic transcription element
Xpo457258 (Entrez Gene) full name: exportin 4
Yy122632 (Entrez Gene) full name: YY1 transcription factor
Zfp14320841 (Entrez Gene) full name: zinc finger protein 143
Zfp21969890 (Entrez Gene) full name: zinc finger protein 219
Zfp281226442 (Entrez Gene) full name: zinc finger protein 281
Zfp4222702 (Entrez Gene) full name: zinc finger protein 42
Zfp5722715 (Entrez Gene) full name: zinc finger protein 57
Zfx22764 (Entrez Gene) full name: zinc finger protein X-linked
Zic222772 (Entrez Gene) full name: zinc finger protein of the cerebellum 2
Zic322773 (Entrez Gene) full name: zinc finger protein of the cerebellum 3
Zmym276007 (Entrez Gene) full name: zinc finger, MYM-type 2
Zscan10332221 (Entrez Gene) full name: zinc finger and SCAN domain containing 10

Annotated Interactions

No annotated interactions

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